RNF213-TRAF2 interaction enhances inflammatory responses via NF-κB activation in moyamoya disease [0.03%]
RNF213-TRAF2相互作用通过NF-κB激活增强 Moyamoya病的炎症反应
Mitsutaka Yasuda,Kaoru Murakami,Jing-Jing Jiang et al.
Mitsutaka Yasuda et al.
Moyamoya disease (MMD) is a cerebrovascular disorder that predominantly affects East Asian populations. It is characterized by progressive stenosis or occlusion of terminal internal carotid arteries. Although inflammatory and autoimmune res...
ELAVL1 modulates periodontal ligament fibroblast pyroptosis in periodontitis through the JAK2/STAT3/NLRP3 axis [0.03%]
ELAVL1通过JAK2/STAT3/NLRP3轴调节牙周病中的牙周韧带成纤维细胞焦亡
Huayong Zhan,Ge Shi,Qin Xie et al.
Huayong Zhan et al.
Periodontitis is an inflammatory disorder that leads to the destruction of periodontal tissues. Pyroptosis, related to the NLRP3 inflammasome, is implicated in the pathogenesis of periodontitis. ELAVL1, an m6A reader, is associated with inf...
Overexpression of the transcriptional corepressor Tle1 enhances effector proliferation of CD8+ T cells during acute and chronic viral infections [0.03%]
转录共抑制因子Tle1的过表达可增强CD8⁺T细胞在急性期和慢性期病毒感染过程中的效应增殖能力
Ryotaro Shiga,Sotaro Fujisawa,Yamato Tanabe et al.
Ryotaro Shiga et al.
The transcriptional corepressor Tle (transducin-like enhancer of split) proteins interact with transcription factors such as TCF-1 and Runx3 to regulate transcriptional programmes during cellular development and differentiation; however, th...
Yudai Hirano,Yoshihiko Tomofuji,Ryuya Edahiro et al.
Yudai Hirano et al.
The gut microbiome has emerged as an important environmental factor in the pathogenesis of autoimmune diseases. Advances in high-throughput sequencing technologies have enabled comprehensive characterization of the gut microbiome, providing...
Single-cell RNA-sequencing of myasthenia gravis reveals transcriptional heterogeneity and dysfunction of immune cell populations [0.03%]
单细胞RNA测序揭示重症肌无力中免疫细胞群的转录异质性和功能障碍
Qingjun Wu,Yingyu Guo,Liying Zhou et al.
Qingjun Wu et al.
The purpose of this study was to explore the composition and function of immune cell subsets at the single cell level in thymus and peripheral blood of patients with myasthenia gravis (MG). A total of 9701 and 23846 cells respectively origi...
Transduction of Batf family members provides distinct functions to mouse CD8+ T cells [0.03%]
BATF家族成员的转导赋予小鼠CD8⁺T细胞不同的功能
Kenta Kondo,Mina Kumode,Hiroki Satooka et al.
Kenta Kondo et al.
Members of the Batf family, including Batf, Batf2, and Batf3, play critical roles in various immune cell types. Several studies have suggested redundant functions, as they can compensate for each other's functions. Here, we show that transd...
Epitope specificity shapes the CD4+ T cell response to influenza virus infection in mice [0.03%]
流感病毒表位特异性塑造小鼠CD4+t细胞免疫反应
Daiki Mori,Nicolas Sax,Nozomi Shimada et al.
Daiki Mori et al.
Helper CD4+ T cells play a central role in orchestrating protective immune responses during infection and vaccination. Activation of naïve CD4+ T cells is initiated by the recognition of antigenic peptides presented on MHC class II molecul...
David Priest,James Wing
David Priest
In human blood B cells exist in a variety of forms ranging from antigen inexperienced naive cells to long term memory cells, and antibody producing plasma cells. Historically the divisions between these types of cells have been defined by a...
Identification and characterization of CXCL13 producers in bone tissue in response to fasting [0.03%]
饥饿对骨组织CXCL13生成细胞的鉴定与表征
Takuma Okawa,Motoyoshi Nagai,Shinya Fujita et al.
Takuma Okawa et al.
The bone tissue serves as a dynamic reservoir that accommodates diverse immune cell populations during low-energy states such as fasting. Energy-restriction and reduced metabolism induce a transient migration of naïve B cells from Peyer's ...
Repeated mRNA vaccination and breakthrough infection reveal durable dominance but diminishing recall of vaccine-induced CD8⁺ T-cell clones [0.03%]
重复的mRNA疫苗接种和突破性感染揭示了疫苗诱导的CD8⁺T细胞克隆持久的主导地位但回忆作用减弱
Peng Xu,Satoshi Ueha,Hiroyasu Aoki et al.
Peng Xu et al.
Successive mRNA vaccinations preserve SARS-CoV-2-specific T-cell immunity, but how individual CD8⁺ T-cell clones behave across repeated booster doses and breakthrough infection (BTI) remains poorly defined. We longitudinally tracked bulk C...