Discordant effects of maternal age on the human MII oocyte transcriptome [0.03%]
母龄对人类MII卵母细胞转录组的不一致效应
Xiaorui Zhang,Jiao Yang,Wenting Yang et al.
Xiaorui Zhang et al.
While advanced maternal age is associated with significant changes in oocyte gene expression, these are not global changes but limited to a fraction of the transcriptome. However, there is little consensus on the specific genes affected, an...
Correction to: WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Homologous): homologous rodent models [0.03%]
纠正：WERF子宫内膜异位症表型和生物库协调项目在子宫内膜异位症研究中的同源动物模型（EPHect-EM-同种移植物） проект по гармонизации фенотипа и биобанковирования при эндометриозе (WERF EPHect-EM) для экспериментальных моделей эндометриоза: модели с однородными аллографами у крыс и мышей
Published Erratum
Molecular human reproduction. 2025 Jul 3;31(3):gaaf036. DOI:10.1093/molehr/gaaf036 2025
Correction to: WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Heterologous): heterologous rodent models [0.03%]
对WERF子宫内膜异位症表型和生物库协调项目（EPHect-EM-异种移植）用于异种子宫内膜异位症实验模型的修正：异种啮齿动物模型
Published Erratum
Molecular human reproduction. 2025 Jul 3;31(3):gaaf033. DOI:10.1093/molehr/gaaf033 2025
WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Heterologous): heterologous rodent models [0.03%]
外异体动物模型的子宫内膜异位症表型和生物信息库协调项目（EPHect-EM-Heterologous）：异种啮齿类实验模型
M Louise Hull,Raul Gomez,Warren B Nothnick et al.
M Louise Hull et al.
Endometriosis, defined as the growth of endometrial-like tissues outside the uterus, is a common disease among women. Numerous in vivo rodent models of endometriosis have been developed to explore multiple aspects of this poorly understood ...
HOXC4 promotes proliferation of endometriotic stromal cells via the SLIT2-ROBO1 axis [0.03%]
HOXC4通过SLIT2-ROBO1轴促进子宫内膜异位病灶成纤维细胞的增殖
Yuqi Yang,Bo Yin,Cenyu Li et al.
Yuqi Yang et al.
Current interventions for endometriosis mainly involve hormone therapies but have limited efficacy and unacceptable side effects, due to the lack of selectivity to distinguish between endometriosis and endometrial tissues. Elucidating the m...
Down-regulation of IGFBP2 mediates endometrial epithelial cells senescence in thin endometrium [0.03%]
IGFBP2低表达介导薄型子宫内膜上皮细胞衰老
Zihan Zhou,Zhenhua Zhou,Chunying Ye et al.
Zihan Zhou et al.
Thin endometrium (TE) is generally recognized as a contributing factor to reduced pregnancy rates and adverse perinatal outcomes, yet the pathogenesis of the disease remains elusive. We conducted an analysis and validation of the single-cel...
McKenna J Crossen,Shuai Jia,Joan S Jorgensen et al.
McKenna J Crossen et al.
The Wolffian duct (WD) is the embryonic primordium that gives rise to the epididymis, vas deferens and seminal vesicle. The androgen action in the mesenchyme is the predominant driver for fetal WD maintenance, which is essential for male fe...
Fertility is compromised after oocyte-specific deletion of microtubule severing protein katanin A1 [0.03%]
卵细胞特异性删除微管切割蛋白katanin A1会损害受孕率
Wai Shan Yuen,Qing-Hua Zhang,Monique Dunstan et al.
Wai Shan Yuen et al.
Katanins are microtubule severing enzymes that play roles in diverse cell functions including meiotic and mitotic spindle formation. To address the role of Katanin p60 isozymes in mammalian oocytes, we have used the ZP3-CreLox approach to s...
Identification of transcription factors that regulate placental sFLT1 expression [0.03%]
鉴定调控胎盘sflt1表达的转录因子
Qing Yong,Carin van der Keur,Jacqueline D H Anholts et al.
Qing Yong et al.
Increased sFLT1 levels have been associated with preeclampsia, chronic kidney diseases, and kidney transplant rejection. However, lower levels of sFLT1 exhibit beneficial properties in various processes, such as organization of the actin cy...
WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Heterologous): heterologous rodent models [0.03%]
外异体动物模型的子宫内膜异位症表型和生物库协调项目（EPHect-EM-Heterologous）：异种啮齿类动物模型
M Louise Hull,Raul Gomez,Warren B Nothnick et al.
M Louise Hull et al.
Endometriosis, defined as the growth of endometrial-like tissues outside the uterus, is a common disease among women. Numerous in vivo rodent models of endometriosis have been developed to explore multiple aspects of this poorly understood ...