Roles of chromosomal and gonadal sex in the fetal and placental responses to maternal food restriction in mice [0.03%]
小鼠母体营养限制对胎儿和胎盘性别二态反应的遗传学机制研究
Jess C Hercus,Daniel Alejandro Salcedo Rubio,Maria Elisa Osorio Nieto et al.
Jess C Hercus et al.
It is hypothesized that male fetuses are more vulnerable to in utero insults than females due to different growth strategies, and that the placenta contributes to these sex differences. We examined sex differences in the fetal and placental...
OTUD1 inhibits endometriosis fibrosis by deubiquitinating MADH7 [0.03%]
OTUD1通过去泛素化MADH7抑制子宫内膜异位症纤维化
Xiangyu Chang,Yanqin Zhang,Mengqi Deng et al.
Xiangyu Chang et al.
Fibrosis constitutes the principal pathophysiological mediator of pain and infertility manifestations in endometriosis, and the inhibitory factor of TGF-β pathway, MADH7, makes a vital impact on the progression of fibrosis. Ovarian tumour ...
Effects of chronic particulate matter exposure on endometriosis-associated signaling pathways and disease progression [0.03%]
慢性颗粒物暴露对子宫内膜异位症相关信号通路和疾病进展的影响
Gee Soo Jung,Jae Hoon Lee,Min Jung Lee et al.
Gee Soo Jung et al.
Exposure to PM2.5 (particulate matter
Correction to: Understanding the heterogeneity of natural killer cells at the maternal-fetal interface: implications for pregnancy health and disease [0.03%]
Correction to:理解自然杀伤细胞在母胎界面的异质性：对妊娠健康和疾病的启示
Published Erratum
Molecular human reproduction. 2025 Apr 3;31(2):gaaf010. DOI:10.1093/molehr/gaaf010 2025
Exploring and validating the marmoset as a primate model for chromosomal instability in early development [0.03%]
早期发育过程中以染色体不稳定为特征的非人灵长类模型狨猴的研究与验证
Andrew Cearlock,Hubert Mysliwiec,Margarita Agarsheva et al.
Andrew Cearlock et al.
Aneuploidy in embryos poses a major barrier to successful human reproduction, contributing to nearly 50% of early miscarriages. Despite its high prevalence in human embryos, the molecular mechanisms regulating aneuploid cell fate during dev...
Protein-targeting reverse genetic approaches: the future of oocyte and preimplantation embryo research [0.03%]
蛋白质定位的反向遗传方法：卵母细胞和着床前胚胎研究的未来
Nicole J Camlin
Nicole J Camlin
Reverse genetic approaches are the standard in molecular biology to determine a protein's function. Traditionally, nucleic acid targeting via gene knockout (DNA) and knockdown (RNA) has been the method of choice to remove proteins-of-intere...
Human platelet-rich plasma promotes primordial follicle activation via the PI3K/akt signaling pathway [0.03%]
人富血小板血浆通过PI3K/akt信号通路促进原始卵泡激活
Yashuang Weng,Wenbo Zhang,Fan Qu et al.
Yashuang Weng et al.
The activation of dormant primordial follicles is a promising method to improve the fertility of premature ovarian insufficiency (POI) patients. Many experiments from both human and animal studies suggest that human platelet-rich plasma (hP...
A comprehensive study of the sperm head defects in MMAF condition and their impact on embryo development in mice [0.03%]
MMAF条件下小鼠精子头部缺陷的综合研究及其对胚胎发育的影响
Jana Muroňová,Emeline Lambert,Chanyuth Thamwan et al.
Jana Muroňová et al.
Among rare cases of teratozoospermia, MMAF (multiple morphological abnormalities of the flagellum) syndrome is a complex genetic disorder involving at least 70 different genes. As the name suggests, patients with MMAF syndrome produce sperm...
Bioenergetics of human spermatozoa in patients with testicular germ cell tumours [0.03%]
患有睾丸生殖细胞瘤患者的精子生物能量学研究
Ondrej Simonik,Barbora Bryndova,Vishma Pratap Sur et al.
Ondrej Simonik et al.
In patients with testicular germ cell tumours (TGCT), sperm cryopreservation prior to anti-cancer treatment represents the main fertility preservation approach. However, it is associated with low sperm recovery rate after thawing. Since spe...
MCP-1 promotes ILK phosphorylation at Ser246 during endometriosis development and affects the pregnancy outcome [0.03%]
在子宫内膜异位症发展中MCP-1促进ILK在Ser246处的磷酸化并影响妊娠结局
Upendra Kumar Soni,Rupal Tripathi,Pushplata Sankhwar et al.
Upendra Kumar Soni et al.
In women with endometriosis, monocyte chemoattractant protein 1 (MCP-1) or chemokine (C-C motif) ligand 2 (CCL2) is elevated in serum, peritoneal fluid, and endometriotic lesions, though its exact role in endometriosis is still unknown. The...