Induction of Male Neogametogenesis in a Three-Dimensional Microenvironment Supporting Successful Fertilization and Proper Embryo Development [0.03%]
三维微环境诱导雄性新生殖细胞的产生并支持成功受精和正常胚胎发育
Eros Lari,Lily Ng,Philip Xie et al.
Eros Lari et al.
In regenerative medicine, several attempts have been made to produce functional de novo gametes from mouse embryonic stem cells by utilizing 3D culture systems. We attempted to perform neogametogensis in a novel 3D niche to generate neo-gam...
Justine Fischoeder,Jai G Marathe,Deborah J Anderson et al.
Justine Fischoeder et al.
Male fertility depends on sperm motility, which enables sperm to traverse the female reproductive tract to the site of fertilization. Soluble adenylyl cyclase (sAC) is a key regulator of sperm motility defining it as a promising non-hormona...
Functional heterogeneity in trophoblast stem cells derived from recurrent pregnancy loss products of conception [0.03%]
复发性流产妊娠产物来源的合体干细胞具有功能异质性
Qi Fu,Keisuke Kozai,Xingrao Ke et al.
Qi Fu et al.
Recurrent pregnancy loss (RPL), defined as two or more consecutive miscarriages, affects 1-5% of couples attempting to conceive and most frequently occurs between 6 and 8 weeks of gestation, coinciding with critical stages of placental deve...
Investigating the role of a testis-expressed gene Tex2 in spermatogenesis in mice [0.03%]
泰文2基因在小鼠精子发生中的作用研究
Guicheng Zhao,Suyan Wang,Gan Shen et al.
Guicheng Zhao et al.
The Testis-expressed (TEX/Tex) genes are highly expressed in the testes of various species. Several members of the TEX catalog have been suggested to play a role in spermatogenesis, but the functions of most members remain unknown. Here, we...
Circulating Transfer RNA Related Fragment Abundance After Experimental Endometriosis Induction in Baboons [0.03%]
实验性子宫内膜异位症诱导后雌性犬科动物血液循环中转运RNA相关片段含量的变化规律
Hanna Surmann,Ramanaiah Mamillapalli,Joshi Niraj et al.
Hanna Surmann et al.
Endometriosis is a chronic systemic disease affecting approximately 10-15% of women of reproductive age, often resulting in chronic pelvic pain and infertility. Despite its high prevalence, diagnosis is frequently delayed. Transfer RNA-deri...
Beyond Neurobiology: Cellular Prion Protein (PRNP) as an Emerging Regulator of Decidual and Utero-Placental Vascular Function [0.03%]
超越神经生物学：细胞型朊蛋白（PRNP）作为蜕膜和母胎血管功能新兴调节因子的作用
Rumela Bose Banerjee,Rupasri Ain
Rumela Bose Banerjee
The establishment of a functional utero-placental interface depends on the precise temporal and spatial coordination of blastocyst attachment, decidual transformation, trophoblast invasion, and uterine spiral artery remodelling (SAR). Disru...
Alfonso Martinez Arias,Andre Dias,Maneesha Inamdar
Alfonso Martinez Arias
ART has transformed clinical practice but still face modest success rates, poorly defined implantation conditions, and persistent gaps in understanding early human development. At the same time, research in human reproductive biology remain...
Vaginal Escherichia coli infection impairs ovarian homeostasis: Phenotypic characterization and mechanistic insights [0.03%]
阴道大肠杆菌感染损害卵巢稳态：表型特征和机制见解
Pingping Lin,Qianqian Lu,Xiaojing Hou et al.
Pingping Lin et al.
Premature ovarian insufficiency (POI), a condition characterized by the loss of ovarian function before age 40, has emerged as a critical contributor to declining global fertility rates and the increasing prevalence of female infertility. G...
Glycolytic reprogramming and MYH10 K1520 lactylation mediate eutopic endometrial collagen I deposition driven by PKM2-packaged ectopic endometrial extracellular vesicles [0.03%]
糖酵解重构和MYH10 K1520 乳酰化介导PKM2包装的异位子宫内膜外泌体驱动的同种子宫内膜I型胶原沉积
Liang Gao,Shiming Wang,Jingyu Zhang et al.
Liang Gao et al.
Endometriosis (EMs) is characterized by ectopic lesions that disrupt endometrial decidualization, a process frequently accompanied by aberrant collagen deposition and closely linked to clinical infertility. Extracellular vesicles (EVs) are ...
Somatic mutations in endometrial epithelium: biological insights and emerging in vitro models [0.03%]
子宫内膜上皮的体细胞性变异：生物学见解及新兴体外模型
Sugarniya Subramaniam,Caroline E Gargett,Harriet C Fitzgerald et al.
Sugarniya Subramaniam et al.
The human endometrium is a complex, dynamic and poorly understood tissue involving monthly cyclical regeneration likely from adult stem/progenitor cells. This regeneration is associated with reproductive pathologies, such as endometriosis a...