Toshiya Hino,Yusuke Ito,Yuki Kagoya
Toshiya Hino
Bispecific antibodies (BsAbs) are emerging immunotherapeutics that simultaneously engage two distinct targets. This property provides unique mechanisms of action that are not achieved by conventional monoclonal antibodies, including cell-ce...
David Frieser,Noemie Gensous,Victor Appay
David Frieser
Recent pandemics, the increasing incidence of cancer and an inversion of the age pyramid towards an older society fuels the need for an in depth understanding of the field of inflammaging and changes in the immune system, in particular of t...
Innate immune responses underlying local and systemic adverse reactions to mRNA-lipid nanoparticle vaccines [0.03%]
基于脂质纳米颗粒的mRNA疫苗引起的局部和全身不良反应的先天免疫应答机制研究
Tomohiro Takano,Takayuki Matsumura,Yoshimasa Takahashi
Tomohiro Takano
Vaccine reactogenicity refers to the capacity of a vaccine to induce transient local and systemic adverse reactions (ARs). Although these ARs are often attributed to vaccine-induced innate inflammation, accumulating evidence indicates that ...
Emergence and divergence of blood cell lineages in the history of animal evolution [0.03%]
动物进化史上血细胞系的产生和分化
Yosuke Nagahata,Hiroshi Kawamoto
Yosuke Nagahata
Humans possess various blood cell types, such as T cells, B cells, monocytes/macrophages, neutrophils, dendritic cells, erythrocytes, and platelets/thrombocytes, and these lineages are shared by nearly all vertebrates. Although invertebrate...
Th1-Adapted Regulatory T Cells in Tumor Immunity and Inflammatory Diseases [0.03%]
适应Th1细胞的调节性T细胞在肿瘤免疫和炎症性疾病中的作用
Ayumi Kuratani,Masaaki Okamoto,Takashi Kobayashi et al.
Ayumi Kuratani et al.
Regulatory T cells (Tregs) play an essential role in maintaining immune tolerance and controlling excessive inflammation. Although traditionally viewed as a stable lineage dedicated to broad immunosuppression, accumulating evidence has reve...
Cytotoxic CD4+ T cells across aging: a conceptual framework for health, protection, pathology, and age-associated diseases [0.03%]
细胞衰老背景下具有细胞毒性的CD4+T细胞：对健康、保护、病理及与年龄相关的疾病的概念性框架
Tatsuya Hasegawa,Kosei Nishitani,Kenji Kabashima
Tatsuya Hasegawa
Aging is the primary risk factor for a wide spectrum of chronic diseases, ranging from infectious diseases and cancer to autoimmunity and neurodegeneration. One of the key drivers of this increased susceptibility is the progressive decline ...
The CCL20-CCR6 axis predominantly drives IL-17-mediated psoriasis while modestly contributing to papain-induced type 2 inflammation [0.03%]
CCL20-CCR6轴主要驱动IL-17介导的银屑病，而对木瓜蛋白酶诱导的2型炎症有适度贡献
Supanuch Ekronarongchai,Nozomi Sachi,Yomei Kagoshima et al.
Supanuch Ekronarongchai et al.
Chronic inflammatory skin diseases such as psoriasis and atopic dermatitis (AD) are characterized by immune dysregulation. The chemokine CCL20 and its unique receptor CCR6 are upregulated in lesional skin of patients with both psoriasis and...
Transiently produced IgGs enable infection-blocking vaccine efficacy assessment [0.03%]
瞬时产生的IgG使人们能够评估具有阻断感染作用的疫苗效力
Jingzhi Li,Chaoyi Gu,Xiaochun Chen et al.
Jingzhi Li et al.
Many vaccines are evaluated based on their ability to prevent symptoms, rather than infection itself, limiting their effectiveness in controlling asymptomatic transmission and achieving viral eradication. Here, we aimed to develop a serolog...
Noriko Shinjyo,Masahiko Shigemura,Yasutaka Okabe
Noriko Shinjyo
Respiratory infections remain a major threat to global health. To counter these insults, the respiratory system has evolved multilayered defense strategies that integrate anatomical and mechanical barriers with both innate and adaptive immu...