Secreted phospholipase A2 regulates intercellular communications by coordinating extracellular phospholipid metabolism [0.03%]
分泌型磷脂酶A2通过协调细胞外磷脂代谢调节细胞间通讯
Makoto Murakami
Makoto Murakami
Lipids play fundamental roles in life. In essence, "phospholipase A2" (PLA2) indicates a group of enzymes that release fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids. To date, more than 50 enzymes...
Tsukasa Nabekura
Tsukasa Nabekura
Immune cells are classified into adaptive and innate immune cells. Adaptive immune cells-i.e. T cells and B cells-respond to pathogens in an antigen-specific manner and then provide immunological memory, contributing to long-term host defen...
Zoledronic acid attenuates ischemic brain injury by promoting ETS2 and MSR1 expression [0.03%]
zoledronic酸通过促进ETS2和MSR1表达来减轻缺血性脑损伤
Kento Otani,Ryuki Koyama,Jun Tsuyama et al.
Kento Otani et al.
Intracerebral inflammation and brain swelling often worsen the functional prognosis of stroke patients. Post-stroke inflammation is resolved by the removal of inflammatogenic damage-associated molecular patterns (DAMPs) through macrophage s...
Keita Kohno,Makoto Tsuda
Keita Kohno
Neuropathic pain arises from injury or disease to the sensory nervous system and is characterized by intense pain that is disproportionate to the stimulus. However, effective treatments remain limited, highlighting an urgent need for novel ...
Proteasome dysfunction in T cells causes immunodeficiency via cell cycle disruption and apoptosis [0.03%]
因细胞周期紊乱和凋亡导致的免疫缺陷源于T细胞蛋白酶体功能障碍
Erkhembayar Shinebaatar,Junko Morimoto,Rinna Koga et al.
Erkhembayar Shinebaatar et al.
Proteasomes are essential molecular complexes that regulate intracellular protein homeostasis by selectively degrading ubiquitinated proteins. Genetic mutations in proteasome subunits lead to proteasome-associated autoinflammatory syndromes...
Immunogenomic precision medicine: a personalized approach based on immunogenomic cancer evolution [0.03%]
免疫基因组精准医学：基于免疫基因组癌症进化的个性化方法
Yusaku Momoi,Shogo Kumagai,Hiroyoshi Nishikawa
Yusaku Momoi
Cancer progression can be understood as a process of diversification and selection (the evolutionary theory of cancer). The immune system also plays a critical role in this process of diversification and selection. The cancer immunoediting ...
TAK1 Governs Monocyte-Derived Macrophage Development in Acute Sterile Peritonitis [0.03%]
TAK1在急性非感染性腹膜炎中调控单核细胞来源巨噬细胞的发育
Katsuki Iwahori,Kengo Maeda,Hideki Sanjo
Katsuki Iwahori
Monocytes recruited to inflamed tissues differentiate into macrophages, contributing to the resolution of inflammation and tissue repair. However, the mechanisms underlying the development, differentiation, and maturation of these monocyte-...
Rie Hasebe,Hiroki Tanaka,Takeshi Yamasaki et al.
Rie Hasebe et al.
Neural signaling regulates various reactions in our body including immune responses. Neuromodulation of this signaling using artificial neural activation and/or suppression is a potential treatment of diseases and disorders. We here review ...
Tertiary lymphoid structures: chronic inflammatory microenvironments in kidney diseases [0.03%]
三级淋巴样结构：肾脏疾病中的慢性炎症微环境
Takahisa Yoshikawa,Motoko Yanagita
Takahisa Yoshikawa
Chronic kidney disease is a global health problem with high morbidity and mortality rates. Acute kidney injury substantially increases the risk of chronic kidney disease progression, particularly in the elderly, partly because of prolonged ...
Immune responses underpinning acute co-infections with unrelated viruses: timing and location matter [0.03%]
不同病毒急性共同感染背后的免疫反应：时间与位置的影响
Isabelle Jia Hui Foo,Lukasz Kedzierski,Katherine Kedzierska
Isabelle Jia Hui Foo
Immunity to viral infections is generally studied in isolation by measuring immune responses towards a single virus. However, concurrent or sequential viral co-infections can occur in a single host. Viral co-infections can impact antiviral ...