Metabolic, microbial, and pharmacological stimuli elicit distinct lipidomic and cytokine responses in human placenta [0.03%]
代谢、微生物和药理学刺激引起人类胎盘脂质组和细胞因子反应的区别
Fiona Kumnova,Oleksandr Kozlov,Eva Cifkova et al.
Fiona Kumnova et al.
The placenta integrates metabolic and immune functions essential for fetal development, and disruptions in lipid metabolism and inflammatory signaling have been implicated in pregnancy complications such as gestational diabetes mellitus (GD...
Call for papers-shaping reproduction in 3D: organoids, assembloids, and emerging models [0.03%]
征稿启事：三维生殖的塑造：类器官、组装体和新兴模型
Diana Monsivais,Francesca E Duncan,Michele Boiani;MHR Editorial Board
Diana Monsivais
MHR: the first 30 years [0.03%]
MHR：前三十年
Michele Boiani
Michele Boiani
Butyric acid-based self-assembling nanoparticles: a potential strategy to prevent development of polycystic ovary syndrome [0.03%]
基于丁酸的自组装纳米颗粒：预防多囊卵巢综合征发展的潜在策略
Nanoka Sakaguchi,Akari Kusamoto,Miyuki Harada et al.
Nanoka Sakaguchi et al.
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age and cannot currently be cured or prevented fundamentally. Prenatal androgen exposure is a key factor in PCOS development, and both PC...
Endometriomas are heterogeneous for functional FSH receptor expression and steroidogenic function [0.03%]
功能FSH受体表达和类固醇生成功能的异质性与子宫内膜异位囊肿有关
Can Benlioglu,Yashar Esmaeilian,Sevgi Yusufoglu et al.
Can Benlioglu et al.
We investigated whether ovarian endometriomas uniformly express functional FSH receptors (FSHR) and respond to FSH by activating transcriptional programs that drive aromatase and steroid hormone production. Endometrioma cyst capsules were o...
SARS-CoV-2 infects human primary cytotrophoblasts mainly through a non-canonical entry route [0.03%]
SARS-CoV-2主要通过非经典侵入途径感染人胎盘绒毛外细胞滋养细胞簇
Hélène Pinatel,Marie-Eve Brien,Mathilde Broquière et al.
Hélène Pinatel et al.
Since the beginning of the COVID-19 pandemic, vulnerable populations such as pregnant persons have been at higher risk of severe symptoms and poor outcomes. Although reports of SARS-CoV-2 vertical transmission remain rare, several studies s...
Stage-dependent sphingosine-1-phosphate pathway modulation as a therapeutic strategy in a murine model of adenomyosis [0.03%]
小鼠腺肌症模型中基于病变阶段的鞘氨醇-1-磷酸信号途径调控作为治疗策略研究
Marlyne Squatrito,Silvia Blacher,Julie Vervier et al.
Marlyne Squatrito et al.
Adenomyosis is characterised by chronic inflammation, myometrial remodeling and subfertility, yet therapeutic options that preserve reproductive potential remain limited. Sphingosine-1-phosphate (S1P) signaling regulates immune-cell traffic...
Angiotensin Ⅱ type 1 receptor autoantibody (AT1-AA) is involved in ovulatory disorders: AT1-AA impairs spindle and chromosome organization [0.03%]
血管紧张素Ⅱ受体自身抗体参与排卵障碍：AT1-AA影响纺锤体和染色体的排列
Yao Chen,Gui-Fang Yang,Yi-Nan Zhang et al.
Yao Chen et al.
Ovulatory disorders are a major cause of infertility. Studies have shown that the renin-angiotensin system (RAS) plays a vital role in the female reproductive system. The angiotensin Ⅱ type 1 receptor (AT1R), an important mediator of the R...
Reduced activin A levels impair urogenital system development and compromise female mouse fertility [0.03%]
激活素A水平降低影响泌尿生殖系统发育并损害雌鼠生育能力
Eliza Winek,Katarzyna Szczepańska,Marcin Bednarek et al.
Eliza Winek et al.
Activin A, encoded by the Inhba gene, is a versatile protein crucial for numerous biological processes, and its dysregulation is implicated in various human disorders. However, the perinatal lethality of Inhba knockout mice restricts the de...
Orosomucoid 2 improves reproductive phenotypes in a mouse model of PCOS induced by letrozole under high-fat diet conditions [0.03%]
高脂饮食诱导的来曲唑PCOS小鼠模型中ORMD1改善多囊卵巢综合征表型
Qiuyu Xu,Shuwen Qiu,Li Wang et al.
Qiuyu Xu et al.
PCOS is the most common reproductive endocrine disorder among women of reproductive age. It is characterized by excess androgens, anovulation, and polycystic ovarian morphology, and is often accompanied by obesity, insulin resistance and gl...