Placental gene therapy in nonhuman primates: a pilot study of maternal, placental, and fetal response to non-viral, polymeric nanoparticle delivery of IGF1 [0.03%]
非病毒聚合物纳米颗粒介导的非人灵长类动物胎盘基因治疗：母体、胎盘及胎儿对IGF1递送的反应的初步研究
Rebecca L Wilson,Jenna Kropp Schmidt,Baylea N Davenport et al.
Rebecca L Wilson et al.
Currently, there are no placenta-targeted treatments to alter the in utero environment for administration to pregnant women who receive a diagnosis of fetal growth restriction (FGR). Water-soluble polymers have a distinguished record of cli...
Interleukin-22 improves ovulation in polycystic ovary syndrome via STAT3 signaling [0.03%]
白细胞介素-22通过STAT3信号改善多囊卵巢综合征排卵功能研究
Baoying Liao,Weixuan Chen,Xinyu Qi et al.
Baoying Liao et al.
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease, which leads to serious impairment of reproductive health in women of child-bearing age. Anovulation or oligo-ovulation is a common clinical manifestation of PCOS p...
Reduced expression of SMAD7 and consequent reduction of autophagy promotes endometrial stromal-myofibroblast transition and fibrosis [0.03%]
SMAD7表达下调所致自噬抑制促进子宫内膜基质肌成纤维细胞化及纤维化
Min Yong,Honggui Zhou,Yuhua Zeng et al.
Min Yong et al.
Abnormal autophagy and the transforming growth factor-β (TGFβ)-SMAD3/7 signaling pathway play an important role in the development of intrauterine adhesions (IUAs); however, the exact underlying mechanisms remain unclear. In this study, w...
Sperm-carried IGF2: towards the discovery of a spark contributing to embryo growth and development [0.03%]
精子携带的IGF2：寻找促进胚胎生长和发育因素的研究
Rossella Cannarella,Oliver J Rando,Rosita A Condorelli et al.
Rossella Cannarella et al.
Spermatozoa have been shown to carry key RNAs which, according to animal evidence, seem to play a role in early embryo development. In this context, a potential key growth regulator is insulin-like growth factor 2 (IGF2), a highly conserved...
Maturational competence of equine oocytes is associated with alterations in their 'cumulome' [0.03%]
与卵母细胞的“Cumulome”变化相关的马卵母细胞发育成熟能力的研究
Jasmin Walter,Silvia Colleoni,Giovanna Lazzari et al.
Jasmin Walter et al.
Assisted reproductive technologies are an emerging field in equine reproduction, with species-dependent peculiarities, such as the low success rate of conventional IVF. Here, the 'cumulome' was related to the developmental capacity of its c...
Adjusting methylation levels with nucleus proportions highlights functional significance of differentially methylated cytosines associated with pre-eclampsia [0.03%]
使用核素比例调整甲基化水平以突出与子痫前期相关的差异性甲基化胞嘧啶的功能意义
Xiaoguo Zheng,Yanqin Wen,Xinzhi Zhao
Xiaoguo Zheng
Studies on DNA methylation alterations associated with pre-eclampsia (PE) have improved our understanding of the mechanisms underlying this disorder. However, differentially methylated cytosines (DMCs) have not been adjusted for cell-type h...
Variants in NLRP2 and ZFP36L2, non-core components of the human subcortical maternal complex, cause female infertility with embryonic development arrest [0.03%]
NLRP2和ZFP36L2基因变异导致胚胎发育停滞型女性不孕症
Ximan Rui,Xiaolan Zhang,Xinru Jia et al.
Ximan Rui et al.
The subcortical maternal complex (SCMC), which is vital in oocyte maturation and embryogenesis, consists of core proteins (NLRP5, TLE6, OOEP), non-core proteins (PADI6, KHDC3L, NLRP2, NLRP7), and other unknown proteins that are encoded by m...
Reply 2: Correlation between high FSH levels and increased risk of aneuploidy: the origin of the hypothesis [0.03%]
来信回复 2：高FSH水平与非整倍体风险增加之间的关系：假说的起源
Lori R Bernstein,Amelia C L Mackenzie,Charles L Chaffin et al.
Lori R Bernstein et al.