Developing anti-Müllerian hormone as an ovarian reserve biomarker [0.03%]
抗müller管激素作为卵巢储备生物标志物的研究进展
Bart C J M Fauser
Bart C J M Fauser
The first anti-Müllerian hormone (AMH) radioimmunoassay became available for clinical use in the early 2000s. This MHR Legacy Series review discusses key contributions from our own group towards establishing AMH as a robust ovarian reserve...
Assessment and Supplementation of Antioxidant Amines in Male Infertility-Are We Approaching Clinical Implementation? [0.03%]
评估和补充抗氧化胺在男性不育中的作用-我们是否即将进入临床实施阶段？
Coraline Lugart,Nikaïa Smith,Ingrid Plotton et al.
Coraline Lugart et al.
Male infertility remains unexplained in a substantial proportion of cases, despite extensive clinical and biological investigations. Oxidative stress has emerged as a central pathophysiological mechanism underlying impaired sperm function, ...
Cell-penetrating alpha-synuclein accelerates the late stages of the acrosome reaction in human sperm [0.03%]
细胞穿透型α-突触核蛋白加速人类精子顶体反应晚期阶段的发生
Micaela Vanina Buzzatto,Jorge Ernesto Ibáñez,Claudia Nora Tomes
Micaela Vanina Buzzatto
Secretory vesicles discharge their contents into the extracellular space through fusion pores; the behaviour of these structures regulates release kinetics. In sperm, acrosomal contents are released after the expansion of multiple pores for...
The journey of maternal platelets through the utero-placental circulation: Routes, Interactions and Physiological Implications [0.03%]
母体血小板在子宫胎盘循环中的旅程：路径、相互作用和生理意义
Désirée Forstner,Martin Gauster,Berthold Huppertz et al.
Désirée Forstner et al.
Maternal platelets fulfil an exceptional and multifaceted plethora of roles during pregnancy, extending far beyond their traditional function in hemostasis. Increasing evidence suggests that platelets participate in placental development, i...
Activation of the lysophosphatidic acid-Lpar3 axis contributes to platelet rich plasma-induced decidualization [0.03%]
肥大细胞通过lysophosphatidic acid-Lpar3轴活化促进富血小板血浆诱导的子宫内膜蜕膜化
Tetsuaki Kaku,Shizu Aikawa,Kuniyuki Kano et al.
Tetsuaki Kaku et al.
Despite significant advancements in ARTs, nearly 70% of embryo transfers fail, with implantation failure being the primary cause. Proper embryo implantation requires coordinated communication between the blastocyst and a receptive endometri...
Hypoxia-induced miR-21-5p promotes autophagy by downregulating CDC25A in endometriosis [0.03%]
缺氧通过下调CDC25A诱导miR-21-5p促进子宫内膜异位症进程中的自噬反应
Huan-Tzu Hou,Ya-Chuan Tsai,Shih-Chieh Lin et al.
Huan-Tzu Hou et al.
Endometriosis is a common gynecological disorder affecting women of reproductive age, often leading to chronic pain, reduced quality of life, and infertility. It is characterized by ectopic endometrial growth within a hypoxic peritoneal env...
Exogenous Putrescine Supplementation Improves Cyclophosphamide-induced Premature Ovarian Insufficiency in Mice [0.03%]
外源补充尸胺改善环磷酰胺致小鼠卵巢早衰的效应及机制研究
Chenxi Zhao,Cong Xu,Qian Zhang et al.
Chenxi Zhao et al.
The incidence of premature ovarian insufficiency (POI) is gradually increasing, and currently no clinical treatments are available to restore ovarian function in POI patients, which severely affects the physical and mental health of young w...
Cyclic Stretch Activates Endometrial Stromal Cells to Enhance Migration and Invasion via Mechanosensitive p38 MAPK and F-actin in vitro [0.03%]
体外周期拉伸通过机械敏感p38MAPK和F肌动蛋白活化子宫内膜间质细胞从而增强其迁移和侵袭能力
Yu-Yin Liu,Yu-Hang Zhang,Chu-Jun Jiang et al.
Yu-Yin Liu et al.
Adenomyosis (AM) is traditionally explained by biochemical dysregulation at the endometrial-myometrial interface, leading to passive displacement of endometrial stromal cells (ESCs). However, the uterus is a highly mechanosensitive organ. A...
What we could not have known: ovarian cycles, follicle development, and the signature of life [0.03%]
我们不知道的是：卵巢周期、卵泡发育和生命的痕迹
Teresa K Woodruff
Teresa K Woodruff
Reproductive science is a discipline of generation and for generations. Our work has focused on the signals that drive reproductive cycles at the organismal and the organ level. The principal endocrine signals of male and female reproductiv...
The Legacy Series: shining light on our origins to inform the future of reproductive science and medicine [0.03%]
传承之路——照亮生殖科学和医学的过去与未来
Francesca E Duncan
Francesca E Duncan