In vivo promotion of primordial follicle activation by stem cell factor treatment in mice with premature ovarian insufficiency and advanced age [0.03%]
干细胞因子活化小鼠原始卵泡研究进展
Yibo Wang,Jiawei Zhang,Jing Liang et al.
Yibo Wang et al.
Dormant primordial follicles (PFs) are the most abundant reproductive resource in mammalian ovaries. With advances in the mechanism of study of the regulation of PF activation, PFs have been used to improve fertility in clinical practice. A...
Segmental aneuploid hotspots identified across the genome concordant on reanalysis [0.03%]
跨基因组一致识别片段非整倍体热点区域
Keelee J McCarty,Mary E Haywood,Rachel Lee et al.
Keelee J McCarty et al.
The aim of this study was to characterize a large set of full segmental aneuploidies identified in trophectoderm (TE) biopsies and evaluate concordance in human blastocysts. Full segmental aneuploid errors were identified in TE biopsies (n ...
Senescent endometrial stromal cells transmit reactive oxygen species to the trophoblast-like cells and impair spreading of blastocyst-like spheroids [0.03%]
衰老的子宫内膜基质细胞向类绒毛膜细胞传递活性氧并妨碍类囊胚球体的扩散
P I Deryabin,J S Ivanova,A V Borodkina
P I Deryabin
Successful implantation requires a fine-tuned dialog between the invading embryo and the maternal endometrium. Recently, we discovered that premature senescence of endometrial stromal cells (EnSC) might mediate improper decidual transformat...
Caitlyn Myers,Mary Catherine Hastert,Gail A Cornwall
Caitlyn Myers
The epididymal lumen is an immunologically distinct environment. It maintains tolerance for the naturally antigenic spermatozoa to allow their maturation into functional cells while simultaneously defending against pathogens that can ascend...
Metabolic and secretory recovery of slow frozen-thawed human ovarian tissue in vitro [0.03%]
慢速冻融人卵巢组织的体外代谢和分泌功能恢复
Rebekka Einenkel,Andreas Schallmoser,Nicole Sänger
Rebekka Einenkel
Within the options available for fertility preservation, cryopreservation of ovarian cortical tissue has become an important technique. Freezing and thawing procedures have been optimized to preserve tissue integrity and viability. However,...
Mitochondrial aggregation caused by cytochalasin B compromises the efficiency and safety of three-parent embryo [0.03%]
细胞松弛素B诱导的线粒体聚集降低三亲本胚胎的效率和安全性
Ying Li,Sanbao Shi,Jin Yuan et al.
Ying Li et al.
It is widely accepted that cytochalasin B (CB) is required in enucleation of the oocyte in order to stabilize the cytoplasm. However, CB treatment results in the uneven distribution of mitochondria, with aggregation towards the nucleus, whi...
Predicted COVID-19 molecular effects on endometrium reveal key dysregulated genes and functions [0.03%]
预测的COVID-19分子对子宫内膜的影响揭示了关键的失调基因和功能
I Henarejos-Castillo,A Devesa-Peiro,L de Miguel-Gomez et al.
I Henarejos-Castillo et al.
COVID-19 exerts systemic effects that can compromise various organs and systems. Although retrospective and in silico studies and prospective preliminary analysis have assessed the possibility of direct infection of the endometrium, there i...
Progesterone suppresses podocalyxin partly by up-regulating miR-145 and miR-199 in human endometrial epithelial cells to enhance receptivity in in vitro models [0.03%]
孕酮通过在体外模型中上调人子宫内膜上皮细胞中的miR-145和miR-199来抑制podocalyxin以提高接受性
Manizha Shekibi,Sophea Heng,Yao Wang et al.
Manizha Shekibi et al.
Establishment of endometrial surface receptivity is crucial for the initiation of embryo implantation yet the molecular mechanisms are not well understood, especially in humans. We have recently discovered that podocalyxin (PODXL) is a crit...
Follicle isolation methods reveal plasticity of granulosa cell steroidogenic capacity during mouse in vitro follicle growth [0.03%]
卵泡分离方法揭示了小鼠体外卵泡生长过程中颗粒细胞类固醇生成能力的可塑性
Elnur Babayev,Min Xu,Lonnie D Shea et al.
Elnur Babayev et al.
Follicles are the functional unit of the ovary and several methods have been developed to grow follicles ex vivo, which recapitulate key events of oogenesis and folliculogenesis. Enzymatic digestion protocols are often used to increase the ...
Inhibition of YAP/TAZ-TEAD activity induces cytotrophoblast differentiation into syncytiotrophoblast in human trophoblast [0.03%]
抑制YAP/TAZ-TEAD活性可诱导人滋养细胞的合体化
Tetsuya Mizutani,Makoto Orisaka,Yumiko Miyazaki et al.
Tetsuya Mizutani et al.
During placentation, placental cytotrophoblast (CT) cells differentiate into syncytiotrophoblast (ST) cells and extravillous trophoblast (EVT) cells. In the placenta, the expression of various genes is regulated by the Hippo pathway through...