Embryonic fatty acid metabolism in diabetic pregnancy: the difference between embryoblasts and trophoblasts [0.03%]
糖尿病孕妇胚胎的脂肪酸代谢：胚芽与滋养层细胞之间的差异
Maria Schindler,Dirk Dannenberger,Gerd Nuernberg et al.
Maria Schindler et al.
During the first days of development the preimplantation embryo is supplied with nutrients from the surrounding milieu. Maternal diabetes mellitus affects the uterine microenvironment, leading to a metabolic adaptation processes in the embr...
Revisiting the action of steroids and triterpenoids on the human sperm Ca2+ channel CatSper [0.03%]
甾体和三萜类化合物对人类精子Ca2+通道CatSper的作用新探
Anders Rehfeld
Anders Rehfeld
The sperm-specific Ca2+ channel CatSper (cation channel of sperm) is vital for male fertility. Contradictory findings have been published on the regulation of human CatSper by the endogenous steroids estradiol, testosterone and hydrocortiso...
Palmitic acid induces inflammation in placental trophoblasts and impairs their migration toward smooth muscle cells through plasminogen activator inhibitor-1 [0.03%]
软脂酸通过纤溶酶原激活物抑制剂-1诱导胎盘滋养层的炎症并损害其向平滑肌细胞迁移
Amanda M Rampersaud,Caroline E Dunk,Stephen J Lye et al.
Amanda M Rampersaud et al.
A critical component of early human placental development includes migration of extravillous trophoblasts (EVTs) into the decidua. EVTs migrate toward and displace vascular smooth muscle cells (SMCs) surrounding several uterine structures, ...
Comparative study of preimplantation development following distinct assisted oocyte activation protocols in a PLC-zeta knockout mouse model [0.03%]
PLC-zeta基因敲除小鼠模型中不同辅助卵母细胞激活方案对着床前发育影响的比较研究
M Ferrer-Buitrago,L Tilleman,V Thys et al.
M Ferrer-Buitrago et al.
Mammalian fertilization encompasses a series of Ca2+ oscillations initiated by the sperm factor phospholipase C zeta (PLCζ). Some studies have shown that altering the Ca2+ oscillatory regime at fertilization affects preimplantation blastoc...
Comparative Study
Molecular human reproduction. 2020 Nov 1;26(11):801-815. DOI:10.1093/molehr/gaaa060 2020
Decorin production by the human decidua: role in decidual cell maturation [0.03%]
人蜕膜中 Decorin 的生成：在蜕膜细胞成熟中的作用
C D Halari,P Nandi,M J Jeyarajah et al.
C D Halari et al.
Decidualization involves the proliferation and differentiation of fibroblast-like endometrial stromal cells into epithelioid-shaped and secretory 'decidual' cells in response to steroid hormones. Human decidual cells produce insulin-like gr...
High-throughput sequencing reveals landscapes of female germ cell development [0.03%]
高通量测序揭示雌性生殖细胞发育的景观
Zheng-Hui Zhao,Heide Schatten,Qing-Yuan Sun
Zheng-Hui Zhao
Female germ cell development is a highly complex process that includes meiosis initiation, oocyte growth recruitment, oocyte meiosis retardation and resumption and final meiotic maturation. A series of coordinated molecular signaling factor...
The molecular mechanisms that underlie fragile X-associated premature ovarian insufficiency: is it RNA or protein based? [0.03%]
导致脆性X综合征相关卵巢早衰的分子机制：是RNA还是蛋白质？
Roseanne Rosario,Richard Anderson
Roseanne Rosario
The FMR1 gene contains a polymorphic CGG trinucleotide sequence within its 5' untranslated region. More than 200 CGG repeats (termed a full mutation) underlie the severe neurodevelopmental condition fragile X syndrome, while repeat lengths ...
Ionomycin-induced mouse oocyte activation can disrupt preimplantation embryo development through increased reactive oxygen species reaction and DNA damage [0.03%]
离子霉素诱发的小鼠卵子去极化通过增加活性氧反应和DNA损伤破坏胚胎植入前发育
Chen Chen,Tingye Sun,Mingru Yin et al.
Chen Chen et al.
Oocyte activation induced by calcium oscillations is an important process in normal fertilization and subsequent embryogenesis. In the clinical-assisted reproduction, artificial oocyte activation (AOA) is an effective method to improve the ...
Pubertal down-regulation of Tetraspanin 8 in testicular Sertoli cells is crucial for male fertility [0.03%]
四膜素蛋白8在睾丸支持细胞中的青春期内向调节对雄性生育力至关重要
Bhola Shankar Pradhan,Indrashis Bhattacharya,Rajesh Sarkar et al.
Bhola Shankar Pradhan et al.
The alarming decline in sperm count has become a global concern in the recent decades. The division and differentiation of male germ cells (Gc) into sperm are governed by Sertoli cells (Sc) upon their functional maturation during puberty. H...
Analysis of accessible chromatin landscape in the inner cell mass and trophectoderm of human blastocysts [0.03%]
人blastosphere中inner cell mass和trophectoderm的可访问染色质景观分析
Min Yang,Xin Tao,Shiny Titus et al.
Min Yang et al.
Early embryonic development is characterized by drastic changes in chromatin structure that affects the accessibility of the chromatin. In human, the chromosome reorganization and its involvement in the first linage segregation are poorly c...