Alteration of RNA modification signature in human sperm correlates with sperm motility [0.03%]
人精子RNA修饰谱式与精子活力的相关性研究
Huanping Guo,Xipeng Shen,Hua Hu et al.
Huanping Guo et al.
RNA modifications, which are introduced post-transcriptionally, have recently been assigned pivotal roles in the regulation of spermatogenesis and embryonic development. However, the RNA modification landscape in human sperm is poorly chara...
Evidence of a role for cAMP in mitochondrial regulation in ovarian granulosa cells [0.03%]
cAMP通过环核苷酸磷酸二酯酶3B依赖性机制调节小鼠卵巢颗粒细胞线粒体功能的证据
Melanie Kaseder,Nina Schmid,Katja Eubler et al.
Melanie Kaseder et al.
In the ovary, proliferation and differentiation of granulosa cells (GCs) drive follicular growth. Our immunohistochemical study in a non-human primate, the Rhesus monkey, showed that the mitochondrial activity marker protein cytochrome c ox...
Sperm degradation after vasectomy follows a sperm chromatin fragmentation-dependent mechanism causing DNA breaks in the toroid linker regions [0.03%]
输精管切除术后精子降解遵循一种以精子染色质片段化依赖机制导致环状连接区DNA断裂的模式
Jordi Ribas-Maynou,Hieu Nguyen,Raquel Valle et al.
Jordi Ribas-Maynou et al.
Vasectomy is a widely used surgical technique creating an obstructive azoospermia. Although sperm cannot be ejaculated, the testis maintains sperm production in vasectomized males. The continuous accumulation of sperm deposited in the epidi...
Wanglong Xiao,Mengdi Yu,Yan Yuan et al.
Wanglong Xiao et al.
Sperm are guided through the female reproductive tract. A temperature difference of about 2°C exists between the storage site and fertilization site of the mammalian oviduct, leading to the hypothesis that sperm can sense and swim towards ...
Transcriptional profiles of genes related to mitochondrial aging in placental pathologies [0.03%]
与线粒体衰老相关基因在胎盘病理状态下的转录谱型研究
Lucy A Bartho,Daniel R McKeating,Natalie J Hannan et al.
Lucy A Bartho et al.
As the placenta develops across gestation, the mitochondria and other organelles like the endoplasmic reticulum (ER) must continue to adapt to stressors such as oxidative stress. As pregnancy approaches term, these stressors may contribute ...
Pathogenic variant in ACTL7A causes severe teratozoospermia characterized by bubble-shaped acrosomes and male infertility [0.03%]
ACTL7A致病突变引起以气泡形顶体为主特征的严重畸形精子症男性不育
Jing Dai,Yongzhe Chen,Qi Li et al.
Jing Dai et al.
Teratozoospermia is a common factor associated with male infertility. However, teratozoospermia characterized by bubble-shaped acrosomes (BSAs) has not yet been identified in men and the causative genes are unknown. The present study is of ...
Functional significance of mouse seminal vesicle sulfhydryl oxidase on sperm capacitation in vitro [0.03%]
Sulfhydryl氧化酶在小鼠精子体外获能中的功能意义
Rubhadevi Balu,Shiyam Sundar Ramachandran,Amala Mathimaran et al.
Rubhadevi Balu et al.
During ejaculation, cauda epididymal spermatozoa are suspended in a protein-rich solution of seminal plasma, which is composed of proteins mostly secreted from the seminal vesicle. These seminal proteins interact with the sperm cells and br...
Role of genomic DNA methylation in PCOS pathogenesis: a systematic review and meta-analysis involving case-controlled clinical studies [0.03%]
DNA甲基化在多囊卵巢综合征发病机制中的作用：病例对照临床研究的系统评价和荟萃分析
Kajal Rawat,Arushi Sandhu,Vipasha Gautam et al.
Kajal Rawat et al.
Polycystic ovary syndrome (PCOS) is often associated with aberrant DNA methylation. Despite the advances in diagnostics and treatment of PCOS, the pathophysiological mechanism remains unknown. Several genes are epigenetically dysregulated i...
Early pregnancy human decidua gamma/delta T cells exhibit tissue resident and specific functional characteristics [0.03%]
早期妊娠人类蜕膜γδT细胞具有组织常驻和功能特性
Shuo Yang,Ting Feng,ChengYong Ma et al.
Shuo Yang et al.
A successful pregnancy is a complicated process that builds upon two aspects of the maternal immune system that need to be balanced. As one of the indispensable groups of immune cell at the maternal-fetal interface, the decidual gamma/delta...
Novel bi-allelic variants in KASH5 are associated with meiotic arrest and non-obstructive azoospermia [0.03%]
KASH5新双等位基因变异与减数分裂停滞和非阻塞性无精子症相关
Chao Yang,Xiaoqi Lin,Zhiyong Ji et al.
Chao Yang et al.
KASH5 is an essential component of the LINC (linker of the nucleoskeleton and cytoskeleton) complex that regulates chromosome movements and nuclear envelope (NE) remodeling in mouse spermatocytes during meiosis prophase I, but its expressio...