Increased serum IgG antibody response to Merkel cell polyomavirus oncoproteins in patients with autoimmune rheumatic diseases [0.03%]
自身免疫性风湿病患者中默克尔细胞多瘤病毒癌蛋白的血清IgG抗体反应增强
Chiara Mazziotta,Giulia Tonnini,Milena Oimo et al.
Chiara Mazziotta et al.
Autoimmune rheumatic diseases (AIRDs) encompass a spectrum of disorders with a partially understood pathogenesis. A role for polyomaviruses in AIRDs occurrence has been reported. However, the involvement of Merkel cell polyomavirus (MCPyV),...
Less severe tumor growth in mice in which mgmt is conditionally deleted using the LysM-Cre system, and the possible impacts of DNA methylation in tumor-associated macrophages [0.03%]
利用LysM-Cre系统在小鼠中条件性删除MGMT后肿瘤生长减缓以及肿瘤相关巨噬细胞中DNA甲基化可能产生的影响
Pornpimol Phuengmaung,Wilasinee Saisorn,Atsadang Boonmee et al.
Pornpimol Phuengmaung et al.
Despite the importance of O6-methylguanine-DNA methyltransferase (MGMT) (a DNA repair enzyme) in cancer cells, MGMT impacts in macrophages are still unknown. In mgmt null mice (mgmtflox/flox; LysM-Crecre/-; mgmt deletion only in macrophages...
Antigen-presenting cells and lung CD8⁺ resident memory T cells coordinate local immune protection and shape responses to respiratory virus infection [0.03%]
抗原呈递细胞和肺驻留记忆CD8⁺T细胞协调局部免疫防御并塑造对呼吸道病毒的反应
Takumi Kawasaki,Moe Ikegawa,Taro Kawai
Takumi Kawasaki
The respiratory mucosa, encompassing the lungs and nasal tissues, serves as the primary barrier against respiratory viruses. While neutralizing antibodies are effective at preventing viral entry, virus-specific CD8⁺ T cells play a vital ro...
Toshio Kanno,Keiko Nakano,Yusuke Endo
Toshio Kanno
CD4+ helper T (Th) cell subsets play an essential role in the regulation of adaptive immunity. Th9, Th17, and regulatory T (Treg) cells require transforming growth factor-beta (TGF-β) for their differentiation; however, their respective fu...
Modulating Dendritic Cell function in Allergic Asthma with Toxoplasma gondii serine-protease inhibitor 1 [0.03%]
用弓形虫丝氨酸蛋白酶抑制因子1调节过敏性哮喘小胶质细胞的功能
Joel Katan Piñeiro,Ariadna Soledad Soto,Ana Farias et al.
Joel Katan Piñeiro et al.
Tolerogenic adjuvants can enhance allergy vaccine efficacy. We previously showed that intranasal administration of recombinant Toxoplasma gondii serine protease inhibitor 1 (rTgPI-1) with ovalbumin alleviates asthma symptoms in mice. This s...
The Arf pathway is required for resolving ER stress during T cell activation [0.03%]
Arf通路在T细胞活化过程中应对内质网应激所必需
Mami Sumiyoshi,Yui Kotani,Chikako Shimokawa et al.
Mami Sumiyoshi et al.
Upon antigen recognition, T cells undergo rapid cell proliferation and differentiation, which is accompanied by a drastic change in cellular metabolism. The ADP-ribosylation factor (Arf) pathway contributes to cellular homeostasis by orches...
SLAMF6 regulates basal T cell receptor signaling and influences invariant natural killer T cell lineage diversity [0.03%]
SLAMF6调节基础性T细胞受体信号并影响不变自然杀伤T细胞系多样性
Yukihiro Endo,Ichita Hasegawa,Akemi Igi et al.
Yukihiro Endo et al.
Invariant natural killer T (iNKT) cells differentiate into at least three distinct subsets within the thymus, with each subset's frequency varying considerably among mouse strains; however, the molecular mechanisms involved remain unclear. ...
TLR7 responses in glomerular macrophages accelerate the progression of glomerulonephritis in NZBWF1 mice [0.03%]
TLR7应答加速NZBWF1鼠系肾小球肾炎进展
Reika Tanaka,Yusuke Murakami,Dorothy Ellis et al.
Reika Tanaka et al.
Systemic lupus erythematosus is a systemic autoimmune disease characterized by the production of autoantibodies and damage to multiple organs. Glomerulonephritis, a manifestation involving glomerular deposition of immune complexes and compl...
The impact of Talin2, a signaling protein regulating the focal adhesion complex, on asthma [0.03%]
衔接蛋白Talin2调控细胞黏着斑信号转导对哮喘的影响作用研究
Da Yeon Hwang,Min-Hyeok An,Pureun-Haneul Lee et al.
Da Yeon Hwang et al.
Talin protein as a mechanosensitive cytoskeleton protein connect the extracellular matrix to the cytoskeleton by linking to integrins and actin, thereby mediating the conversion of mechanical signals into biochemical signals and influencing...
Secreted phospholipase A2 regulates intercellular communications by coordinating extracellular phospholipid metabolism [0.03%]
分泌型磷脂酶A2通过协调细胞外磷脂代谢调节细胞间通讯
Makoto Murakami
Makoto Murakami
Lipids play fundamental roles in life. In essence, "phospholipase A2" (PLA2) indicates a group of enzymes that release fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids. To date, more than 50 enzymes...