Endometrial stromal cell signaling and microRNA exosome content in women with adenomyosis [0.03%]
子宫腺肌病患者的子宫内膜基质细胞信号转导和微小rna外泌体含量
Margherita Zipponi,Luciana Cacciottola,Alessandra Camboni et al.
Margherita Zipponi et al.
Adenomyosis is a chronic, estrogen-driven disorder characterized by the presence of endometrial glands and stroma within the myometrium. Despite its significant impact on reproductive health and quality of life, the pathogenesis of the dise...
Gene expression analysis of ovarian follicles and stromal cells in girls with Turner syndrome [0.03%]
特纳综合征女孩卵泡和间质细胞基因表达分析
Ron Peek,Sanne van der Coelen,Marie-Madeleine Dolmans
Ron Peek
In patients with mosaic Turner syndrome, the ovarian somatic cells (granulosa and stromal cells) display a high level of aneuploidy with a 45,X karyotype, which may affect gene expression in the ovary and contribute to their reduced fertili...
mTOR inhibitors as potential therapeutics for endometriosis: a narrative review [0.03%]
mTOR抑制剂作为子宫内膜异位症潜在治疗药物的研究进展：叙述性综述
Akiko Nakamura,Yuji Tanaka,Tsukuru Amano et al.
Akiko Nakamura et al.
Mammalian target of rapamycin (mTOR) inhibitors have been used clinically as anticancer and immunosuppressive agents for over 20 years, demonstrating their safety after long-term administration. These inhibitors exhibit various effects, inc...
Understanding the heterogeneity of natural killer cells at the maternal-fetal interface: implications for pregnancy health and disease [0.03%]
胎盘母胎界面自然杀伤细胞异质性的研究进展：妊娠健康和疾病的免疫调控新视角
Yuying Zhang,Liangtao Yang,Dongyong Yang et al.
Yuying Zhang et al.
Natural killer (NK) cells are the most abundant leukocytes located at the maternal-fetal interface; they respond to pregnancy-related hormones and play a pivotal role in maintaining the homeostatic micro-environment during pregnancy. Howeve...
WD-repeat containing protein-61 regulates endometrial epithelial cell adhesion indicating an important role in receptivity [0.03%]
WD重复结构域含有蛋白61调控子宫内膜上皮细胞黏附在受容性中起重要作用
Poppy Downing,Madeleine Howe,Michaela Sacco et al.
Poppy Downing et al.
Endometrial receptivity is crucial for successful embryo implantation during early pregnancy. The human endometrium undergoes remodeling within each menstrual cycle to prepare or become receptive to an implanting blastocyst in the mid-secre...
Placental gene therapy in nonhuman primates: a pilot study of maternal, placental, and fetal response to non-viral, polymeric nanoparticle delivery of IGF1 [0.03%]
非病毒聚合物纳米颗粒介导的非人灵长类动物胎盘基因治疗：母体、胎盘及胎儿对IGF1递送的反应的初步研究
Rebecca L Wilson,Jenna Kropp Schmidt,Baylea N Davenport et al.
Rebecca L Wilson et al.
Currently, there are no placenta-targeted treatments to alter the in utero environment for administration to pregnant women who receive a diagnosis of fetal growth restriction (FGR). Water-soluble polymers have a distinguished record of cli...
Interleukin-22 improves ovulation in polycystic ovary syndrome via STAT3 signaling [0.03%]
白细胞介素-22通过STAT3信号改善多囊卵巢综合征排卵功能研究
Baoying Liao,Weixuan Chen,Xinyu Qi et al.
Baoying Liao et al.
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease, which leads to serious impairment of reproductive health in women of child-bearing age. Anovulation or oligo-ovulation is a common clinical manifestation of PCOS p...
Reduced expression of SMAD7 and consequent reduction of autophagy promotes endometrial stromal-myofibroblast transition and fibrosis [0.03%]
SMAD7表达下调所致自噬抑制促进子宫内膜基质肌成纤维细胞化及纤维化
Min Yong,Honggui Zhou,Yuhua Zeng et al.
Min Yong et al.
Abnormal autophagy and the transforming growth factor-β (TGFβ)-SMAD3/7 signaling pathway play an important role in the development of intrauterine adhesions (IUAs); however, the exact underlying mechanisms remain unclear. In this study, w...
Sperm-carried IGF2: towards the discovery of a spark contributing to embryo growth and development [0.03%]
精子携带的IGF2：寻找促进胚胎生长和发育因素的研究
Rossella Cannarella,Oliver J Rando,Rosita A Condorelli et al.
Rossella Cannarella et al.
Spermatozoa have been shown to carry key RNAs which, according to animal evidence, seem to play a role in early embryo development. In this context, a potential key growth regulator is insulin-like growth factor 2 (IGF2), a highly conserved...