ERK1/2 is involved in luteal cell autophagy regulation during corpus luteum regression via an mTOR-independent pathway [0.03%]
ERK1/2通过mTOR非依赖性途径参与黄体退化过程中黄体细胞自噬的调节
JongYeob Choi,MinWha Jo,EunYoung Lee et al.
JongYeob Choi et al.
Autophagy is known to be regulated by the phosphoinositide-3 kinase (PI3K)-protein kinase B (AKT) and/or mitogen-activated protein kinase 1/2 (MEK1/2)-extracellular signal-regulated kinase 1/2 (ERK1/2) pathways, leading to activation of mam...
CCR5 expression is elevated in cervical cancer cells and is up-regulated by seminal plasma [0.03%]
CCR5在宫颈癌细胞中的表达升高，并可被精液上调
Kurt J Sales,Anthonio Adefuye,Lauren Nicholson et al.
Kurt J Sales et al.
The interplay between inflammation, cervical cancer and HIV acquisition in women is poorly understood. We have previously shown that seminal plasma (SP) can promote cervical tumour cell growth in vitro and in vivo via the activation of pote...
Involvement of doublesex and mab-3-related transcription factors in human female germ cell development demonstrated by xenograft and interference RNA strategies [0.03%]
双性基因和mab-3相关转录因子通过人源细胞异种移植及RNA干扰技术在小鼠体内参与人类卵母细胞发生的功能研究
Marine Poulain,Nelly Frydman,Sophie Tourpin et al.
Marine Poulain et al.
We identified three doublesex and mab-3-related transcription factors (DMRT) that were sexually differentially expressed in human fetal gonads and present in the ovaries at the time of meiotic initiation. These were also identified in murin...
Ha Thi Nguyen,Christina Markouli,Mieke Geens et al.
Ha Thi Nguyen et al.
It is well known that human embryonic stem cells (hESCs) frequently acquire recurrent chromosomal abnormalities, very reminiscent of those found in cancerous cells. Given the parallels between cancer and stem cell biology, we set out to inv...
NLRP7 inter-domain interactions: the NACHT-associated domain is the physical mediator for oligomeric assembly [0.03%]
NLRP7跨域相互作用：NACHT相关结构域是寡聚组装的物理介体
Heike Singer,Arijit Biswas,Nicole Zimmer et al.
Heike Singer et al.
Mutations in NLRP7 (NOD-like-receptor family, pyrin domain containing 7) are responsible for a type of recurrent pregnancy loss known as recurrent hydatidiform mole (HYDM1). This condition is characterized by abnormal growth of the placenta...
Docetaxel induces moderate ovarian toxicity in mice, primarily affecting granulosa cells of early growing follicles [0.03%]
多西他赛诱导小鼠中等程度的卵巢毒性主要影响早期生长卵泡的颗粒细胞
Federica Lopes,Rowena Smith,Richard A Anderson et al.
Federica Lopes et al.
Advances in cancer therapy have focused attention on the quality of life of cancer survivors. Since infertility is a major concern following chemotherapy, it is important to characterize the drug-specific damage to the reproductive system t...
Sperm-specific post-acrosomal WW-domain binding protein (PAWP) does not cause Ca2+ release in mouse oocytes [0.03%]
精子特异性尾部WW结构结合蛋白(PAWP)不能在小鼠卵细胞中引起钙离子释放
Michail Nomikos,Jessica R Sanders,Maria Theodoridou et al.
Michail Nomikos et al.
Mature mammalian oocytes undergo a prolonged series of cytoplasmic calcium (Ca(2+)) oscillations at fertilization that are the cause of oocyte activation. The Ca(2+) oscillations in mammalian oocytes are driven via inositol 1,4,5-trisphosph...
Epigenetic mechanisms regulate placental c-myc and hTERT in normal and pathological pregnancies; c-myc as a novel fetal DNA epigenetic marker for pre-eclampsia [0.03%]
表观遗传机制调节正常和病理妊娠中的胎盘c-myc和hTERT；c-myc作为先兆子痫表观遗传标志的新型胎儿DNA标记物
Beenish Rahat,Abid Hamid,Rauf Ahmad Najar et al.
Beenish Rahat et al.
Placental development is known for its resemblance with tumor development, such as in the expression of oncogenes (c-myc) and telomerase (hTERT). The expression of c-myc and hTERT is up-regulated during early pregnancy and gestational troph...
A peptide inhibitor of synuclein-γ reduces neovascularization of human endometriotic lesions [0.03%]
人子宫内膜异位病灶新生血管形成的Synuclein-γ多肽抑制剂
Andrew Kenneth Edwards,Sharanya Ramesh,Vinay Singh et al.
Andrew Kenneth Edwards et al.
Endometriosis is a chronic painful gynecological condition characterized by adherence and growth of endometrium outside of the uterine cavity. Neovascularization is essential to the developing endometriosis lesion to support its growth. Syn...
High-resolution helium ion microscopy of epididymal epithelial cells and their interaction with spermatozoa [0.03%]
高分辨率氦离子显微镜下的附睾上皮细胞及其与精子的相互作用
Teodor G Păunescu,Winnie W C Shum,Chuong Huynh et al.
Teodor G Păunescu et al.
We examined the rat and mouse epididymis using helium ion microscopy (HIM), a novel imaging technology that uses a scanning beam of He(+) ions to produce nanometer resolution images of uncoated biological samples. Various tissue fixation, s...