Effect of pre-vaccination blood and T-cell phenotypes on antibody responses to COVID-19 mRNA vaccine [0.03%]
接种COVID-19 mRNA疫苗前的血液和T细胞表型对抗体反应的影响
Yu Hidaka,Norihide Jo,Osamu Kikuchi et al.
Yu Hidaka et al.
Despite the high effectiveness of the coronavirus disease (COVID-19) mRNA vaccines, both immunogenicity and reactogenicity show substantial interindividual variability. One key challenge is predicting high and low responders using easily me...
Roles of fibroblasts in the pathogenesis of inflammatory bowel diseases (IBDs) and IBD-associated fibrosis [0.03%]
成纤维细胞在炎症性肠病及其相关纤维化发病机制中的作用
Takayoshi Ito,Hisako Kayama
Takayoshi Ito
Ulcerative colitis and Crohn's disease, the principal forms of inflammatory bowel disease (IBD), are chronic relapsing inflammatory disorders of the gastrointestinal tract. The incidence and prevalence of IBD have been increasing worldwide,...
B10 cells promote pro-resolving macrophage function through direct cell-cell contact and IL-10 secretion in Raw 264.7 cells [0.03%]
B10细胞通过直接的细胞接触和在Raw 264.7细胞中分泌IL-10来促进促解决型巨噬细胞的功能
Takumi Memida,Elaheh Dalir Abdolahinia,Guoqin Cao et al.
Takumi Memida et al.
It is well known that regulatory B cells (Breg), especially IL-10-producing regulatory cells (B10), play an important role in immune regulation during inflammatory and infectious diseases. Although it has been revealed that the immune regul...
Kazumasa Suzuki,Anjana Rao,Atsushi Onodera
Kazumasa Suzuki
Ten-eleven translocation (TET) proteins are dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). All three epigenetic modi...
Correlation of Interferons and Autoimmune Aspects in Long COVID-19 Patients [0.03%]
长新冠患者的干扰素和自身免疫特征之间的关联分析
Fumiyuki Hattori,Junji Nishiyama,Hideaki Hasuo
Fumiyuki Hattori
Long COVID, or post-acute sequelae of COVID-19 (PASC), represents a major global health challenge, with its underlying mechanisms remaining poorly understood despite substantial research and clinical trials. This study investigates the role...
CD20 and CD19 promote proliferation driven by the IgM-TLR9-L265P MyD88 complex [0.03%]
CD20和CD19通过IgM-TLR9-L265P MyD88复合体促进增殖作用
Yohei Kobayashi,Ryota Sato,Yuri Shimizu et al.
Yohei Kobayashi et al.
The cancer driver mutation L265P MyD88 is found in approximately 30 % of cases in the activated B cell-like subgroup of diffuse large B cell-like lymphoma (ABC DLBCL). L265P MyD88 forms a complex with TLR9 and IgM, referred to as the My-T-B...
TLR7 responses in glomerular macrophages accelerate the progression of glomerulonephritis in NZBWF1 mice [0.03%]
NZBWF1鼠系肾小球系膜细胞的TLR7反应加速了肾小球肾炎的发展
Reika Tanaka,Yusuke Murakami,Dorothy Ellis et al.
Reika Tanaka et al.
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the production of autoantibodies and damage to multiple organs. Glomerulonephritis, a manifestation involving glomerular deposition of immune complexes and...
Beneficial effects on T cells by photodynamic therapy with talaporfin enhance cancer immunotherapy [0.03%]
利用太泊芬光动力疗法增强T细胞的免疫治疗作用
Ehab M Ezzaldeen,Tomonori Yaguchi,Ryotaro Imagawa et al.
Ehab M Ezzaldeen et al.
Photodynamic therapy (PDT), a local cancer treatment using photosensitizers, has been reported to enhance antitumor immune responses by inducing immunogenic cell death. Although several studies have demonstrated the synergistic antitumor ef...
Hiroaki Ikeda
Hiroaki Ikeda
Since the first approval of an immune-checkpoint inhibitor, we have witnessed the clinical success of cancer immunotherapy. Adoptive T-cell therapy with chimeric antigen-receptor T (CAR-T) cells has shown remarkable efficacy in hematologica...
Intestinal Foxl1+ cell-derived CXCL12 maintains epithelial homeostasis by modulating cellular metabolism [0.03%]
肠Foxl1+细胞衍生的CXCL12通过调节细胞代谢维持上皮稳态
Mayu Yagita-Sakamaki,Takayoshi Ito,Taiki Sakaguchi et al.
Mayu Yagita-Sakamaki et al.
Several mesenchymal cell populations are known to regulate intestinal stem cell (ISC) self-renewal and differentiation. However, the influences of signaling mediators derived from mesenchymal cells other than ISC niche factors on epithelial...