Steven A Ramm,Lukas Schärer,Jens Ehmcke et al.
Steven A Ramm et al.
Spermatogenesis is a long and complex process that, despite the shared overall goal of producing the male gamete, displays striking amounts of interspecific diversity. In this review, we argue that sperm competition has been an important se...
John L Fitzpatrick,Stefan Lüpold
John L Fitzpatrick
Sperm experience intense and varied selection that dramatically impacts the evolution of sperm quality. Selection acts to ensure that sperm are fertilization-competent and able to overcome the many challenges experienced on their way toward...
Sperm competition and the evolution of gametic compatibility in externally fertilizing taxa [0.03%]
精子竞争与外 fertilizing 税收的合性进化
E T Kosman,D R Levitan
E T Kosman
Proteins expressed on the surface of sperm and egg mediate gametic compatibility and these proteins can be subject to intense positive selection. In this review, we discuss what is known about the patterns of adaptive evolution of gamete re...
Reliable pre-eclampsia pathways based on multiple independent microarray data sets [0.03%]
基于多个独立基因芯片数据集的可靠子痫前期通路
Kaoru Kawasaki,Eiji Kondoh,Yoshitsugu Chigusa et al.
Kaoru Kawasaki et al.
Pre-eclampsia is a multifactorial disorder characterized by heterogeneous clinical manifestations. Gene expression profiling of preeclamptic placenta have provided different and even opposite results, partly due to data compromised by vario...
Statins inhibit insulin-like growth factor action in first trimester placenta by altering insulin-like growth factor 1 receptor glycosylation [0.03%]
他汀类药物通过改变第一胎盘 trimester placenta 的胰岛素样生长因子 1 受体糖基化抑制胰岛素样生长因子的作用
Karen Forbes,Vinit K Shah,Kirk Siddals et al.
Karen Forbes et al.
The rapid rise in obesity, metabolic syndrome and type 2 diabetes is one of the major healthcare problems of the Western world. Affected individuals are often treated with statins (3-hydroxy-3-methylglutaryl co-enzyme A [HMG CoA] reductase ...
Sexual selection and the adaptive evolution of PKDREJ protein in primates and rodents [0.03%]
性选择驱动原猴类和啮齿目PKDREJ蛋白的适应性进化
Alberto Vicens,Laura Gómez Montoto,Francisco Couso-Ferrer et al.
Alberto Vicens et al.
PKDREJ is a testis-specific protein thought to be located on the sperm surface. Functional studies in the mouse revealed that loss of PKDREJ has effects on sperm transport and the ability to undergo an induced acrosome reaction. Thus, PKDRE...
Exogenous thymine DNA glycosylase regulates epigenetic modifications and meiotic cell cycle progression of mouse oocytes [0.03%]
外源性胸腺嘧啶DNA甘露糖酶调节小鼠卵母细胞表观遗传修饰及减数分裂细胞周期进程
Jun-Yu Ma,Kun Zhao,Ying-Chun OuYang et al.
Jun-Yu Ma et al.
In mammalian cells, 5-methylcytosine (5-meC) can be transformed into 5-hydroxymethylcytosine (5-hmC) by the methylcytosine dioxygenase TET proteins (TET1, TET2 and TET3). Thymine DNA glycosylase (TDG), a downstream enzyme of TET proteins, n...
Mitochondrial DNA analysis and numerical chromosome condition in human oocytes and polar bodies [0.03%]
人卵母细胞和极体的线粒体DNA分析与整倍体检测
Luca Gianaroli,Donata Luiselli,Anna Maria Crivello et al.
Luca Gianaroli et al.
To investigate the mitochondrial DNA (mtDNA) segregation in human oocytes, the level of heteroplasmy in the three products of meioses, polar bodies (PBs) and corresponding oocytes, was assessed by studying the hypervariable region I (HVRI) ...
AMPK up-activation reduces motility and regulates other functions of boar spermatozoa [0.03%]
活化AMPK减少公猪精子运动并调节其他功能
A Hurtado de Llera,D Martin-Hidalgo,M C Gil et al.
A Hurtado de Llera et al.
We recently demonstrated that AMPK inhibition in spermatozoa regulates motility, plasma membrane organization, acrosome integrity and mitochondrial membrane potential. As AMPK activity varies in different energy conditions induced by sperm ...
Elastin-derived peptides stimulate trophoblast migration and invasion: a positive feedback loop to enhance spiral artery remodelling [0.03%]
弹性肽刺激滋养细胞迁移和侵袭：增强螺旋动脉重塑的正反馈循环
Michelle Desforges,Lynda K Harris,John D Aplin
Michelle Desforges
Elastin breakdown in the walls of uterine spiral arteries during early pregnancy facilitates their transformation into dilated, high-flow, low-resistance channels. Elastin-derived peptides (EDP) can influence cell migration, invasion and pr...