Macrophage-associated immune checkpoint CD47 blocking ameliorates endometriosis [0.03%]
巨噬细胞相关免疫检查点CD47阻滞可缓解子宫内膜异位症
Jing Li,Shumin Yan,Qiuju Li et al.
Jing Li et al.
Peritoneal macrophages play a significant role in the progression of endometriosis (EM), but their functional differentiation is still unclear, and their phagocytic ability is weak. CD47-signal-regulated protein α (SIRPα) and PD-L1-PD-1 a...
On the origins and fate of chromosomal abnormalities in human preimplantation embryos: an unsolved riddle [0.03%]
人类前着床胚胎染色体异常的发生和结局：一个未解之谜
Marius Regin,Claudia Spits,Karen Sermon
Marius Regin
About 8 out of 10 human embryos obtained in vitro harbour chromosomal abnormalities of either meiotic or mitotic origin. Abnormalities of mitotic origin lead to chromosomal mosaicism, a phenomenon that has sparked much debate lately as it c...
A rare frameshift mutation in SYCP1 is associated with human male infertility [0.03%]
SYCP1基因的一个罕见移码突变与男性不孕相关
Soheila Nabi,Masomeh Askari,Maryam Rezaei-Gazik et al.
Soheila Nabi et al.
Proper assembly of the synaptonemal complex is essential for successful meiosis, and impairments in the process lead to infertility. Meiotic transverse filament proteins encoded by the SYCP1 (synaptonemal complex protein 1) gene are one of ...
Inhibition of the NLRP3 inflammasome by progesterone is attenuated by abnormal autophagy induction in endometriotic cyst stromal cells: implications for endometriosis [0.03%]
孕酮诱导的NLRP3炎性小体抑制作用在子宫内膜异位囊壁成纤维细胞中被异常增强的自噬所削弱：对子宫内膜异位症的意义
JongYeob Choi,MinWha Jo,EunYoung Lee et al.
JongYeob Choi et al.
The NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome is a cytosolic multi-protein complex that induces inflammation and is known to be regulated negatively by autophagy. Previous studies reported an abnormal induction of aut...
A reproductive science perspective: deliberations on the stem cell guidelines update [0.03%]
从生殖医学角度论干细胞指南修订几点思考
Michele Boiani,Francesca E Duncan;MHR-ISSCR guidelines working group
Michele Boiani
GAS6-mediated dialogue between decidual stromal cells and macrophages is essential for early pregnancy maintenance by inducing M2-like polarization and cell proliferation of decidual macrophages [0.03%]
Gas6介导的蜕膜基质细胞和巨噬细胞之间的对话通过诱导蜕膜巨噬细胞向M2样极化和增殖对于维持早期妊娠至关重要
Jing-Cong Dai,Jia-Yan Yang,Rui-Qi Chang et al.
Jing-Cong Dai et al.
Maternal immunotolerance towards the semi-allogeneic foetus is critical for normal pregnancy (NP). As a secretory protein, growth arrest-specific factor 6 (GAS6) promotes cancer progression by inducing the conversion of tumour-associated ma...
Gabriela Carrasquel Martínez,Andrés Aldana,Jorge Carneiro et al.
Gabriela Carrasquel Martínez et al.
Mammalian sperm capacitation is a prerequisite for successful fertilization. Capacitation involves biochemical and physiological modifications of sperm as they travel through the female reproductive tract. These modifications prepare the sp...
Direct visualization of pre-protamine 2 detects protamine assembly failures and predicts ICSI success [0.03%]
直接可视化预protamine 2检测protamine组装失败并预测ICSI成功
Maryam Rezaei-Gazik,Alexandra Vargas,Amir Amiri-Yekta et al.
Maryam Rezaei-Gazik et al.
Histone-to-protamine transition is an essential step in the generation of fully functional spermatozoa in various mammalian species. In human and mouse, one of the two protamine-encoding genes produces a precursor pre-protamine 2 (pre-PRM2)...
Transcriptomic analysis reveals myometrial topologically associated domains linked to the onset of human term labour [0.03%]
转录组分析发现了与人类足月分娩发动相关的子宫平滑肌拓扑结构关联域
Sonika Tyagi,Eng-Cheng Chan,Daniel Barker et al.
Sonika Tyagi et al.
Changes in cell phenotype are thought to occur through the expression of groups of co-regulated genes within topologically associated domains (TADs). In this paper, we allocate genes expressed within the myometrium of the human uterus durin...
Exosomes released from Sertoli cells contribute to the survival of Leydig cells through CCL20 in rats [0.03%]
生精细胞释放的外泌体通过CCL20促进大鼠支持细胞的存活
Yi Ma,Yan Zhou,Sha-Sha Zou et al.
Yi Ma et al.
Reciprocal communication between Sertoli and Leydig cells occurs in the testes; however, the detailed mechanisms involved are not completely understood. Exosomes can communicate within neighboring or distant cells to regulate cell function....