Prophylactic treatment with progesterone decreases murine miscarriage by suppressing the immunostimulatory activity of macrophages [0.03%]
孕酮预防性治疗通过抑制巨噬细胞的免疫刺激活性减少小鼠流产
Yuki Kaito,Hajime Ino,Yumi Horii et al.
Yuki Kaito et al.
Miscarriage and preterm birth (PB) remain major challenges in obstetric care and are often associated with excessive inflammation at the feto-maternal interface. Although the role of progesterone (P4) in maintaining pregnancy is well known,...
Michele Boiani,Francesca E Duncan
Michele Boiani
Julian K Christians
Julian K Christians
It is common to sex-stratify analyses of omics data and to report effects as "sex-specific" when they are significant in only one sex. However, when analysing hundreds or thousands of molecules, this approach will yield many spurious "sex-s...
Meta-analysis examining fetal sex-specific placental DNA methylation intensities and estimated cell composition post in vitro fertilization [0.03%]
荟萃分析：体外受精后胎盘DNA甲基化强度和估算的细胞组成性别特异性差异
Melanie Lemaire,Wei Q Deng,Keaton W Smith et al.
Melanie Lemaire et al.
Infertility impacts up to 17.5% of reproductive-aged couples worldwide. To aid in conception, many couples turn to assisted reproductive technology, such as IVF. IVF can introduce both physical and environmental stressors that may alter DNA...
Neutrophils in the female reproductive tract: immune interactions and sperm adaptations [0.03%]
生殖道中的中性粒细胞：免疫作用与精子适应性
Priksha Kuni,Gagan Kajla,Gagandeep Kaur Gahlay
Priksha Kuni
Human fertilization is a coordinated process involving nteraction of sperm with the oocyte. As the sperm pass through the female reproductive tract (FRT), they are presented with numerous challenges. These include navigating through highly ...
The impact of maternal diet-induced obesity on offspring primordial oocyte mitochondria at birth and at weaning [0.03%]
母体饮食诱导肥胖对后代出生和断奶时原始卵泡线粒体的影响
Waleed F A Marei,Inne Xhonneux,Axelle Buydens et al.
Waleed F A Marei et al.
Maternal diet-induced obesity (DIO) may affect adult offspring oocyte quality due to mitochondrial dysfunction. Here, we investigated whether offspring of DIO mothers exhibit mitochondrial abnormalities in their primordial follicle oocytes ...
Bitter taste signaling pathway is required for spermatogenesis and maintenance of male fertility in mice [0.03%]
苦味信号通路通过调控小鼠精子发生维持雄性生育力
Feng Li,Ling-Ling Liu,Bo-Wen Niu et al.
Feng Li et al.
Recently, the expression of bitter taste receptors and their downstream taste signaling cascade have been widely found outside the gustatory system, indicating important physiological functions of bitter taste receptors in various extraoral...
S14G-Humanin ameliorates ovarian dysfunction in a cyclophosphamide-induced premature ovarian insufficiency mouse model [0.03%]
人源蛋白humanin改善环磷酰胺诱导的卵巢早衰小鼠模型中的卵巢功能异常
Jin Huang,Dandan Zhang,Liping Zou et al.
Jin Huang et al.
Premature ovarian insufficiency (POI) is a major cause of female infertility, for which effective therapies remain limited. S14G-Humanin (HNG), a potent analogue of Humanin, exhibits strong antioxidant and anti-apoptotic properties, and has...
ACTRT2 deficiency increases spermatogonia vulnerability to ferroptosis [0.03%]
ACTRT2缺乏增加精原细胞对铁死亡的敏感性
Haicheng Chen,Yanqing Li,Daosheng Luo et al.
Haicheng Chen et al.
The death of spermatogonia leads to decreased spermatogenesis and male infertility. Indeed, spermatogonia are vulnerable to various external damage factors and would be caused to cell death. However, the mechanism is still unclear. In this ...
Fibroblast growth factor signaling and spermatogonial stem cell self-renewal [0.03%]
纤维生长因子信号和精原干细胞自我更新
Ming Yang,Eoin C Whelan,Youyue Zeng et al.
Ming Yang et al.
Spermatogonial stem cells (SSCs) serve as the foundational units for all adult male germ cells, playing a critical role in male fertility. These cells are characterized by their unique ability to balance self-renewal and differentiation, en...