Uterine epithelial cell proliferation and endometrial hyperplasia: evidence from a mouse model [0.03%]
子宫内膜增生的细胞学机制及动物模型研究进展
Yang Gao,Shu Li,Qinglei Li
Yang Gao
In the uterus, epithelial cell proliferation changes during the estrous cycle and pregnancy. Uncontrolled epithelial cell proliferation results in implantation failure and/or cancer development. Transforming growth factor-β (TGF-β) signal...
Characterization of the human cumulus cell transcriptome during final follicular maturation and ovulation [0.03%]
人类卵泡最终成熟和排卵期间黄体细胞转录组的特征分析
G M Yerushalmi,M Salmon-Divon,Y Yung et al.
G M Yerushalmi et al.
Cumulus expansion and oocyte maturation are central processes in ovulation. Knowledge gained from rodent and other mammalian models has revealed some of the molecular pathways associated with these processes. However, the equivalent pathway...
Validation of endogenous normalizing genes for expression analyses in adult human testis and germ cell neoplasms [0.03%]
验证睾丸和生殖细胞肿瘤中内源性归一化基因的表达分析
T Svingen,A Jørgensen,E Rajpert-De Meyts
T Svingen
The measurement of gene expression levels in cells and tissues typically depends on a suitable point of reference for inferring biological relevance. For quantitative (or real-time) RT-PCR assays, the method of choice is often to normalize ...
I López-González,P Torres-Rodríguez,O Sánchez-Carranza et al.
I López-González et al.
Sperm capacitation is a complex and indispensable physiological process that spermatozoa must undergo in order to acquire fertilization capability. Spermatozoa from several mammalian species, including mice, exhibit a capacitation-associate...
Single- and double-stranded viral RNA generate distinct cytokine and antiviral responses in human fetal membranes [0.03%]
单链和双链病毒RNA在人胎膜中产生不同的细胞因子和抗病毒反应
S L Bakaysa,J A Potter,M Hoang et al.
S L Bakaysa et al.
There has been growing interest in the role of viral infections and their association with adverse pregnancy outcomes. However, little is known about the impact viral infections have on the fetal membranes (FM). Toll-like receptors (TLR) ar...
C De Paepe,M Krivega,G Cauffman et al.
C De Paepe et al.
During human preimplantation development the totipotent zygote divides and undergoes a number of changes that lead to the first lineage differentiation in the blastocyst displaying trophectoderm (TE) and inner cell mass (ICM) on Day 5. The ...
J I Iruretagoyena,W Davis,C Bird et al.
J I Iruretagoyena et al.
The primitive cardiac tube starts beating 6-8 weeks post fertilization in the developing embryo. In order to describe normal cardiac development during late first and early second trimester in human fetuses this study used microarray and pa...
Potential role of endometrial stem/progenitor cells in the pathogenesis of early-onset endometriosis [0.03%]
子宫内膜干细胞/祖细胞在早期发病的子宫内膜异位症发病机制中的潜在作用
C E Gargett,K E Schwab,J J Brosens et al.
C E Gargett et al.
The pathogenesis of early-onset endometriosis has recently been revisited, sparked by the discovery of endometrial stem/progenitor cells and their possible role in endometriosis, and because maternal pregnancy hormone withdrawal following d...
Generation of human endometrial knockout cell lines with the CRISPR/Cas9 system confirms the prostaglandin F2α synthase activity of aldo-ketoreductase 1B1 [0.03%]
CRISPR/Cas9系统生成的人子宫内膜敲除细胞系确认了醛酮还原酶1B1的前列腺素F2α合酶活性
Nicolas Lacroix Pépin,Pierre Chapdelaine,Yoima Rodriguez et al.
Nicolas Lacroix Pépin et al.
Prostaglandins (PGs) are important regulators of female reproductive function. The primary PGs produced in the endometrium are PGE2 and PGF2α. Relatively little is known about the biosynthetic pathways leading to the formation of PGF2α. W...
Follicle-stimulating hormone receptor (FSHR) alternative skipping of exon 2 or 3 affects ovarian response to FSH [0.03%]
FSH受体（FSHR）外显子2或3的替代跳跃影响卵巢对FSH的反应
Cengiz Karakaya,Ozlem Guzeloglu-Kayisli,Rebecca J Hobbs et al.
Cengiz Karakaya et al.
Genes critical for fertility are highly conserved in mammals. Interspecies DNA sequence variation, resulting in amino acid substitutions and post-transcriptional modifications, including alternative splicing, are a result of evolution and s...