WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Organoids): endometrial organoids as an emerging technology for endometriosis research [0.03%]
外阴痕形成表型和生物信息库协调项目（EPHect-EM-类器官）：子宫内膜类器官作为研究子宫内膜的新技术
Elizabeth E Marr,Juan S Gnecco,Stacey A Missmer et al.
Elizabeth E Marr et al.
The aetiology of endometriosis remains poorly understood. In vitro model systems provide the opportunity to identify the mechanisms driving disease pathogenesis using human cells. Three-dimensional models, particularly organoid systems, hav...
WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Homologous): homologous rodent models [0.03%]
子宫内膜异位症表型和生物样本库协调项目（EPHect-EM-Homologous）：同种动物模型在子宫内膜异位症研究中的应用
Katherine A Burns,Daniëlle Peterse,Caroline B Appleyard et al.
Katherine A Burns et al.
In vivo models of endometriosis enable the discovery and preclinical testing of new therapies. Several rodent models of endometriosis exist, but a lack of harmonization impedes reproducibility and comparability of results among investigator...
WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Pain): methods to assess pain behaviour in rodent models of endometriosis [0.03%]
内异症研究中实验模型的内异症表型和生物信息库协调项目（EPHect-EM-Pain）：评估内异症动物模型疼痛行为的方法学
Kelsi N Dodds,Victor Fattori,Nick A Andrews et al.
Kelsi N Dodds et al.
Pain is a debilitating symptom of endometriosis, and its mechanisms are often explored using rodent models. However, a lack of harmonization amongst models and behavioural measures, in addition to inconsistent reporting, might limit the ove...
Enhancing collaboration in endometriosis research through the initiative of the World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project (EPHect) [0.03%]
世界子宫内膜异位症研究基金会子宫内膜异位症表型和生物信息库协调项目（EPHect）通过发起倡议促进子宫内膜异位症研究中的合作
Lone Hummelshoj,Daniëlle Peterse,Kaylon L Bruner-Tran et al.
Lone Hummelshoj et al.
TTBK2 affects sperm quality by regulating the expression of centrosomal proteins and flagellar transporters during spermiogenesis in mice [0.03%]
TBRK2通过调节小鼠精子生成过程中中心体蛋白和鞭毛转运蛋白的表达影响精子质量
Tianqing Chang,Hua Wu,Xinyue Zhang et al.
Tianqing Chang et al.
Sperm plays a crucial role in male reproduction and only a certain number of normal progressive sperm can achieve oocyte fertilization. Revealing the regulatory mechanism of spermatogenesis will help to clarify the pathogenesis of male infe...
Lysine methyltransferase SETD7 coordinates the emergence of mature and senescent subpopulations during the decidualization of endometrial stromal cells [0.03%]
赖氨酸甲基转移酶SETD7在内膜间质细胞蜕膜化过程中调控成熟和衰老亚群的产生
Аlina O Konyushatova,Pavel I Deryabin,Anastasia P Melnik et al.
Аlina O Konyushatova et al.
Stepwise decidualization of endometrial stromal cells (EnSC) mediates the ability of the endometrium to respond to embryo quality, determining whether to permit or restrict its implantation. Currently, epigenetic mechanisms are recognized a...
A matrix-free 3D in vitro follicle culture system in mice exhibits enhanced oocyte meiotic and developmental competence compared to hydrogel encapsulation [0.03%]
一种无矩阵的三维体外卵泡培养系统比水凝胶包埋培养在小鼠中表现出增强的卵母细胞减数分裂能力和发育能力
Aimilia Zisiadi,Katy Billooye,Ellen Anckaert
Aimilia Zisiadi
In vitro follicle culture (IFC) is an emerging fertility preservation alternative for women and children with cancer. Because two-dimensional (2D) IFC results in oocytes of suboptimal quality in mice and cannot support follicle growth in hu...
Eutopic macrophages facilitate endometriosis progression via ferroptosis-mediated release of S100A9 [0.03%]
铁死亡介导的S100A9释放促进异位巨噬细胞促进子宫内膜异位症进展
Chunying Ye,Panmei Ma,Nana Li et al.
Chunying Ye et al.
Endometriosis is a chronic inflammatory disorder in which immune cells, specifically macrophages, play a pivotal yet incompletely understood role. Aberrations within the eutopic endometrium are implicated in the initiation and progression o...
Overexpression of high affinity Type I adenosine receptors promotes the growth of uterine leiomyomas [0.03%]
I型高亲和力腺苷受体过度表达促进子宫平滑肌瘤的生长
Rodrigo Rosado,Xiaofang Guo,Jake Rymer et al.
Rodrigo Rosado et al.
Leiomyomas are benign proliferations of uterine smooth muscle found in 60% of women. A spatial redistribution of ecto-5'-nucleotidase (CD73, NT5E) that results in reduced extracellular concentrations of adenosine has recently been described...
Early signaling pathways during in vitro culture of isolated primordial follicles [0.03%]
体外培养卵原基窦状小 follicle早期信号通路的研究
Pritha Dey,Noemi Monferini,Ludovica Donadini et al.
Pritha Dey et al.
The ability to grow undifferentiated oocytes in vitro from primordial follicles would increase the availability of fully grown oocytes in fertility preservation programs and other downstream applications. To date, the development of living ...