The COP9 signalosome subunit 3 is necessary for early embryo survival by way of a stable protein deposit in mouse oocytes [0.03%]
COP9信号体亚基3通过小鼠卵母细胞中的稳定蛋白质沉积在早期胚胎存活中是必要的
Steffen Israel,Hannes C A Drexler,Georg Fuellen et al.
Steffen Israel et al.
Investigations of genes required in early mammalian development are complicated by protein deposits of maternal products, which continue to operate after the gene locus has been disrupted. This leads to delayed phenotypic manifestations and...
LncRNA LINC01088 inhibits the function of trophoblast cells, activates the MAPK-signaling pathway and associates with recurrent pregnancy loss [0.03%]
长链非编码RNA LINC01088通过抑制滋养细胞功能并激活MAPK信号通路与复发性流产相关
Hui Zhao,Yali Li,Nana Dong et al.
Hui Zhao et al.
Long noncoding RNAs (lncRNAs) have been reported to be involved in various cellular processes and to participate in a variety of human diseases. Recently, increasing studies have reported that lncRNAs are related to many reproductive diseas...
Acetylcholine ameliorated hypoxia-induced oxidative stress and apoptosis in trophoblast cells via p38 MAPK/NF-κB pathway [0.03%]
乙酰胆碱通过p38MAPK/NF-κB通路改善胎盘细胞缺氧诱导的氧化应激和凋亡
Zheng Wang,Gongxiao Zhao,Abdoulaye Issotina Zibrila et al.
Zheng Wang et al.
Hypoxia-induced oxidative stress and apoptosis of trophoblast are involved in the pathogenesis of preeclampsia (PE). Extensive research reports that the principal vagal neurotransmitter acetylcholine (ACh) shows anti-oxidative and anti-apop...
Increased miR-6875-5p inhibits plasmacytoid dendritic cell differentiation via the STAT3/E2-2 pathway in recurrent spontaneous abortion [0.03%]
miR-6875-5p上调通过STAT3/E2-2信号通路抑制浆细胞样树突状细胞分化在复发性流产中的作用研究
Xiao-Xiao Zhu,Xun-Qiang Yin,Guo-Zhen Hei et al.
Xiao-Xiao Zhu et al.
Recurrent spontaneous abortion (RSA) is a common complication of early pregnancy. Dendritic cells (DCs) are thought to confer fetal-maternal immunotolerance and play a crucial role in ensuring a successful pregnancy. A decrease of plasmacyt...
Daniela Bebbere,David F Albertini,Giovanni Coticchio et al.
Daniela Bebbere et al.
Since its recent discovery, the subcortical maternal complex (SCMC) is emerging as a maternally inherited and crucial biological structure for the initial stages of embryogenesis in mammals. Uniquely expressed in oocytes and preimplantation...
Nicoletta Tarozzi,Marco Nadalini,Giovanni Coticchio et al.
Nicoletta Tarozzi et al.
The sperm is essential for reconstitution of embryonic diploidy and highly specialized developmental functions. Immediately after gamete fusion, the sperm-borne PLC-zeta triggers activation, generating intracellular free Ca2+ oscillations. ...
Reverse transcription priming methods affect normalisation choices for gene expression levels in oocytes and early embryos [0.03%]
逆转录引物法影响卵母细胞和早期胚胎基因表达水平的归一化选择
Bo Yu,Helena T A van Tol,Tom A E Stout et al.
Bo Yu et al.
Mammalian oocytes and embryos rely exclusively on maternal mRNAs to accomplish early developmental processes. Since oocytes and early embryos are transcriptionally silent after meiotic resumption, most of the synthesised maternal mRNA does ...
Cortisol induces follicle regression, while FSH prevents cortisol-induced follicle regression in pigs [0.03%]
皮质醇诱导卵泡退化，而FSH防止皮质醇诱导的卵泡退化
Tomoya Nakanishi,Asako Okamoto,Maki Ikeda et al.
Tomoya Nakanishi et al.
During follicular development, a few dominant follicles develop to large antral dominant follicles, whereas the remaining follicles undergo atretic degeneration. Because vascularization on the follicular surface is a morphological feature o...
Comparative Study
Molecular human reproduction. 2021 Jul 1;27(7):gaab038. DOI:10.1093/molehr/gaab038 2021
miRNA-149 targets PARP-2 in endometrial epithelial and stromal cells to regulate the trophoblast attachment process [0.03%]
微小核糖核酸-149通过靶向子宫内膜上皮和间质细胞中的PARP-2调节合体细胞的附着过程
Upendra Kumar Soni,Sangappa Basanna Chadchan,Rakesh Kumar Gupta et al.
Upendra Kumar Soni et al.
Embryo implantation is a highly complex process involving many regulatory factors, including several micro RNAs (miRNAs/miRs). One miRNA present in the stromal cells of normal endometrium is miR-149, which targets poly (ADP-ribose) polymera...
Deciphering balanced translocations in infertile males by next-generation sequencing to identify candidate genes for spermatogenesis disorders [0.03%]
下一代测序解析不育男性染色体易位候选基因以识别精子发生障碍相关基因
T Yammine,N Reynaud,H Lejeune et al.
T Yammine et al.
Male infertility affects about 7% of the general male population. Balanced structural chromosomal rearrangements are observed in 0.4-1.4% of infertile males and are considered as a well-established cause of infertility. However, underlying ...