Intra-tumoral delivery of 5'ppp-dsRNA induces a robust antitumor response via RIG-I activation and Bcl-2 gene downregulation in a murine model of prostate cancer [0.03%]
携带5'ppp-dsRNA的肿瘤内给药通过RIG-I活化和Bcl-2基因下调在前列腺癌小鼠模型中诱导强大的抗肿瘤反应
Kasturi Ganguly,Siddhanath M Metkari,Barnali Biswas et al.
Kasturi Ganguly et al.
Onco-immunotherapy via blocking checkpoint inhibitors has revolutionized the treatment-landscape of several malignancies, though not in the metastatic castration-resistant prostate cancer (PCa) owing to an immunosuppressive and poorly immun...
An abnormal increase in CD26(-)CD28(-) cytotoxic effector CD4 and CD8 T cell populations in patients with systemic lupus erythematosus [0.03%]
系统性红斑狼疮患者中CD26negCD28neg细胞毒性效应CD4和CD8T细胞群的异常增加
Ryo Hatano,Hayato Nakamura,Ayako Yamamoto et al.
Ryo Hatano et al.
CD26 is a human T cell costimulatory molecule as well as a T cell subset marker, and increase of CD26+ T cells in inflamed tissues and peripheral blood has been reported in diverse autoimmune diseases. In contrast, our group has previously ...
Yuji Fukushima,Ryuji Ueno,Nagahiro Minato et al.
Yuji Fukushima et al.
Age-related changes in the immune system, referred to as immunosenescence, appear to evolve with rather paradoxical manifestations, a diminished adaptive immune capacity, and an increased propensity for chronic inflammation often with autoi...
Xin Tang,Mei Li
Xin Tang
Atopic diseases, including atopic dermatitis (AD), food allergy (FA), asthma, and allergic rhinitis (AR) are closely related to inflammatory diseases involving different body sites (i.e. the skin, airway, and digestive tract) with character...
Mechanisms and Effects of Activation of Innate Immunity by Mitochondrial Nucleic Acids [0.03%]
线粒体核酸激活固有免疫的机制和效应
Prashant Rai,Michael B Fessler
Prashant Rai
In recent years, a growing number of roles have been identified for mitochondria in innate immunity. One principal mechanism is that translocation of mitochondrial nucleic acid species from the mitochondrial matrix to the cytosol and endoly...
Yu Miyamoto,Masaru Ishii
Yu Miyamoto
The immune system exhibits spatial diversity in in vivo tissues. Immune cells are strategically distributed within tissues to maintain the organ integrity. Advanced technologies such as intravital imaging and spatial transcriptomics have re...
The role of dendritic cells in the instruction of helper T cells in the allergic march [0.03%]
树突细胞在辅助性T细胞向过敏行进过程中指导作用的影响
Masato Kubo,Yasuyo Harada,Takanori Sasaki
Masato Kubo
Allergy is a complex array of diseases influenced by innate and adaptive immunity, genetic polymorphisms, and environmental triggers. Atopic dermatitis is a chronic inflammatory skin disease characterized by barrier defects and immune dysre...
A splice of life: the discovery, function, and clinical implications of FOXP3 isoforms in autoimmune disease [0.03%]
FOXP3异构体的发现、功能及其在自身免疫病中的临床意义
Kristin N Weinstein,Phillip P Domeier,Steven F Ziegler
Kristin N Weinstein
Regulatory T cells (Tregs) are a specialized subset of CD4+ T cells essential for the maintenance of immune homeostasis and prevention of autoimmunity. Treg lineage and functions are programmed by the X-chromosome encoded transcription fact...
The active form of vitamin D (calcitriol) promotes CXCR5 expression during follicular helper T cell differentiation [0.03%]
活性形式的维生素D（ calcitriol）通过促进滤泡辅助T细胞分化过程中的CXCR5表达发挥作用
Makoto Iwata,Ayumi Takada,Rei Sakamoto et al.
Makoto Iwata et al.
Follicular helper T (Tfh) cells promote B cell differentiation and antibody production in the B cell follicles of secondary lymphoid organs. Tfh cells express their signature transcription factor BCL6, interleukin (IL)-21, and surface molec...
Pathogenesis of IgA nephropathy as a tissue-specific autoimmune disease [0.03%]
IgA肾病作为组织特异性自身免疫性疾病的发病机制
Yoshihito Nihei,Daisuke Kitamura
Yoshihito Nihei
Glomerulonephritis (GN) is a group of heterogeneous immune-mediated kidney diseases that causes inflammation within the glomerulus. Autoantibodies (auto-Abs) are considered to be central effectors in the pathogenesis of several types of GN....