Alterations of endometrial epithelial-mesenchymal transition and MAPK signalling components in women with PCOS are partially modulated by metformin in vitro [0.03%]
二甲双胍部分调节PCOS患者子宫内膜上皮间质转化及MAPK信号组件的改变
Min Hu,Yuehui Zhang,Xin Li et al.
Min Hu et al.
Growing evidence suggests that epithelial-mesenchymal transition (EMT) and its regulator mitogen-activated protein kinase (MAPK) contribute to endometria-related reproductive disorders. However, the regulation of EMT and MAPK signalling com...
Effect of sphingosine-1-phosphate on activation of dormant follicles in murine and human ovarian tissue [0.03%]
鞘氨醇-1-磷酸对小鼠和人类卵巢组织中静止卵泡激活的影响
Susanne Elisabeth Pors,Lilja Harðardóttir,Hanna Ørnes Olesen et al.
Susanne Elisabeth Pors et al.
In vitro activation of resting ovarian follicles, with the use of mechanical stress and/or pharmacological compounds, is an emerging and novel approach for infertility treatment. The aim of this study was to assess the sphingolipid, sphingo...
Abnormal Cullin1 neddylation-mediated p21 accumulation participates in the pathogenesis of recurrent spontaneous abortion by regulating trophoblast cell proliferation and differentiation [0.03%]
异常的Cul1泛素化介导的p21积累通过调节滋养细胞增殖和分化参与复发性流产发病机制
Xiaohe Sun,Xiaomei Tong,Yanqing Hao et al.
Xiaohe Sun et al.
The study explores the role of neddylation in early trophoblast development and its alteration during the pathogenesis of recurrent spontaneous abortion (RSA). Immunofluorescence and western blot were conducted to evaluate the expression pa...
C-C motif chemokine receptor 2 as a novel intermediate in the ovulatory cascade [0.03%]
C-趋化因子动机受体2是排卵级联反应中的一个新中间体
J P Jaworski,M Urrutia,E Dascal et al.
J P Jaworski et al.
Expression of immune function genes within follicle cells has been reported in ovaries from many species. Recent work from our laboratory showed a direct effect of the monocyte chemoattractant protein 1/C-C motif chemokine receptor 2 system...
Establishment of an in vitro placental barrier model cultured under physiologically relevant oxygen levels [0.03%]
基于生理相关氧浓度的体外胎盘屏障模型的建立
Michael K Wong,Edward W Li,Mohamed Adam et al.
Michael K Wong et al.
The human placental barrier facilitates many key functions during pregnancy, most notably the exchange of all substances between the mother and fetus. However, preclinical models of the placental barrier often lacked the multiple cell layer...
Prednisolone in early pregnancy inhibits regulatory T cell generation and alters fetal and placental development in mice [0.03%]
孕早期使用 prednisolone 抑制小鼠的调节性 T 细胞生成并改变胎儿和胎盘的发育
Tom Ec Kieffer,Peck Y Chin,Ella S Green et al.
Tom Ec Kieffer et al.
Corticosteroids have been utilised in the assisted reproduction setting with the expectation of suppressing aberrant immune activation and improving fertility in women. However, the effects of corticosteroids on fertility, and on pregnancy ...
Zinc exocytosis is sensitive to myosin light chain kinase inhibition in mouse and human eggs [0.03%]
锌颗粒释放受肌球蛋白轻链激酶抑制的影响——小鼠及人卵的例子
Hoi Chang Lee,Maxwell E Edmonds,Francesca E Duncan et al.
Hoi Chang Lee et al.
Zinc dynamics are essential for oocyte meiotic maturation, egg activation, and preimplantation embryo development. During fertilisation and egg activation, the egg releases billions of zinc atoms (Zn2+) in an exocytotic event termed the 'zi...
Interleukin-37b inhibits the growth of murine endometriosis-like lesions by regulating proliferation, invasion, angiogenesis and inflammation [0.03%]
白细胞介素37b通过调节增殖、侵袭、血管生成和炎症抑制小鼠子宫内膜异位症样病变的生长
Yongpei He,Ting Xiong,Fang Guo et al.
Yongpei He et al.
Endometriosis is a gynecological disease with abnormal expression of interleukin (IL)-37 which can suppress inflammation and the immune system. Here we investigated the role of the IL-37b splice variant in endometriosis in vivo and in vitro...
Using miRNAs as diagnostic biomarkers for male infertility: opportunities and challenges [0.03%]
miRNA作为男性不育诊断标志物的应用及挑战
A Vashisht,G K Gahlay
A Vashisht
The non-coding genome has been extensively studied for its role in human development and diseases. MicroRNAs (miRNAs) are small non-coding RNAs, which can regulate the expression of hundreds of genes at the post-transcriptional level. There...
Metabolic profile of in vitro derived human embryos is not affected by the mode of fertilization [0.03%]
体外人类胚胎的代谢谱不受受精方式的影响
Christine Leary,Roger G Sturmey
Christine Leary
The pattern of metabolism by early embryos in vitro has been linked to a range of phenotypes, including viability. However, the extent to which metabolic function of embryos is modified by specific methods used during ART has yet to be full...
Comparative Study
Molecular human reproduction. 2020 Apr 24;26(4):277-287. DOI:10.1093/molehr/gaaa015 2020