Systematic assessment of hexavalent chromium-induced damage to male fertility and the preventive role of melatonin: a longitudinal study from the translational point of view [0.03%]
从转化医学角度对六价铬诱导的雄性生殖毒性及褪黑素预防作用的系统评估
Tianjiao Li,Yinghua Lv,Zhili Wu et al.
Tianjiao Li et al.
Chromium (Cr) and its compounds are closely associated with individuals' lives and extensively used in industry. Excessive exposure to hexavalent chromium (Cr(VI)) induces oxidative damage of various organs including the testes, posing a se...
Cyclic processes in the uterine tubes, endometrium, myometrium, and cervix: pathways and perturbations [0.03%]
输卵管、子宫内膜、子宫肌层和宫颈的周期性变化：通路及干扰因素
Sarah J Holdsworth-Carson,Ellen Menkhorst,Jacqueline A Maybin et al.
Sarah J Holdsworth-Carson et al.
This review leads the 2023 Call for Papers in MHR: 'Cyclical function of the female reproductive tract' and will outline the complex and fascinating changes that take place in the reproductive tract during the menstrual cycle. We will also ...
Loss-of-function mutations in IQCN cause male infertility in humans and mice owing to total fertilization failure [0.03%]
IQCN功能丧失型突变通过完全受精失败导致人和小鼠的男性不育
Yulin Wang,Guoyong Chen,Zhenzhen Tang et al.
Yulin Wang et al.
Fertilization failure is a significant manifestation of unexplained male infertility. Previous work has suggested a genetic origin. In this study, we report on a man with unexplained infertility from a large consanguineous marriage family. ...
Abbey C Lissaman,Jane E Girling,Lynsey M Cree et al.
Abbey C Lissaman et al.
Currently, our understanding of hormonal regulation within the female reproductive system is largely based on our knowledge of estrogen and progesterone signalling. However, while the important functions of androgens in male physiology are ...
Elis Torrezan-Nitao,Sean G Brown,Linda Lefievre et al.
Elis Torrezan-Nitao et al.
Exposure of human sperm to progesterone (P4) activates cation channel of sperm (CatSper) channels, inducing an intracellular Ca2+ concentration ([Ca2+]i) transient followed by repetitive [Ca2+]i activity (oscillations), which are believed t...
Escherichia coli inhibits endometriosis by inducing M1 polarity of peritoneal macrophages and the IL-1 signaling pathway [0.03%]
大肠杆菌通过诱导腹膜巨噬细胞M1极化和IL-1信号途径抑制子宫内膜异位症
Shumin Yan,Yufei Huang,Le Xu et al.
Shumin Yan et al.
The development of endometriosis is closely linked to macrophages, and the type M1 macrophage has been hypothesized to play an inhibitory role in its progression. Escherichia coli induces macrophage polarization toward M1 in numerous diseas...
A long-acting recombinant FSH supports high-quality mouse follicle development and oocyte maturation in vitro by coordinating somatic and germ cell transcriptomes [0.03%]
一种长效重组FSH通过协调卵母细胞和颗粒细胞转录组支持小鼠体外卵巢类器官中卵泡发育和卵子成熟
Shao-Yuan Liu,Yan-Chu Li,Xin-Yi Tian et al.
Shao-Yuan Liu et al.
Strategies to maximize individual fertility chances are constant requirements of ART. In vitro folliculogenesis may represent a valid option to create a large source of immature ovarian follicles in ART. Efforts are being made to set up mam...
Functional analysis of rare anti-Müllerian hormone protein-altering variants identified in women with PCOS [0.03%]
罕见的抗苗勒管激素蛋白改变变异在多囊卵巢综合征女性中的功能分析
L Meng,A McLuskey,A Dunaif et al.
L Meng et al.
Recently, rare heterozygous AMH protein-altering variants were identified in women with polycystic ovary syndrome (PCOS), causing reduced anti-Müllerian hormone (AMH) signaling. However, the exact functional mechanism remains unknown. Here...
Semaphorin 4C regulates ovarian steroidogenesis through RHOA/ROCK1-mediated actin cytoskeleton rearrangement [0.03%]
Semaphorin 4C通过RHOA/ROCK1介导的细胞骨架重排调节卵巢类固醇生成
Dan Chen,Chuqing Wu,Simin Wei et al.
Dan Chen et al.
Semaphorins are a family of evolutionarily conserved morphogenetic molecules that were initially found to be associated with axonal guidance. Semaphorin 4C (Sema4C), a member of the fourth subfamily of semaphorins, has been demonstrated to ...