TLR7 responses to nucleosides drive sialadenitis in Slc29a3-deficient mice [0.03%]
Slc29a3缺陷小鼠中对核苷的TLR7应答驱动唾液腺炎发生
Takuma Shibata,Kotono Okabe-Kibe,Hu Chen et al.
Takuma Shibata et al.
Autoimmune sialadenitis is a hallmark of IgG4-related disease (IgG4-RD) and Sjögren syndrome (SS). The single-stranded RNA sensor TLR7 has been shown as a driver of sialadenitis. Although TLR7 is activated by ssRNA degradation products suc...
Generation of CD68+ macrophage-depleted NOG mice for in vivo engraftment of human red blood cells [0.03%]
用于人红细胞植入的CD68阳性巨噬细胞耗竭NOG小鼠的制备
Yusuke Ohno,Misa Mochizuki,Kenji Kawai et al.
Yusuke Ohno et al.
Humanized mice are invaluable models for investigating human cell engraftment in vivo post-transplantation. Mice engrafted with human red blood cells (hRBCs) are useful for examining the physiological roles of hRBCs in vivo, including studi...
Brooke E Towers,Gregory F Sonnenberg
Brooke E Towers
The human gastrointestinal tract is a unique mucosal barrier with a tremendous surface area that is subject to continuous exposure to the environment. The immune system must remain poised to protect this organ system from potential pathogen...
Repetitive Fasting-Refeeding Enhances Metformin-Induced CXCR6+ CD8+T Cell Tumor Infiltration via VCAM-1 Upregulation on Normalized Vasculature During Refeeding [0.03%]
周期性禁食复食通过正常化血管上VCAM-1的上调增强甲福明诱导的CXCR6⁺CD8⁺T细胞向肿瘤浸润
Weiyang Zhao,Miho Tokumasu,Mikako Nishida et al.
Weiyang Zhao et al.
Fasting is known to alter the circulation dynamics of immune cells, including T cells, by shifting them from peripheral tissues to the bone marrow (BM), where they enter a quiescent state to avoid starvation stress and acquire apoptosis res...
TACI is required for the survival of short- and long-lived plasma cells [0.03%]
TACI对于短寿命和长寿命浆细胞的生存是必需的
Kenji Funakoshi,Takuya Koike,Wataru Ise et al.
Kenji Funakoshi et al.
In a typical immune response, naïve B cells are activated, differentiate into short-lived plasma cells (SLPCs), and then mature into long-lived plasma cells (LLPCs) in the bone marrow. Among three TNF family receptors (BAFF-R, TACI, and BC...
Alcaligenes lipid A as a sublingual adjuvant to augment protective immune responses in the respiratory and gastrointestinal tracts [0.03%]
辅以脂多糖佐剂增强呼吸道和胃肠道保护性免疫反应
Ken Yoshii,Zilai Liu,Atsushi Shimoyama et al.
Ken Yoshii et al.
We previously identified Alcaligenes as symbiotic bacteria residing within Peyer's patches and demonstrated that their primary components, lipopolysaccharides, and their active center, lipid A, are excellent adjuvants for mucosal vaccinatio...
Correction to: Single-cell multiomic analysis revealed the differentiation, localization, and heterogeneity of IL10+ Foxp3- follicular T cells in humans [0.03%]
Correction to：单细胞多组学分析揭示了人类中IL10+Foxp3-滤泡性T细胞的分化、定位和异质性
Published Erratum
International immunology. 2025 Nov 11:dxaf059. DOI:10.1093/intimm/dxaf059 2025
KRAS mutations disrupt interactions between CD8+ T cells and antigen-presenting cells in the tumor microenvironment of biliary tract cancer [0.03%]
KRAS突变破坏胆道癌肿瘤微环境中CD8+T细胞和抗原呈递细胞的相互作用
Fumihiro Terasaki,Shogo Kumagai,Akito Fukuda et al.
Fumihiro Terasaki et al.
Biliary tract cancer (BTC) exhibits a poor prognosis and limited responses to current therapeutic strategies. While surgical resection followed by adjuvant S-1 therapy is the standard curative treatment for BTC, long-term postoperative remi...
mTORC1-Independent IgA Production: A Unique Pathway for Gut Immune Homeostasis [0.03%]
无需mTORC1的IgA产生：肠道免疫稳态的独特途径
Masashi Ohtani,Hideki Fujii,Takashi Watanabe et al.
Masashi Ohtani et al.
The mammalian target of rapamycin (mTOR) complex 1 (mTORC1) regulates various cellular processes, including immune responses. Previous studies have demonstrated that mTORC1 plays a crucial for B cell differentiation and the production of Ig...