Aberrant Progesterone Receptor (PGR) expression is associated with Estrogen Receptor 1 (ESR1) expression in the endometrium from infertile women with endometriosis [0.03%]
异常孕酮受体(PGR)与不孕症且患有子宫内膜异位症的女性子宫内膜雌激素受体1(ESR1)表达的关系研究
Sohyeon Yun,Soo Lim Kim,Eunhee M Jeong et al.
Sohyeon Yun et al.
Estrogen receptor 1 (ESR1) and progesterone receptor (PGR) are essential regulators for endometrial receptivity and embryo implantation. Their expression is dysregulated in women with endometriosis-associated infertility. However, the relat...
Variable partition of non-homogeneous ooplasm sets the stage for divergent potency of 2-cell stage blastomeres [0.03%]
不均一卵黄质的可变式分区决定了二细胞期胚胎两个卵裂球发育潜能的差异性
Thomas Nolte,Reza Halabian,Steffen Israel et al.
Thomas Nolte et al.
Following fertilization in mice and humans, the first two blastomeres are not equivalent, but one produces more epiblast than the other (imbalance), therefore, they do not feature equal totipotency. Research into the causes has overlooked t...
Isha Ramanlal,Joanna L James,Anna L Boss
Isha Ramanlal
Maternal obesity is complicating an increasing number of pregnancies globally and is associated with a heightened risk of adverse obstetric and fetal outcomes. The placenta, which mediates maternal-fetal exchange, is postulated to be a key ...
Embryo secretome regulation of the endometrial epithelial transcriptome: development of a model to test for embryo viability [0.03%]
胚胎外分泌调节子宫内膜上皮转录组：检测胚胎活力模型的建立
Zhixing Jin,Yifan Wang,Abigail Freeman Blatchford et al.
Zhixing Jin et al.
The aim of this study was to develop an advanced in vitro model of human endometrium using single-cell derived endometrial epithelial organoids, enabling the study of embryo secretome-endometrial crosstalk at the maternal-fetal interface. S...
Preeclampsia 2.0: Limitations and challenges of the two-stage hypothesis, and beyond [0.03%]
子痫前期2.0：两阶段假说的局限性、挑战及展望
Berthold Huppertz
Berthold Huppertz
The pregnancy-specific syndrome preeclampsia remains the syndrome of hypotheses. Still, there is not a single hypothesis explaining the etiology of the full spectrum of preeclampsia. This has direct consequences for the clinical management ...
Deconvolution of DNA Methylation Data Reveals Cell-Type-Specific Epigenomic Signatures in Endometriosis and Eutopic Endometrium [0.03%]
DNA甲基化数据的解卷积可揭示子宫内膜异位症和自体子宫内膜中的细胞类型特异性表观遗传特征
Yucheng Wang,Patricia A Shaw,Camille K Boufford et al.
Yucheng Wang et al.
Endometriosis (EM) is a debilitating disease involving the growth of endometrial glands and stroma outside the uterus. To further our understanding of epigenomic dysregulation in EM and search for disease biomarkers, we performed a comprehe...
MRP4 transporter is involved in the acquisition of human sperm's fertilizing ability [0.03%]
MRP4转运体参与获取人类精子受精能力
Sofia Río,Tomás J Steeman,Cristian Dotto et al.
Sofia Río et al.
Cyclic AMP (cAMP) regulates multiple aspects of sperm function essential for attaining fertilizing ability; therefore, its intracellular levels must be tightly controlled to ensure proper signaling dynamics. In recent years, multidrug resis...
Fertilization Failure Assay Identifies Stage-Specific Arrests in Couples with Total Fertilization Failure [0.03%]
受精失败分析鉴定出完全受精失败夫妇中特定时期的停滞现象
Jing Dai,Yueren Wu,Jianfang Che et al.
Jing Dai et al.
Fertilization is the process by which sperm and oocyte recognize each other and fuse to form a zygote. Fertilization failure is a common issue encountered in ART. However, clinically, there is a lack of identification of the specific stage ...
Temporal dynamics of uterine immune microenvironment remodeling in a murine model of adenomyosis [0.03%]
小鼠子宫腺肌病模型中子宫免疫微环境重塑的动态变化特征研究
Marlyne Squatrito,Julie Vervier,Laëtitia Bernet et al.
Marlyne Squatrito et al.
Adenomyosis-the ectopic presence of endometrial glands and stroma within the myometrium-affects reproductive-age women and is associated with pain, bleeding, and subfertility, yet the immune events that precede pregnancy remain poorly defin...
Beyza Gaye Edepli,Aylin Yaba
Beyza Gaye Edepli
Ovarian fibrosis is increasingly recognized as a pivotal factor contributing to ovarian aging, dysfunction and female infertility. It results from chronic or repetitive ovarian injury, such as that caused by repeated ovulation, which induce...