Chromatin Accessibility Analysis from Fresh and Cryopreserved Human Ovarian Follicles [0.03%]
取自新鲜和冷冻保存的人类卵泡的染色质可及性分析
Jennifer Shannon,Aishwarya Sundaresan,Orhan Bukulmez et al.
Jennifer Shannon et al.
Understanding how gene regulatory elements influence ovarian follicle development has important implications in clinically relevant settings. This includes understanding decreased fertility with age and understanding the short-lived graft f...
Cannabis significantly alters DNA methylation of the human ovarian follicle in a concentration-dependent manner [0.03%]
大麻通过浓度依赖性方式显著改变人类卵泡的DNA甲基化状态
Noga Fuchs Weizman,Brandon A Wyse,Janice Montbriand et al.
Noga Fuchs Weizman et al.
Cannabis is increasingly consumed by women of childbearing age, and the reproductive and epigenetic effects are unknown. The purpose of this study was to evaluate the potential epigenetic implications of cannabis use on the female ovarian f...
Evidence for TET-mediated DNA demethylation as an epigenetic alteration in cumulus granulosa cells of women with polycystic ovary syndrome [0.03%]
TET介导的DNA去甲基化作为多囊卵巢综合征患者的颗粒细胞表观遗传改变的证据
Pooja Sagvekar,Gayatri Shinde,Vijay Mangoli et al.
Pooja Sagvekar et al.
Peripheral and tissue-specific alterations in global DNA methylation (5-methylcytosine (5mC)) and DNA hydroxymethylation (5-hydroxymethylcytosine (5hmC)) profiles have been identified as both biomarkers for disease prediction and as hallmar...
Elevated prohibitin 1 expression mitigates glucose metabolism defects in granulosa cells of infertile patients with endometriosis [0.03%]
上调 prohibitin 1 表达可缓解子宫内膜异位症不孕患者颗粒细胞糖代谢异常
Jingqin Mao,Jingyi Zhang,Lingbo Cai et al.
Jingqin Mao et al.
Endometriosis is a common disease in women of childbearing age and is closely associated with female infertility. However, the pathogenesis of endometriosis-related infertility is still not fully understood. Prohibitin 1 (PHB1), a highly co...
Nucleoporin37 may play a role in early embryo development in human and mice [0.03%]
核孔蛋白37可能在人和小鼠早期胚胎发育中发挥作用
Yawen Peng,Jiandong Shen,Yan Gao et al.
Yawen Peng et al.
Maternal-effect genes (MEGs) play an important role in maintaining the survival and development of mammalian embryos at the cleavage stage after fertilization. Despite long-term efforts, the MEGs that regulate preimplantation embryo develop...
The roles of ADAMDEC1 in trophoblast differentiation during normal pregnancy and preeclampsia [0.03%]
ADAMDEC1在正常妊娠及子痫前期滋养细胞分化中的作用
Zhuo-Hang Li,Xia Li,Fang-Fang Li et al.
Zhuo-Hang Li et al.
Human cytotrophoblast (CTB) differentiation into syncytiotrophoblast (STB) is essential for placental formation and function. Understanding the molecular mechanisms involved in trophoblast differentiation is necessary as it would help in th...
Uterine-specific SIRT1 deficiency confers premature uterine aging and impairs invasion and spacing of blastocyst, and stromal cell decidualization, in mice [0.03%]
子宫特异性SIRT1缺乏会导致小鼠子宫提前衰老并影响胚胎着床及子宫内膜蜕膜化功能障碍
Magdalina J Cummings,Hongyao Yu,Sudikshya Paudel et al.
Magdalina J Cummings et al.
A distinct age-related alteration in the uterine environment has recently been identified as a prevalent cause of the reproductive decline in older female mice. However, the molecular mechanisms that underlie age-associated uterine adaptabi...
Bi-allelic variants in SHOC1 cause non-obstructive azoospermia with meiosis arrest in humans and mice [0.03%]
SHOC1双等位基因变异导致人类和小鼠非梗阻性无精子症伴减数分裂停滞
Weili Wang,Lanlan Meng,Jiaxin He et al.
Weili Wang et al.
Meiosis is pivotal to gametogenesis and fertility. Meiotic recombination is a mandatory process that ensures faithful chromosome segregation and generates genetic diversity in gametes. Non-obstructive azoospermia (NOA) caused by meiotic arr...
Human pluripotent stem cell-derived cells endogenously expressing follicle-stimulating hormone receptors: modeling the function of an inactivating receptor mutation [0.03%]
人多能干细胞来源的内源性表达卵泡刺激素受体的细胞： Modeling FSH 受体失活突变的功能
K Lundin,K Sepponen,P Väyrynen et al.
K Lundin et al.
Follicle-stimulating hormone (FSH) is crucial in the development and regulation of reproductive functions. The actions of human FSH and its receptor (FSHR) and mutations therein have mainly been studied using in vivo models, primary cells, ...
Epigenetic regulation of epithelial to mesenchymal transition: a trophoblast perspective [0.03%]
从滋养细胞角度探讨上皮间质转化的表观遗传调控
Jaganmoy Choudhury,Deepak Pandey,Pradeep Kumar Chaturvedi et al.
Jaganmoy Choudhury et al.
Epigenetic changes alter the expression of genes at both pre- and post-transcriptional levels without changing their DNA sequence. Accumulating evidence suggests that such changes can modify cellular behavior and characteristics required du...