Intestinal Foxl1+ cell-derived CXCL12 maintains epithelial homeostasis by modulating cellular metabolism [0.03%]
肠Foxl1+细胞衍生的CXCL12通过调节细胞代谢维持上皮稳态
Mayu Yagita-Sakamaki,Takayoshi Ito,Taiki Sakaguchi et al.
Mayu Yagita-Sakamaki et al.
Several mesenchymal cell populations are known to regulate intestinal stem cell (ISC) self-renewal and differentiation. However, the influences of signaling mediators derived from mesenchymal cells other than ISC niche factors on epithelial...
A complex of NLRP3 with caspase-4 is essential for inflammasome activation by Tannerella forsythia infection [0.03%]
牙龈卟啉单胞菌感染通过NLRP3与caspase-4的复合物激活炎性小体
Chen Wei Hsu,Tokuju Okano,Yuiko Niinuma et al.
Chen Wei Hsu et al.
Periodontitis, a chronic inflammatory disease of periodontal tissue, is often associated with a group of pathogenic bacteria known as the "red complex," including Tannerella forsythia (T. forsythia). Previous papers showed that T. forsythia...
Analysis of antigen specificity of Treg cell clonotypes expanded upon SARS-CoV-2 infection [0.03%]
分析Treg细胞克隆型在感染SARS-CoV-2后的抗原特异性
Yukiko Takeuchi,Eri Ishikawa,Takashi Sato et al.
Yukiko Takeuchi et al.
The pandemic outbreak of SARS-CoV-2 has threatened human health worldwide. Among protective immune reactions, T cell responses are diverse among individuals, which is related to the differences in severity. A T cell subset, regulatory T (Tr...
IL-5-producing group 2 innate lymphoid cells promote T cell-independent IgA production in cooperation with eosinophils [0.03%]
II型固有淋巴样细胞通过与嗜酸性粒细胞相互作用促进IgA的产生且不依赖于T细胞
Tsutomu Yanagibashi,Masashi Ikutani,Terumi Nagai et al.
Tsutomu Yanagibashi et al.
Intestinal bacteria play a critical role in the regulation of the host immune system and an imbalance in intestinal bacterial composition induces various host diseases. Therefore, maintaining a balance in the intestinal bacterial compositio...
Yasuhiro Kato,Atsushi Kumanogoh
Yasuhiro Kato
Immune memory has long been considered a function specific to adaptive immune systems; however, adaptive immune memory alone has not fully explained the mechanism by which vaccines exert their protective effects against non-target pathogens...
The role of polyreactive memory B cells in systemic lupus erythematosus [0.03%]
多反应性记忆B细胞在系统性红斑狼疮中的作用
Keishi Fujio,Toshiyuki Ushijima,Tomohisa Okamura et al.
Keishi Fujio et al.
In systemic lupus erythematosus (SLE), the production of autoantibodies is a crucial characteristic, and B cells play a significant role in its pathogenesis. B cells are the immune cells most associated with the genetic predispositions of S...
Ro5-4864, a translocator protein ligand, regulates T cell-mediated inflammatory responses in skin [0.03%]
RO5-4864，一种转运蛋白配体，调节皮肤T细胞介导的炎症反应
Yuka Sendai,Kazuyoshi Takeda,Keisuke Ohta et al.
Yuka Sendai et al.
Translocator protein (TSPO) is a mitochondrial outer membrane protein expressed on a variety of immune cells, including macrophages, dendritic cells, and T cells, in addition to neurons and steroid-producing cells. Previous studies of TSPO ...
JunB is required for CD8+ T cell responses to acute infections [0.03%]
JunB蛋白对于CD8+t细胞抗急性感染的免疫反应是必须的
Shukla Sarkar,Naoyuki Taira,Tsung-Han Hsieh et al.
Shukla Sarkar et al.
Basic-leucine zipper transcription factor ATF-like (BATF) and interferon regulatory factor 4 (IRF4) are crucial transcription factors for generation of cytotoxic effector and memory CD8+ T cells. JunB is required for expression of genes con...
Eosinophil and B cell dynamics in the milky spots from Schistosoma mansoni-infected mice - Comparison with spleen and bone marrow, and extramedullary eosinopoiesis [0.03%]
感染血吸虫的小鼠乳斑中嗜酸性粒细胞和B细胞的动力学变化与脾脏及骨髓的比较，并观察骨髓外的嗜酸性粒细胞生成
Bruno Marques Vieira,Beatriz Fernandes Almeida,Marcelo Pelajo Machado
Bruno Marques Vieira
The milky spots are structures found in the omentum of humans and other vertebrates, representing a fraction of the lymphomyeloid tissue associated with the celom. They majorly consist of B lymphocytes, T lymphocytes, and macrophages. Also ...
PP2A negatively regulates NK cell T-bet expression and anti-tumor effector function [0.03%]
PP2A通过抑制自然杀伤细胞T-bet表达负调控其抗肿瘤效应功能
Yui Shinzawa,Daisuke Hara,Yuki Shinguryo et al.
Yui Shinzawa et al.
The transcription factor T-bet is essential for the anti-tumor effector function of natural killer (NK) cells, but the mechanism regulating its expression in NK cells remains unclear. In this study, we aimed to identify an NK cell-intrinsic...