An aberrant protamine ratio is associated with decreased H4ac levels in murine and human sperm [0.03%]
异常的精蛋白比例与小鼠和人类精子中的H4ac水平降低有关
Alexander Kruse,Simon Schneider,Gina Esther Merges et al.
Alexander Kruse et al.
Protamine 2 (Prm2/PRM2), together with Protamine 1 (Prm1/PRM1), constitute the two protamines found in both murine and human sperm. During spermiogenesis in haploid male germ cells, chromatin undergoes significant condensation, a phase in w...
Mouse modeling of familial human SYCE1 c.197-2A>G splice site mutation leads to meiotic recombination failure and non-obstructive azoospermia [0.03%]
SYCE1基因内含子剪切位点突变导致了联会失败及非梗阻性无精子症的小鼠模型研究
Omar Ignacio García-Martínez,Adriana Geisinger,Eliana de Los Santos et al.
Omar Ignacio García-Martínez et al.
Infertility affects a considerable number of couples at reproductive age, with an incidence of 10-15%. Approximately 25% of cases are classified as idiopathic infertility. Often, errors during the meiotic stage appear to be related to idiop...
Pro-cumulin addition in a biphasic in vitro oocyte maturation system modulates human oocyte and cumulus cell transcriptomes [0.03%]
前列腺抗凝素的添加调节人卵母细胞和放射冠细胞转录组
Berta Cava-Cami,Antonio Galvao,Heidi Van Ranst et al.
Berta Cava-Cami et al.
Biphasic in vitro oocyte maturation (IVM) can be offered as a patient-friendly alternative to conventional ovarian stimulation in in vitro fertilization (IVF) patients predicted to be hyper-responsive to ovarian stimulation. However, cumula...
Animal and vegetal materials of mouse oocytes segregate at first zygotic cleavage: a simple mechanism that makes the 2-cell blastomeres differ reciprocally from the start [0.03%]
小鼠卵母细胞的动物和植物材料在第一次合子分裂时分离：一个简单的机制，使2个卵裂球从一开始就相互不同
Thomas Nolte,Reza Halabian,Steffen Israel et al.
Thomas Nolte et al.
Recent advances in embryology have shown that the sister blastomeres of 2-cell mouse and human embryos differ reciprocally in potency. An open question is whether the blastomeres became different as opposed to originating as different. Here...
Ectopic endometrial stromal cell-derived extracellular vesicles encapsulating microRNA-25-3p induce endometrial collagen I deposition impairing decidualization in endometriosis [0.03%]
子宫内膜异位症患者外周血来源的宫腔内注射异位子宫内膜间质细胞衍生的微囊泡诱导子宫内膜I型胶原沉积及蜕膜化损伤
Yuan Zhu,Bo Zheng,Yuting Zhang et al.
Yuan Zhu et al.
Endometrial collagen I undergoes dynamic degradation and remodelling in response to endometrial stromal cell (ESC) decidualization and embryo implantation. However, excessive collagen I deposition in the endometrium during the implantation ...
Endometrial stromal cell signaling and microRNA exosome content in women with adenomyosis [0.03%]
子宫腺肌病患者的子宫内膜基质细胞信号转导和微小rna外泌体含量
Margherita Zipponi,Luciana Cacciottola,Alessandra Camboni et al.
Margherita Zipponi et al.
Adenomyosis is a chronic, estrogen-driven disorder characterized by the presence of endometrial glands and stroma within the myometrium. Despite its significant impact on reproductive health and quality of life, the pathogenesis of the dise...
Gene expression analysis of ovarian follicles and stromal cells in girls with Turner syndrome [0.03%]
特纳综合征女孩卵泡和间质细胞基因表达分析
Ron Peek,Sanne van der Coelen,Marie-Madeleine Dolmans
Ron Peek
In patients with mosaic Turner syndrome, the ovarian somatic cells (granulosa and stromal cells) display a high level of aneuploidy with a 45,X karyotype, which may affect gene expression in the ovary and contribute to their reduced fertili...
mTOR inhibitors as potential therapeutics for endometriosis: a narrative review [0.03%]
mTOR抑制剂作为子宫内膜异位症潜在治疗药物的研究进展：叙述性综述
Akiko Nakamura,Yuji Tanaka,Tsukuru Amano et al.
Akiko Nakamura et al.
Mammalian target of rapamycin (mTOR) inhibitors have been used clinically as anticancer and immunosuppressive agents for over 20 years, demonstrating their safety after long-term administration. These inhibitors exhibit various effects, inc...
Understanding the heterogeneity of natural killer cells at the maternal-fetal interface: implications for pregnancy health and disease [0.03%]
胎盘母胎界面自然杀伤细胞异质性的研究进展：妊娠健康和疾病的免疫调控新视角
Yuying Zhang,Liangtao Yang,Dongyong Yang et al.
Yuying Zhang et al.
Natural killer (NK) cells are the most abundant leukocytes located at the maternal-fetal interface; they respond to pregnancy-related hormones and play a pivotal role in maintaining the homeostatic micro-environment during pregnancy. Howeve...
WD-repeat containing protein-61 regulates endometrial epithelial cell adhesion indicating an important role in receptivity [0.03%]
WD重复结构域含有蛋白61调控子宫内膜上皮细胞黏附在受容性中起重要作用
Poppy Downing,Madeleine Howe,Michaela Sacco et al.
Poppy Downing et al.
Endometrial receptivity is crucial for successful embryo implantation during early pregnancy. The human endometrium undergoes remodeling within each menstrual cycle to prepare or become receptive to an implanting blastocyst in the mid-secre...