TRPV2, a novel player in the human ovary and human granulosa cells [0.03%]
瞬时受体电位香草素子通道V2是人卵巢及颗粒细胞的新成员
Katja Eubler,Karolina M Caban,Gregory A Dissen et al.
Katja Eubler et al.
The cation channel 'transient receptor potential vanilloid 2' (TRPV2) is activated by a broad spectrum of stimuli, including mechanical stretch, endogenous and exogenous chemical compounds, hormones, growth factors, reactive oxygen species,...
Control of mitochondrial integrity influences oocyte quality during reproductive aging [0.03%]
线粒体完整性影响生殖衰老过程中的卵母细胞质量
Shaihla A Khan,Laura Reed,William B Schoolcraft et al.
Shaihla A Khan et al.
Reduced quality in oocytes from women of advanced maternal age (AMA) is associated with dysfunctional mitochondria. The objective of this study was to investigate the mechanisms controlling mitochondrial quality during maternal aging in mou...
CircKDM5B sponges miR-128 to regulate porcine blastocyst development by modulating trophectoderm barrier function [0.03%]
Circular RNA CircKDM5B通过调节滋养外胚层屏障功能海绵miR-128来调控猪囊胚发育
Di Gao,Xin Wang,Ye-Lian Yan et al.
Di Gao et al.
Circular RNAs (circRNAs), which exert critical functions in the regulation of transcriptional and post-transcriptional gene expression, are found in mammalian cells but their functions in mammalian preimplantation embryo development remain ...
Extravillous trophoblast cell-derived exosomes induce vascular smooth muscle cell apoptosis via a mechanism associated with miR-143-3p [0.03%]
绒毛外滋养细胞源性外泌体通过与miR-143-3p相关机制诱导血管平滑肌细胞凋亡
Hanbo Liu,Miaojuan Chen,Fen Ning et al.
Hanbo Liu et al.
The remodeling of uterine spiral arteries is a complex process requiring the dynamic action of various cell types. During early pregnancy, extravillous trophoblast (EVT) cells differentiate and invade the vascular wall, replacing the vascul...
Return of the forgotten hero: the role of Y chromosome-encoded Zfy in male reproduction [0.03%]
被遗忘英雄的回归：Y染色体编码Zfy在雄性生殖中的作用
Hayden Holmlund,Yasuhiro Yamauchi,Victor A Ruthig et al.
Hayden Holmlund et al.
The Y-linked zinc finger gene ZFY is conserved across eutherians and is known to be a critical fertility factor in some species. The initial studies of the mouse homologues, Zfy1 and Zfy2, were performed using mice with spontaneous Y chromo...
Genetic variants underlying developmental arrests in human preimplantation embryos [0.03%]
人类卵裂期胚胎发育停滞的遗传变异研究
Saffet Ozturk
Saffet Ozturk
Developmental arrest in preimplantation embryos is one of the major causes of assisted reproduction failure. It is briefly defined as a delay or a failure of embryonic development in producing viable embryos during ART cycles. Permanent or ...
Safety of multiple administrations of spermicidal LL-37 antimicrobial peptide into the mouse female reproductive tract [0.03%]
精子杀菌肽LL-37多次重复用于小鼠的安全性研究
Seung Gee Lee,Wongsakorn Kiattiburut,Stephanie C Burke Schinkel et al.
Seung Gee Lee et al.
We have previously demonstrated spermicidal activity of LL-37 antimicrobial peptide on mouse/human sperm and its contraceptive effects in female mice. With its microbicidal action against Neisseria gonorrhoeae, LL-37 warrants development in...
Genome-wide analysis of histone modifications that underlie the dynamic changes in gene expression during decidualization in human endometrial stromal cells [0.03%]
人子宫内膜间质细胞蜕膜化过程中表观遗传重编程的调控机制研究
Isao Tamura,Amon Shiroshita,Taishi Fujimura et al.
Isao Tamura et al.
Human endometrial stromal cells (hESCs) undergo a differentiation process with dramatic changes in cell functions during the menstrual cycle, which is called decidualization. This is an important event for implantation of the embryo and suc...
Kayhan Yakin,Francesko Hela,Ozgur Oktem
Kayhan Yakin
The corpus luteum is the major source of progesterone, the essential hormone for female reproductive function. While progesterone activity has been the subject of extensive research for decades, characterization of non-canonical progesteron...
Specific processing of meiosis-related transcript is linked to final maturation in human oocytes [0.03%]
与人类卵母细胞最终成熟的相关的有丝分裂相关转录本的特异性加工处理有关
Sara Pietroforte,Montserrat Barragan Monasterio,Anna Ferrer-Vaquer et al.
Sara Pietroforte et al.
Human meiosis in oocytes entails an intricate regulation of the transcriptome to support late oocyte growth and early embryo development, both crucial to reproductive success. Currently, little is known about the co- and post-transcriptiona...