Lysine methyltransferase SETD7 coordinates the emergence of mature and senescent subpopulations during the decidualization of endometrial stromal cells [0.03%]
赖氨酸甲基转移酶SETD7在内膜间质细胞蜕膜化过程中调控成熟和衰老亚群的产生
Аlina O Konyushatova,Pavel I Deryabin,Anastasia P Melnik et al.
Аlina O Konyushatova et al.
Stepwise decidualization of endometrial stromal cells (EnSC) mediates the ability of the endometrium to respond to embryo quality, determining whether to permit or restrict its implantation. Currently, epigenetic mechanisms are recognized a...
A matrix-free 3D in vitro follicle culture system in mice exhibits enhanced oocyte meiotic and developmental competence compared to hydrogel encapsulation [0.03%]
一种无矩阵的三维体外卵泡培养系统比水凝胶包埋培养在小鼠中表现出增强的卵母细胞减数分裂能力和发育能力
Aimilia Zisiadi,Katy Billooye,Ellen Anckaert
Aimilia Zisiadi
In vitro follicle culture (IFC) is an emerging fertility preservation alternative for women and children with cancer. Because two-dimensional (2D) IFC results in oocytes of suboptimal quality in mice and cannot support follicle growth in hu...
Eutopic macrophages facilitate endometriosis progression via ferroptosis-mediated release of S100A9 [0.03%]
铁死亡介导的S100A9释放促进异位巨噬细胞促进子宫内膜异位症进展
Chunying Ye,Panmei Ma,Nana Li et al.
Chunying Ye et al.
Endometriosis is a chronic inflammatory disorder in which immune cells, specifically macrophages, play a pivotal yet incompletely understood role. Aberrations within the eutopic endometrium are implicated in the initiation and progression o...
Overexpression of high affinity Type I adenosine receptors promotes the growth of uterine leiomyomas [0.03%]
I型高亲和力腺苷受体过度表达促进子宫平滑肌瘤的生长
Rodrigo Rosado,Xiaofang Guo,Jake Rymer et al.
Rodrigo Rosado et al.
Leiomyomas are benign proliferations of uterine smooth muscle found in 60% of women. A spatial redistribution of ecto-5'-nucleotidase (CD73, NT5E) that results in reduced extracellular concentrations of adenosine has recently been described...
Early signaling pathways during in vitro culture of isolated primordial follicles [0.03%]
体外培养卵原基窦状小 follicle早期信号通路的研究
Pritha Dey,Noemi Monferini,Ludovica Donadini et al.
Pritha Dey et al.
The ability to grow undifferentiated oocytes in vitro from primordial follicles would increase the availability of fully grown oocytes in fertility preservation programs and other downstream applications. To date, the development of living ...
Mechanical signal-mediated mitochondria-endoplasmic reticulum contacts modulate Leydig cell testosterone biosynthesis during testis development [0.03%]
机械信号介导的线粒体-内质网接触在睾丸发育过程中调节类固醇分泌和间质细胞雄激素生物合成
Jiahong Wu,Ruiling He,Zeyu Xu et al.
Jiahong Wu et al.
In males, 95% of testosterone is synthesized by Leydig cells, and a deficiency in this synthesis will cause metabolic disorders and multiple organ dysfunction. Testosterone deficiency is not only affected by aged or diseased Leydig cells, w...
Alterations in the abundance of protamine proteoforms related to sperm chromatin packaging, obesity and age in normozoospermic men [0.03%]
正常精子生成男性的组蛋白乙酰化和精胺甲基化状态与肥胖和年龄的关系研究
Judit Castillo,Marina Gay,Alberto De La Iglesia et al.
Judit Castillo et al.
Protamines are considered among the most relevant sperm proteins because of their functional implications on paternal genome packaging and protection. Although the proteomic evaluation of protamines is technically challenging, mass spectrom...
Mosaicism is more than meets the eye: transcriptional consequences of blastocyst mosaicism [0.03%]
mosaicism的转录后效应：囊胚期mosaicism的后果
Brandon A Wyse,Noga Fuchs Weizman,Rima Kharonsky et al.
Brandon A Wyse et al.
Blastocyst mosaicism is increasingly detected due to advances in preimplantation genetic testing for aneuploidy (PGT-A). While some mosaic embryos result in a live birth, there are reports of altered implantation potential. Various approach...
Single-cell metabolomics reveals that bisphosphoglycerate mutase influences oocyte maturation through glucose metabolism [0.03%]
单细胞代谢组学揭示二磷酸甘油酸互变异构酶通过糖酵解影响卵母细胞成熟
Jing Wang,Qiang Liu,Zhiqiang Yan et al.
Jing Wang et al.
The spatiotemporal turnover of metabolites is essential for oocyte maturation, embryonic development, and cell lineage differentiation. Here, we analyzed the metabolic profiles of individual living mouse oocytes and studied how bisphosphogl...
Cellular Prion: A novel regulator of decidual cell function at the maternal fetal interface [0.03%]
细胞型朊病毒：一种新的调节母胎界面蜕膜细胞功能因子
Swarnali Dey,Tamal Kanti Gope,Rupasri Ain
Swarnali Dey
Cellular prion (PRNP) is a GPI anchored extrinsic membrane glycoprotein, which has been implicated in mouse decidualization. However, the molecular function of this protein, in mouse decidua is not known. In this report, we have characteriz...