Mechanical signal-mediated mitochondria-endoplasmic reticulum contacts modulate Leydig cell testosterone biosynthesis during testis development [0.03%]
机械信号介导的线粒体-内质网接触在睾丸发育过程中调节类固醇分泌和间质细胞雄激素生物合成
Jiahong Wu,Ruiling He,Zeyu Xu et al.
Jiahong Wu et al.
In males, 95% of testosterone is synthesized by Leydig cells, and a deficiency in this synthesis will cause metabolic disorders and multiple organ dysfunction. Testosterone deficiency is not only affected by aged or diseased Leydig cells, w...
Alterations in the abundance of protamine proteoforms related to sperm chromatin packaging, obesity and age in normozoospermic men [0.03%]
正常精子生成男性的组蛋白乙酰化和精胺甲基化状态与肥胖和年龄的关系研究
Judit Castillo,Marina Gay,Alberto De La Iglesia et al.
Judit Castillo et al.
Protamines are considered among the most relevant sperm proteins because of their functional implications on paternal genome packaging and protection. Although the proteomic evaluation of protamines is technically challenging, mass spectrom...
Mosaicism is more than meets the eye: transcriptional consequences of blastocyst mosaicism [0.03%]
mosaicism的转录后效应：囊胚期mosaicism的后果
Brandon A Wyse,Noga Fuchs Weizman,Rima Kharonsky et al.
Brandon A Wyse et al.
Blastocyst mosaicism is increasingly detected due to advances in preimplantation genetic testing for aneuploidy (PGT-A). While some mosaic embryos result in a live birth, there are reports of altered implantation potential. Various approach...
Single-cell metabolomics reveals that bisphosphoglycerate mutase influences oocyte maturation through glucose metabolism [0.03%]
单细胞代谢组学揭示二磷酸甘油酸互变异构酶通过糖酵解影响卵母细胞成熟
Jing Wang,Qiang Liu,Zhiqiang Yan et al.
Jing Wang et al.
The spatiotemporal turnover of metabolites is essential for oocyte maturation, embryonic development, and cell lineage differentiation. Here, we analyzed the metabolic profiles of individual living mouse oocytes and studied how bisphosphogl...
Cellular Prion: A novel regulator of decidual cell function at the maternal fetal interface [0.03%]
细胞型朊病毒：一种新的调节母胎界面蜕膜细胞功能因子
Swarnali Dey,Tamal Kanti Gope,Rupasri Ain
Swarnali Dey
Cellular prion (PRNP) is a GPI anchored extrinsic membrane glycoprotein, which has been implicated in mouse decidualization. However, the molecular function of this protein, in mouse decidua is not known. In this report, we have characteriz...
Roles of chromosomal and gonadal sex in the fetal and placental responses to maternal food restriction in mice [0.03%]
小鼠母体营养限制对胎儿和胎盘性别二态反应的遗传学机制研究
Jess C Hercus,Daniel Alejandro Salcedo Rubio,Maria Elisa Osorio Nieto et al.
Jess C Hercus et al.
It is hypothesized that male fetuses are more vulnerable to in utero insults than females due to different growth strategies, and that the placenta contributes to these sex differences. We examined sex differences in the fetal and placental...
OTUD1 inhibits endometriosis fibrosis by deubiquitinating MADH7 [0.03%]
OTUD1通过去泛素化MADH7抑制子宫内膜异位症纤维化
Xiangyu Chang,Yanqin Zhang,Mengqi Deng et al.
Xiangyu Chang et al.
Fibrosis constitutes the principal pathophysiological mediator of pain and infertility manifestations in endometriosis, and the inhibitory factor of TGF-β pathway, MADH7, makes a vital impact on the progression of fibrosis. Ovarian tumour ...
Effects of chronic particulate matter exposure on endometriosis-associated signaling pathways and disease progression [0.03%]
慢性颗粒物暴露对子宫内膜异位症相关信号通路和疾病进展的影响
Gee Soo Jung,Jae Hoon Lee,Min Jung Lee et al.
Gee Soo Jung et al.
Exposure to PM2.5 (particulate matter
Correction to: Understanding the heterogeneity of natural killer cells at the maternal-fetal interface: implications for pregnancy health and disease [0.03%]
Correction to:理解自然杀伤细胞在母胎界面的异质性：对妊娠健康和疾病的启示
Published Erratum
Molecular human reproduction. 2025 Apr 3;31(2):gaaf010. DOI:10.1093/molehr/gaaf010 2025
Exploring and validating the marmoset as a primate model for chromosomal instability in early development [0.03%]
早期发育过程中以染色体不稳定为特征的非人灵长类模型狨猴的研究与验证
Andrew Cearlock,Hubert Mysliwiec,Margarita Agarsheva et al.
Andrew Cearlock et al.
Aneuploidy in embryos poses a major barrier to successful human reproduction, contributing to nearly 50% of early miscarriages. Despite its high prevalence in human embryos, the molecular mechanisms regulating aneuploid cell fate during dev...