Electroacupuncture alleviates intrauterine adhesion through regulating autophagy in rats [0.03%]
电针通过调节自噬缓解大鼠宫腔粘连
Jingyu Liu,Qian Zhu,Yan Pan et al.
Jingyu Liu et al.
Autophagy is a well-conserved metabolic system that maintains homeostasis by relying on lysosomal breakdown. The endometrium of patients with intrauterine adhesion (IUA) and an animal model exhibits impaired autophagy. Autophagy is negative...
Intracellular fraction of zona pellucida protein 3 is required for the oocyte-to-embryo transition in mice [0.03%]
小鼠卵子到胚胎转变需要卵泡膜蛋白3的胞内区段蛋白质
Steffen Israel,Julia Seyfarth,Thomas Nolte et al.
Steffen Israel et al.
In oocyte biology, the zona pellucida has long been known to operate three extracellular functions downstream of the secretory pathway, namely, encasing the oocytes in ovarian follicles, mediating sperm-oocyte interaction, and preventing pr...
hsa_circRNA_BECN1 acts as a ceRNA to promote polycystic ovary syndrome progression by sponging the miR-619-5p/Rab5b axis [0.03%]
hsa_circRNA_BECN1通过海绵吸附miR-619-5P/RAB5B轴促进多囊卵巢综合征的发展并充当竞争性内源RNA
Hairui Fan,Dongjie Zhou,Xiaomei Zhang et al.
Hairui Fan et al.
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease that affects women of reproductive age. It is also a significant cause of infertility. Circular RNAs have been found to have a crucial role in the development and p...
Yun Chen,Chenyun Miao,Ying Zhao et al.
Yun Chen et al.
Inflammasomes are multi-protein complexes localized within immune and non-immune cells that induce caspase activation, proinflammatory cytokine secretion, and ultimately pyroptosis-a type of cell death. Inflammasomes are involved in a varie...
Upregulated TIMP1 facilitates and coordinates myometrial contraction by decreasing collagens and cell adhesive capacity during human labor [0.03%]
TIMP1上调通过减少胶原蛋白和细胞粘附能力来促进和协调人类分娩中的子宫收缩
Junjie Bao,Xiaodi Wang,Lina Chen et al.
Junjie Bao et al.
Myometrial contraction is one of the key events involved in parturition. Increasing evidence suggests the importance of the extracellular matrix (ECM) in this process, in addition to the functional role of myometrial smooth muscle cells, an...
Ovarian stimulation with excessive FSH doses causes cumulus cell and oocyte dysfunction in small ovarian reserve heifers [0.03%]
大剂量FSH卵巢刺激导致小卵巢储备母牛放射冠细胞和卵母细胞功能障碍
Kaitlin R Karl,Peter Z Schall,Zaramasina L Clark et al.
Kaitlin R Karl et al.
Excessive FSH doses during ovarian stimulation in the small ovarian reserve heifer (SORH) cause premature cumulus expansion and follicular hyperstimulation dysgenesis (FHD) in nearly all ovulatory-size follicles with predicted disruptions i...
'Human and Animal Model Reproductive Epigenetics' special collection: (un)intended marks on fertility [0.03%]
《人类和动物模型生殖表观遗传学》特刊：(非)有意留下的生育标记
Michele Boiani,Francesca E Duncan
Michele Boiani
Treatment with cholesterol just after thawing maintains the fertility of bull sperm [0.03%]
解冻后立即添加胆固醇可保持公牛精子的受精能力
Md Mazharul Islam,Takashi Umehara,Natsumi Tsujita et al.
Md Mazharul Islam et al.
Freezing and thawing diminish sperm motility and fertility by disrupting the cholesterol balance in sperm plasma and organelle membranes. The aim of this study was to elucidate the mechanisms through which exogeneous cholesterol treatment e...
Maternal age and gonadotrophin elevation cooperatively decrease viable ovulated oocytes and increase ootoxicity, chromosome-, and spindle-misalignments: '2-Hit' and 'FSH-OoToxicity' mechanisms as new reproductive aging hypotheses [0.03%]
高龄和促性腺激素升高协同减少有效排卵卵子，并增加卵毒性、染色体错位和纺锤体错位：“两击”假说及“FSH-卵毒性”机制作为新的生殖衰老假说
Lori R Bernstein,Amelia C L Mackenzie,Keith Durkin et al.
Lori R Bernstein et al.
While there is consensus that advanced maternal age (AMA) reduces oocyte yield and quality, the notion that high FSH reduces oocyte quality and causes aneuploidy remains controversial, perhaps due to difficulties controlling the confounding...
TRPV2, a novel player in the human ovary and human granulosa cells [0.03%]
瞬时受体电位香草素子通道V2是人卵巢及颗粒细胞的新成员
Katja Eubler,Karolina M Caban,Gregory A Dissen et al.
Katja Eubler et al.
The cation channel 'transient receptor potential vanilloid 2' (TRPV2) is activated by a broad spectrum of stimuli, including mechanical stretch, endogenous and exogenous chemical compounds, hormones, growth factors, reactive oxygen species,...