Difelikefalin-associated adverse drug event signals: a real-world pharmacovigilance study from the FAERS database [0.03%]
基于FAERS数据库的迪拉非兰相关不良事件信号的药物警戒研究
Jinshan Zhao,Quanyu Qiu,Jidong Zhang et al.
Jinshan Zhao et al.
Background and objective: Difelikefalin, a peripherally acting selective κ-opioid receptor agonist, is approved for treating chronic kidney disease-associated pruritus (CKD-aP) in adults on hemodialysis. However, real-wo...
Becky Mingyao Ma,Shirley Pik Ying Hue,Wei Ma et al.
Becky Mingyao Ma et al.
Background: A significant proportion of patients present with chronic kidney disease of unexplained cause (CKDx) despite standard-of-care diagnostic workup. Data from Australian, European and United States cohorts show th...
Sex disparities in receiving evidence-based medications in patients with CKD [0.03%]
慢性肾脏病患者接受循证药物治疗的性别差异
Rui Du,Hannah Wallace,Jeffrey T Ha et al.
Rui Du et al.
Background and hypothesis: Chronic kidney disease (CKD) is a growing global health burden. While studies have demonstrated sex disparities in CKD prevalence and outcomes, evidence on sex-based differences in therapeutic m...
Klotho suppresses cyst growth in ADPKD through the regulation of ferroptosis and reversing DNA methylation [0.03%]
克洛托通过调节铁死亡和逆转DNA甲基化抑制ADPKD囊肿生长
Jiayi Lv,Cheng Xue,Linda Xiaoyan Li et al.
Jiayi Lv et al.
Background: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst growth, inflammation, fibrosis, and renal failure. Klotho is a renoprotective protein with anti-proliferative, anti-inf...
GLP-1 receptor agonists in patients with Type 2 diabetes: cardiorenal protection versus ocular safety [0.03%]
GLP-1受体激动剂在2型糖尿病患者中的应用：心血管肾脏保护与眼部安全性的权衡
Elisabeth Buur Stougaard,Peter Rossing
Elisabeth Buur Stougaard
Beyza Nur Kahraman Kızılcaoluk,Seda Pehlivan
Beyza Nur Kahraman Kızılcaoluk
Luigi Cirillo,Samantha Innocenti,Glenda Cancila et al.
Luigi Cirillo et al.
FINE-ONE, more to come: moving beyond ACEis and ARBs in type 1 diabetes with kidney disease? [0.03%]
FINE-ONE，更多值得期待的内容：1型糖尿病肾病的治疗超越ACEi和ARB？
Marieta Theodorakopoulou,William P Martin,Sebastjan Bevc et al.
Marieta Theodorakopoulou et al.