Developmental programming of obesity and insulin resistance: does mitochondrial dysfunction in oocytes play a role? [0.03%]
卵母细胞线粒体功能障碍在肥胖和胰岛素抵抗的表观遗传编程中起作用吗？
Nigel Turner,Rebecca L Robker
Nigel Turner
Insulin resistance is a key defect associated with obesity, type 2 diabetes and other metabolic diseases. While a number of factors have been suggested to cause defects in insulin action, there is a very strong association between inappropr...
CBP-CITED4 is required for luteinizing hormone-triggered target gene expression during ovulation [0.03%]
黄体生成素诱导的排卵过程中靶基因表达需要CBP-CITED4蛋白质复合物
Yin-Li Zhang,Yan Xia,Chao Yu et al.
Yin-Li Zhang et al.
Pituitary-secreted luteinizing hormone (LH) induces ovulation by activating an extracellular regulated kinase 1/2 (ERK1/2) cascade. However, little is known regarding the ERK1/2 downstream effectors that are involved in regulating rapid, tr...
A role for the mitochondrial-associated protein p32 in regulation of trophoblast proliferation [0.03%]
线粒体相关蛋白p32在滋养层细胞增殖调控中的作用
P Matos,J A Horn,F Beards et al.
P Matos et al.
p32 is a conserved eukaryotic protein which is primarily expressed in the mitochondria and regulates cell proliferation, migration and metabolism in various tissues. In this study, we sought to examine the expression and function of p32 in ...
Y Yung,S Aviel-Ronen,E Maman et al.
Y Yung et al.
The luteinizing hormone receptor (LHR) plays a pivotal role during follicular development. Consequently, its expression pattern is of major importance for research and has clinical implications. Despite the accumulated information regarding...
Comparative Study
Molecular human reproduction. 2014 Sep;20(9):844-9. DOI:10.1093/molehr/gau041 2014
Integrative transcriptome meta-analysis reveals widespread sex-biased gene expression at the human fetal-maternal interface [0.03%]
整合转录组元分析揭示了人类胎儿-母体界面广泛存在的性别偏向基因表达现象
Sam Buckberry,Tina Bianco-Miotto,Stephen J Bent et al.
Sam Buckberry et al.
As males and females share highly similar genomes, the regulation of many sexually dimorphic traits is constrained to occur through sex-biased gene regulation. There is strong evidence that human males and females differ in terms of growth ...
Notch-dependent RBPJκ inhibits proliferation of human cytotrophoblasts and their differentiation into extravillous trophoblasts [0.03%]
诺特信依赖的RBPJ kappa抑制人合体滋养细胞增殖及其向侵袭性滋养细胞分化
P Velicky,S Haider,G R Otti et al.
P Velicky et al.
Abnormal development of invasive trophoblasts has been implicated in the pathogenesis of human pregnancy diseases such as pre-eclampsia. However, critical signalling pathways controlling formation and differentiation of these cells have bee...
Dehydroascorbic acid taken up by glucose transporters stimulates estradiol production through inhibition of JNK/c-Jun/AP1 signaling in JAR cells [0.03%]
脱氢抗坏血酸通过抑制JNK/c-Jun/AP1信号通路刺激葡萄糖转运蛋白介导的雌二醇生成
Yongjie Wang,Chao Tang,Minglan Wu et al.
Yongjie Wang et al.
We have previously demonstrated that the reduced form of vitamin C (l-ascorbic acid, AA) is able to induce the production of both steroid and peptide hormones in human choriocarcinoma cells. Here, we attempted to investigate the role and un...
Inhibition of phosphatase and tensin homologue (PTEN) in human ovary in vitro results in increased activation of primordial follicles but compromises development of growing follicles [0.03%]
人卵巢体外抑制磷脂和张力蛋白同源物（PTEN）可增加始基卵泡激活但损害生长卵泡发育
Marie McLaughlin,Hazel L Kinnell,Richard A Anderson et al.
Marie McLaughlin et al.
In the mammalian ovary a small number of follicles are steadily recruited from the quiescent pool to undergo development. Follicle loss, maintenance and growth are strictly controlled by complex molecular interactions including the phosphoi...
Matrix metalloproteinase-27 is expressed in CD163+/CD206+ M2 macrophages in the cycling human endometrium and in superficial endometriotic lesions [0.03%]
基质金属蛋白酶27在子宫内膜异位症病灶中表达
Antoine Cominelli,Héloïse P Gaide Chevronnay,Pascale Lemoine et al.
Antoine Cominelli et al.
Matrix metalloproteinases (MMPs) are key enzymes involved in extracellular matrix remodelling. In the human endometrium, the expression and activity of several MMPs are maximal during the menstrual phase. Moreover, MMPs are thought to be in...
Galectin-7 is important for normal uterine repair following menstruation [0.03%]
GM7糖 lectin-7在月经后正常子宫修复中起重要作用
Jemma Evans,Joanne Yap,Thillini Gamage et al.
Jemma Evans et al.
Menstruation involves the shedding of the functional layer of the endometrium in the absence of pregnancy. At sites where tissue shedding is complete, re-epithelialization of the tissue is essential for repair and termination of bleeding. T...