Reply 1: Correlation between high FSH levels and increased risk of aneuploidy: the origin of the hypothesis [0.03%]
来信回复：高水平FSH与非整倍体风险增加的相关性：假说的起源
Jose Buratini,Mariabeatrice Dal Canto,Mario Mignini Renzini et al.
Jose Buratini et al.
Obesity-associated non-oxidative genotoxic stress alters trophoblast turnover in human first-trimester placentas [0.03%]
肥胖相关非氧化性致突变压力改变人类早期胎盘滋养细胞更新
Denise Hoch,Alejandro Majali-Martinez,Julia Bandres-Meriz et al.
Denise Hoch et al.
Placental growth is most rapid during the first trimester (FT) of pregnancy, making it vulnerable to metabolic and endocrine influences. Obesity, with its inflammatory and oxidative stress, can cause cellular damage. We hypothesized that ma...
Oocyte-specific EXOC5 expression is required for mouse oogenesis and folliculogenesis [0.03%]
EXOC5的卵母细胞特异性表达对小鼠卵泡发生及卵母细胞发育是必需的
Hongwen Wu,Hieu Nguyen,Prianka H Hashim et al.
Hongwen Wu et al.
EXOC5 is a crucial component of a large multi-subunit tethering complex, the exocyst complex, that is required for fusion of secretory vesicles with the plasma membrane. Exoc5 deleted mice die as early embryos. Therefore, to determine the r...
The timing of pronuclear transfer critically affects the developmental competence and quality of embryos [0.03%]
卵核移植的时机影响胚胎的发育潜能和质量
Tereza Znachorova,Nataliia Dudko,Hao Ming et al.
Tereza Znachorova et al.
Pronuclear transfer has been successfully used in human-assisted reproduction to suppress the adverse effects of a defective oocyte cytoplasm or to bypass an idiopathic developmental arrest. However, the effects of the initial parental geno...
SUN5 interacts with nuclear membrane LaminB1 and cytoskeletal GTPase Septin12 mediating the sperm head-and-tail junction [0.03%]
太阳五通过介导精子头部-尾部连接与核膜层粘连蛋白B1和细胞骨架GTP酶Septin12相互作用
Yunfei Zhang,Gang Liu,Lihua Huang et al.
Yunfei Zhang et al.
Acephalic spermatozoa syndrome (ASS) is a severe teratospermia with decaudated, decapitated, and malformed sperm, resulting in male infertility. Nuclear envelope protein SUN5 localizes to the junction between the sperm head and tail. Mutati...
Single-cell proteomics reveals decreased abundance of proteostasis and meiosis proteins in advanced maternal age oocytes [0.03%]
单细胞蛋白质组学揭示卵母细胞中蛋白质稳态和减数分裂相关蛋白含量随着母亲年龄的增长而减少
Styliani Galatidou,Aleksandra A Petelski,Aïda Pujol et al.
Styliani Galatidou et al.
Advanced maternal age is associated with a decline in oocyte quality, which often leads to reproductive failure in humans. However, the mechanisms behind this age-related decline remain unclear. To gain insights into this phenomenon, we app...
Reina Komatsu,Hitomi Nakamura,Takayoshi Hosono et al.
Reina Komatsu et al.
Preterm birth is a serious pregnancy complication that affects neonatal mortality, morbidity, and long-term neurological prognosis. Predicting spontaneous preterm delivery (PTD) is important for its management. While excluding the risk of P...
Murine uterine gland branching is necessary for gland function in implantation [0.03%]
小鼠子宫腺分支是受精卵着床时发挥腺体功能的必要条件
Katrina Granger,Sarah Fitch,May Shen et al.
Katrina Granger et al.
Uterine glands are branched, tubular structures whose secretions are essential for pregnancy success. It is known that pre-implantation glandular expression of leukemia inhibitory factor (LIF) is crucial for embryo implantation; however, th...
Extracellular vesicles secreted by cumulus cells contain microRNAs that are potential regulatory factors of mouse oocyte developmental competence [0.03%]
放射冠细胞分泌的外泌体含有小RNA分子，这些分子可能是小鼠卵母细胞发育潜能的调控因子
Giulia Fiorentino,Valeria Merico,Mario Zanoni et al.
Giulia Fiorentino et al.
The role of cumulus cells (CCs) in the acquisition of oocyte developmental competence is not yet fully understood. In a previous study, we matured cumulus-denuded fully-grown mouse oocytes to metaphase II (MII) on a feeder layer of CCs (FL-...