4-Hydroxyestradiol improves mouse embryo quality, epidermal growth factor-binding capability in vitro and implantation rates [0.03%]
4-羟基雌二醇能提高小鼠胚胎质量、体外表皮生长因子结合能力及着床率
Nuria Hernández,Marta López-Morató,Mario J Perianes et al.
Nuria Hernández et al.
Embryo implantation in the uterus is a critical step to achieve success following ART. Despite favorable uterine conditions, a great number of good quality embryos fail to implant, often for reasons that are unknown. Hence, improving the im...
A combination of growth factors and cytokines alter preimplantation mouse embryo development, foetal development and gene expression profiles [0.03%]
生长因子和细胞因子的结合改变了小鼠胚胎植入前发育、胎儿发育和基因表达谱型
Kathryn H Gurner,Thi T Truong,Alexandra J Harvey et al.
Kathryn H Gurner et al.
Within the maternal tract, the preimplantation embryo is exposed to an array of growth factors (GFs) and cytokines, most of which are absent from culture media used in clinical IVF. Whilst the addition of individual GFs and cytokines to emb...
Mice born to females with oocyte-specific deletion of mitofusin 2 have increased weight gain and impaired glucose homeostasis [0.03%]
卵母细胞特异性删除线粒体融合蛋白2的小鼠体重增加且糖代谢受损
Bruna M Garcia,Thiago S Machado,Karen F Carvalho et al.
Bruna M Garcia et al.
Offspring born to obese and diabetic mothers are prone to metabolic diseases, a phenotype that has been linked to mitochondrial dysfunction and endoplasmic reticulum (ER) stress in oocytes. In addition, metabolic diseases impact the archite...
Two human menopausal gonadotrophin (hMG) preparations display different early signaling in vitro [0.03%]
两种人绝经期促性腺激素（hMG）制剂在体外显示出不同的早期信号反应
Livio Casarini,Laura Riccetti,Elia Paradiso et al.
Livio Casarini et al.
Commercial hMG drugs are marketed for the treatment of infertility and consist of highly purified hormones acting on receptors expressed in target gonadal cells. Menopur® and Meriofert® are combined preparation of FSH and hCG and are comp...
A mouse model reveals the events and underlying regulatory signals during the gonadotrophin-dependent phase of follicle development [0.03%]
一个老鼠模型揭示了在促性腺激素依赖阶段的卵泡发育过程中发生的事件和潜在的调节信号
Yingjun Chen,Xiaodong Wang,Chan Yang et al.
Yingjun Chen et al.
During folliculogenesis, the gonadotrophin (GTH)-dependent phase begins at the small antral follicle stage and ends with Graafian follicles. In this study, pregnant mare's serum GTH was used to induce GTH-dependent folliculogenesis in mice,...
Extracellular vesicles miRNA-21: a potential therapeutic tool in premature ovarian dysfunction [0.03%]
外泌体miRNA-21：早发性卵巢功能不全的一种潜在治疗工具
Eman Thabet,Alaaeldin Yusuf,Doaa A Abdelmonsif et al.
Eman Thabet et al.
Chemotherapy induces an irreversible premature ovarian dysfunction (POD). Amniotic fluid mesenchymal stem cells (AFMSCs) can rescue fertility; however, the notion that stem cells can rejuvenate follicles is highly controversial due to the p...
A novel xeno-organoid approach: exploring the crosstalk between human iPSC-derived PGC-like and rat testicular cells [0.03%]
一种新型的异种类器官方法：人iPSC来源的PGC类似物与大鼠睾丸细胞之间的相互作用探索
E M Mall,N Rotte,J Yoon et al.
E M Mall et al.
Specification of germ cell-like cells from induced pluripotent stem cells has become a clinically relevant tool for research. Research on initial embryonic processes is often limited by the access to foetal tissue, and in humans, the molecu...
Unscrambling the oocyte and the egg: clarifying terminology of the female gamete in mammals [0.03%]
解开卵母细胞和卵子的混淆：澄清哺乳动物雌性配子的术语
Francesca E Duncan,Karen Schindler,Richard M Schultz et al.
Francesca E Duncan et al.
Most reproductive biologists who study female gametes will agree with the 16th century anatomist William Harvey's doctrine: 'Ex Ovo Omnia'. This phrase, which literally translates to 'everything from the egg', recognizes the centrality of t...
Annexin A2 acts as an adherent molecule under the regulation of steroids during embryo implantation [0.03%]
Annexin A2在类固醇调节下作为分子在胚胎着床过程中起到粘附作用
Bing Wang,Yan Shao
Bing Wang
We previously showed that annexin A2 (Axna2) was transiently expressed at the embryo-uterine luminal epithelium interface during the window of implantation and was involved in mouse embryo implantation. At the same time, Axna2 was reported ...
Sex-specific epigenetic profile of inner cell mass of mice conceived in vivo or by IVF [0.03%]
体内受精或体外受精小鼠的内细胞团的性别特异性表观遗传谱
Elena Ruggeri,Saúl Lira-Albarrán,Edward J Grow et al.
Elena Ruggeri et al.
The preimplantation stage of development is exquisitely sensitive to environmental stresses, and changes occurring during this developmental phase may have long-term health effects. Animal studies indicate that IVF offspring display metabol...
Comparative Study
Molecular human reproduction. 2020 Nov 1;26(11):866-878. DOI:10.1093/molehr/gaaa064 2020