Thymic cortical epithelial Psmb11-encoded β5t in mouse and human [0.03%]
小鼠和人的胸腺皮质上皮细胞系源性Psmb11编码的β5t蛋白
Mei-Ting Yang,Akihide Shimizu,Mami Matsuda-Lennikov et al.
Mei-Ting Yang et al.
Psmb11-encoded β5t is a proteolytic subunit of thymoproteasomes expressed in cortical thymic epithelial cells (cTECs). β5t-containing thymoproteasomes are essential for the thymic generation of CD8-lineage cytotoxic T cells. Here, we outl...
Ichiro Taniuchi
Ichiro Taniuchi
This review summarizes key topics discussed in the session "Biology within the Thymus" at the 54th Annual Meeting of the Japanese Society for Immunology, which highlighted recent advances in our understanding of T-cell development and fate ...
17,18-epoxyeicosatetraenoic acid and its metabolite attenuate IL-33-induced airway inflammation involving group 2 innate lymphoid cells [0.03%]
17,18-环氧二十碳四烯酸及其代谢产物通过作用于2型固有淋巴样细胞抑制IL-33诱导的气道炎症反应
Ichiro Tojima,Tatsuji Nishiguchi,Kento Kawakita et al.
Ichiro Tojima et al.
Group 2 innate lymphoid cells (ILC2s) play critical roles in type 2 airway inflammation. 17,18-epoxyeicosatetraenoic acid (17,18-EpETE), an eicosapentaenoic acid metabolite, is generated from dietary omega-3 fatty acids, and may have anti-i...
FcμR enhances recall responses by promoting the generation of CD80+PD-L2+ memory B cells [0.03%]
FcμR通过促进生成CD80+PD-L2+记忆B细胞来增强回忆反应
Runyun Zhang,Jiping Sun,Lulu Dong et al.
Runyun Zhang et al.
The IgM Fc receptor (FcμR), the sole receptor specific for IgM, is crucial for B cell survival and humoral immunity. Yet, its role in memory B cells (MBCs) has remained unclear. Here, we show that FcμR-/- mice immunized with the T-depende...
Mitochondrial Transfer-Driven Immune Evasion in the Tumor Microenvironment [0.03%]
肿瘤微环境中的线粒体转移驱动的免疫逃逸
Li Zhu,Yosuke Togashi
Li Zhu
The tumor microenvironment (TME) is a complex landscape where metabolic interactions significantly dictate antitumor immunity. Immune evasion in cancer is typically discussed in terms of inhibitory receptors and ligands, suppressive cytokin...
Granulocyte heterogeneity in immune-mediated and inflammatory diseases: Insights from single-cell transcriptomic analyses [0.03%]
免疫介导和炎症性疾病中粒细胞异质性：单细胞转录组分析的新见解
Hiroshi Shimagami,Atsushi Kumanogoh,Masayuki Nishide
Hiroshi Shimagami
Neutrophils and eosinophils have long been regarded as terminal effectors of innate immunity. Technical advances in single-cell RNA sequencing define transcriptome-based granulocyte subsets beyond classical density- and surface marker-based...
Beyond B cell helpers: diverse roles of peripheral helper T cells [0.03%]
超越B细胞辅助功能：外周-helper-T细胞的多样角色
Yuki Masuo,Hiroyuki Yoshitomi
Yuki Masuo
Peripheral helper T cells (TPH cells) constitute a subset of CD4+ T cells that provide help to B cells in inflamed non-lymphoid tissues. TPH cells have been identified across various chronic disorders, especially autoimmune diseases, and ac...
Mari Murakami,Kiyoshi Takeda
Mari Murakami
The intestine is continuously exposed to diverse microbial, dietary, and environmental signals, requiring tightly regulated immune responses that balance host defense and tolerance. Recent advances in single-cell and multiomic technologies ...
Alarmin cues and regulated cell death calibrate mucosal immunoglobulin A responses and virologic control after intranasal whole-virion inactivated influenza vaccination [0.03%]
胞壁肽和受调节的细胞死亡校准黏膜免疫球蛋白A反应及鼻内灭活全病毒流感疫苗接种后的病毒控制水平
Eita Sasaki,Hideki Asanuma,Yoshimasa Takahashi et al.
Eita Sasaki et al.
How tissue damage cues and regulated cell death programs instruct antigen-specific mucosal IgA after vaccination remains incompletely defined. Using a mouse model of intranasal whole-virion inactivated influenza vaccination, we identify two...
The IL-10/IL-10Rα axis in fibroblasts limits large intestinal pathology by suppressing type I interferon signaling [0.03%]
成纤维细胞中 IL-10/IL-10Rα 轴通过抑制 1 型干扰素信号限制大肠病理变化
Takayoshi Ito,Bo Li,Taiki Sakaguchi et al.
Takayoshi Ito et al.
Recent studies identified that the dysregulation of fibroblast activity, in addition to impairment in epithelial integrity and uncontrolled immune response, is implicated in the pathogenesis of inflammatory bowel disease (IBD). The anti-inf...