Use of selective PGE2 receptor antagonists on human endometriotic stromal cells and peritoneal macrophages [0.03%]
选择性PGE2受体拮抗剂对人子宫内膜间质细胞和腹膜巨噬细胞的作用
Tomoko Makabe,Kaori Koga,Hiroshi Nagabukuro et al.
Tomoko Makabe et al.
Non-hormonal therapeutic strategies for endometriosis are needed. The aim of this study was to characterize the effects of prostaglandin (PG)E2 receptor inhibitors to explore their potential as novel therapeutic strategies for endometriosis...
Oligoasthenoteratospermia and sperm tail bending in PPP4C-deficient mice [0.03%]
PPP4C缺陷小鼠的精子寡弱畸精症和鞭毛弯曲现象
F Han,M Z Dong,W L Lei et al.
F Han et al.
Protein phosphatase 4 (PPP4) is a protein phosphatase that, although highly expressed in the testis, currently has an unclear physiological role in this tissue. Here, we show that deletion of PPP4 catalytic subunit gene Ppp4c in the mouse c...
Oligoasthenoteratospermia and sperm tail bending in PPP4C-deficient mice [0.03%]
PPP4C缺陷小鼠的精子寡弱畸精症和精子尾部弯曲现象
F Han,M Z Dong,W L Lei et al.
F Han et al.
Protein phosphatase 4 (PPP4) is a protein phosphatase that, although highly expressed in the testis, currently has an unclear physiological role in this tissue. Here, we show that deletion of PPP4 catalytic subunit gene Ppp4c in the mouse c...
Current mechanisms of primordial follicle activation and new strategies for fertility preservation [0.03%]
卵泡激活机制与生育力保存的新策略研究进展
Yan Zhang,Xiaomei Zhou,Ye Zhu et al.
Yan Zhang et al.
Premature ovarian insufficiency (POI) is characterized by symptoms caused by ovarian dysfunction in patients aged
Dexamethasone-induced intrauterine growth restriction modulates expression of placental vascular growth factors and fetal and placental growth [0.03%]
糖皮质激素致宫内生长受限影响胎盘血管生成因子及胎儿、胎盘生长
A Arias,J A Schander,M V Bariani et al.
A Arias et al.
Prenatal exposure to glucocorticoids (GC) is a central topic of interest in medicine since GCs are essential for the maturation of fetal organs and intrauterine growth. Synthetic glucocorticoids, which are used in obstetric practice, exert ...
Heparin fragments induce cervical inflammation by recruiting immune cells through Toll-like receptor 4 in nonpregnant mice [0.03%]
肝素片段通过 toll 样受体 4 招募免疫细胞诱导非妊娠小鼠宫颈炎症
Anna Åkerud,Jakob Axelsson,Manisha Yadav et al.
Anna Åkerud et al.
Inflammation is a hallmark in the human cervix remodelling. A possible candidate inducing the inflammatory driven ripening of the cervix is the matrix component heparan sulphate, which has been shown to be elevated in late pregnancy in the ...
Nuclear factor-kappa B signaling in endometriotic stromal cells is not inhibited by progesterone owing to an aberrant endoplasmic reticulum stress response: a possible role for an altered inflammatory process in endometriosis [0.03%]
核因子κB在子宫内膜异位症成纤维细胞中的活化与异常的内质网应激反应相关：子宫内膜异位症中可能存在一种改变的炎症过程
JongYeob Choi,MinWha Jo,EunYoung Lee et al.
JongYeob Choi et al.
Endoplasmic reticulum (ER) stress serves as a key modulator of the inflammatory response by controlling nuclear factor-kappaB (NF-κB) signaling. Previous studies from our laboratory have reported an abnormal induction of ER stress linked t...
Induction of aryl hydrocarbon receptor in granulosa cells by endoplasmic reticulum stress contributes to pathology of polycystic ovary syndrome [0.03%]
颗粒细胞内质网应激诱导芳烃受体参与多囊卵巢综合征病理过程
Chisato Kunitomi,Miyuki Harada,Akari Kusamoto et al.
Chisato Kunitomi et al.
Recent studies have uncovered the critical role of aryl hydrocarbon receptor (AHR) in various diseases, including obesity and cancer progression, independent of its previously identified role as a receptor for endocrine-disrupting chemicals...
Aspirin reduces sFlt-1-mediated apoptosis of trophoblast cells in preeclampsia [0.03%]
阿司匹林通过减少sFlt-1介导的滋养细胞凋亡治疗子痫前期
Qing Zuo,Yanfeng Zou,Shiyun Huang et al.
Qing Zuo et al.
Preeclampsia (PE) is a hypertensive disorder that occurs during pregnancy. Low-dose aspirin is used to reduce the occurrence of early-onset PE; however, the mechanisms are not clear. The aim of this study was to reveal the underlying mechan...
FMR1 expression in human granulosa cells and variable ovarian response: control by epigenetic mechanisms [0.03%]
人类颗粒细胞中FMR1表达和卵巢反应的多变性：表观遗传机制的作用控制
Julia Rehnitz,Berthe Youness,Xuan Phuoc Nguyen et al.
Julia Rehnitz et al.
In humans, FMR1 (fragile X mental retardation 1) is strongly expressed in granulosa cells (GCs) of the female germline and apparently controls efficiency of folliculogenesis. Major control mechanism(s) of the gene transcription rate seem to...