Mimicking the temperature gradient between the sow's oviduct and uterus improves in vitro embryo culture output [0.03%]
模拟母猪输卵管和子宫内的温度梯度可提高体外培养胚胎的品质与发育潜能
S García-Martínez,R Latorre,M A Sánchez-Hurtado et al.
S García-Martínez et al.
This work was designed to determine temperature conditions within the reproductive tract of the female pig and study their impact on ARTs. Temperatures were recorded using a laparo-endoscopic single-site surgery assisted approach and a mini...
A tale of two cell-fates: role of the Hippo signaling pathway and transcription factors in early lineage formation in mouse preimplantation embryos [0.03%]
小鼠着床前胚胎早期谱系形成过程中Hippo信号通路与转录因子的作用机制及表观遗传调控研究
Challis Karasek,Mohamed Ashry,Chad S Driscoll et al.
Challis Karasek et al.
In mammals, the first cell-fate decision occurs during preimplantation embryo development when the inner cell mass (ICM) and trophectoderm (TE) lineages are established. The ICM develops into the embryo proper, while the TE lineage forms th...
The alarmin interleukin-1α causes preterm birth through the NLRP3 inflammasome [0.03%]
警报素白介素-1α通过NLRP3炎性小体引起早产
K Motomura,R Romero,V Garcia-Flores et al.
K Motomura et al.
Sterile intra-amniotic inflammation is a clinical condition frequently observed in women with preterm labor and birth, the leading cause of neonatal morbidity and mortality worldwide. Growing evidence suggests that alarmins found in amnioti...
Vitrification-induced activation of lysosomal cathepsin B perturbs spindle assembly checkpoint function in mouse oocytes [0.03%]
玻璃化冷冻通过激活小鼠卵母细胞溶酶体Cathepsin B功能紊乱影响纺锤体组装检测点功能
Ahmed Z Balboula,Karen Schindler,Tomoya Kotani et al.
Ahmed Z Balboula et al.
As the age of child-bearing increases and correlates with infertility, cryopreservation of female gametes is becoming common-place in ART. However, the developmental competence of vitrified oocytes has remained low. The underlying mechanism...
Premature ovarian insufficiency in the XO female mouse on the C57BL/6J genetic background [0.03%]
嵌合体小鼠遗传背景影响卵巢早衰表型
B Vaz,F El Mansouri,X Liu et al.
B Vaz et al.
In humans, all but 1% of monosomy 45.X embryos die in utero and those who reach term suffer from congenital abnormalities and infertility termed Turner's syndrome (TS). By contrast, XO female mice on various genetic backgrounds show much mi...
STAG3 homozygous missense variant causes primary ovarian insufficiency and male non-obstructive azoospermia [0.03%]
STAG3同型错义变异导致卵巢早期衰竭和男性非梗阻性无精子症
Sylvie Jaillard,Kenneth McElreavy,Gorjana Robevska et al.
Sylvie Jaillard et al.
Infertility, a global problem affecting up to 15% of couples, can have varied causes ranging from natural ageing to the pathological development or function of the reproductive organs. One form of female infertility is premature ovarian ins...
Effects of vitrification and the superovulated environment on placental function and fetal growth in an IVF mouse model [0.03%]
玻璃化冷冻及超排卵环境对小鼠体外受精模型胎盘功能和胎儿发育的影响
C Roeca,E Silva,C Barentsen et al.
C Roeca et al.
In studies of human IVF, as compared to frozen embryo transfer (ET), fresh ET is associated with smaller infants and higher risk of small for gestational age infants. Recent observations suggest that ET using vitrified embryos is associated...
Perinatal exposure to high dietary advanced glycation end products affects the reproductive system in female offspring in mice [0.03%]
孕期高膳食晚期糖基化终产物暴露影响小鼠雌性后代生殖系统
Zaher Merhi,Xiu Quan Du,Maureen J Charron
Zaher Merhi
Maternal nutrition and the intrauterine environment are important in determining susceptibility to reproductive and metabolic disturbances. Advanced glycation end products (AGEs) are widely consumed in Western diet. The purpose of this stud...
Functional changes in decidual mesenchymal stem/stromal cells are associated with spontaneous onset of labour [0.03%]
蜕膜间充质干细胞/基质细胞的功能变化与自发性分娩相关
Joan C Wijaya,Ramin Khanabdali,Harry M Georgiou et al.
Joan C Wijaya et al.
Ageing and parturition share common pathways, but their relationship remains poorly understood. Decidual cells undergo ageing as parturition approaches term, and these age-related changes may trigger labour. Mesenchymal stem/stromal cells (...
BHLHE40 plays a pathological role in pre-eclampsia through upregulating SNX16 by transcriptional inhibition of miR-196a-5p [0.03%]
BHLHE40通过转录抑制miR-196a-5p来上调SNX16在先兆子痫的病理作用中扮演角色
Chunmei Mi,Bin Ye,Zhou Gao et al.
Chunmei Mi et al.
Pre-eclampsia (PE), which results from abnormal placentation, is a primary cause of maternal and neonatal morbidity and mortality. However, the causes of abnormal development of the placenta remain poorly understood. BHLHE40 is a transcript...