Transduction of Batf family members provides distinct functions to mouse CD8+ T cells [0.03%]
BATF家族成员的转导赋予小鼠CD8⁺T细胞不同的功能
Kenta Kondo,Mina Kumode,Hiroki Satooka et al.
Kenta Kondo et al.
Members of the Batf family, including Batf, Batf2, and Batf3, play critical roles in various immune cell types. Several studies have suggested redundant functions, as they can compensate for each other's functions. Here, we show that transd...
Epitope specificity shapes the CD4+ T cell response to influenza virus infection in mice [0.03%]
流感病毒表位特异性塑造小鼠CD4+t细胞免疫反应
Daiki Mori,Nicolas Sax,Nozomi Shimada et al.
Daiki Mori et al.
Helper CD4+ T cells play a central role in orchestrating protective immune responses during infection and vaccination. Activation of naïve CD4+ T cells is initiated by the recognition of antigenic peptides presented on MHC class II molecul...
David Priest,James Wing
David Priest
In human blood B cells exist in a variety of forms ranging from antigen inexperienced naive cells to long term memory cells, and antibody producing plasma cells. Historically the divisions between these types of cells have been defined by a...
Identification and characterization of CXCL13 producers in bone tissue in response to fasting [0.03%]
饥饿对骨组织CXCL13生成细胞的鉴定与表征
Takuma Okawa,Motoyoshi Nagai,Shinya Fujita et al.
Takuma Okawa et al.
The bone tissue serves as a dynamic reservoir that accommodates diverse immune cell populations during low-energy states such as fasting. Energy-restriction and reduced metabolism induce a transient migration of naïve B cells from Peyer's ...
Repeated mRNA vaccination and breakthrough infection reveal durable dominance but diminishing recall of vaccine-induced CD8⁺ T-cell clones [0.03%]
重复的mRNA疫苗接种和突破性感染揭示了疫苗诱导的CD8⁺T细胞克隆持久的主导地位但回忆作用减弱
Peng Xu,Satoshi Ueha,Hiroyasu Aoki et al.
Peng Xu et al.
Successive mRNA vaccinations preserve SARS-CoV-2-specific T-cell immunity, but how individual CD8⁺ T-cell clones behave across repeated booster doses and breakthrough infection (BTI) remains poorly defined. We longitudinally tracked bulk C...
T cell help is a limiting factor for rare anti-influenza memory B cells to reenter germinal centers and generate potent broadly neutralizing antibodies [0.03%]
T细胞的辅助是稀有抗流感记忆B细胞重新进入生发中心并生成高效广谱中和抗体的限制性因素
Yang Xue,Yuki Tai,Hiromi Yamamoto et al.
Yang Xue et al.
Development of vaccines eliciting broadly neutralizing influenza antibodies (bnAbs) is an extraordinary challenge. One hypothetical proposal is that CD4+ T cell help to rare immuno-subdominant bnAb class memory B cells is one critical facto...
Salmonella Typhimurium evades from host immunity and antibiotics in monocytes [0.03%]
沙门氏菌逃避免噬细胞免疫和抗生素的机制研究
Uki Kimura,Nobuhiro Matsuyama,Karen Saiki et al.
Uki Kimura et al.
Intracellular bacteria can survive in vivo, evading host immunity and antibiotics. Salmonella persists in organs such as spleen by invading in the phagocytic cells. However, it remains controversial which specific cell populations, e.g., ma...
Microbiota regulation of gut-brain neuroimmune crosstalk in early life [0.03%]
肠道微生物调节生命早期的肠-脑神经免疫交叉对话
Purnima Ravisankar,Daniel Sen Hoi Wong,Melody Y Zeng
Purnima Ravisankar
In early life, the immune and nervous systems are highly plastic and engage in complex, bidirectional communication that is critical for establishing postnatal immune tolerance, gut and brain development, and responses to environmental chal...
Zika virus exacerbates EAE by inducing the production of T cell-attracting chemokines in astrocytes [0.03%]
寨卡病毒通过诱导星形胶质细胞产生T细胞趋化因子而加重自身免疫性脑脊髓炎
Naganori Kamiyama,Benjawan Saechue,Nozomi Sachi et al.
Naganori Kamiyama et al.
Recent outbreaks of the ZIKA virus (ZIKV) in Brazil and Puerto Rico have been linked to an increase in the incidence of fetal microcephaly and Guillain-Barre syndrome. In addition, although a causal relationship remains unproven, ZIKV has b...
TLR7 responses to nucleosides drive sialadenitis in Slc29a3-deficient mice [0.03%]
Slc29a3缺陷小鼠中对核苷的TLR7应答驱动唾液腺炎发生
Takuma Shibata,Kotono Okabe-Kibe,Hu Chen et al.
Takuma Shibata et al.
Autoimmune sialadenitis is a hallmark of IgG4-related disease (IgG4-RD) and Sjögren syndrome (SS). The single-stranded RNA sensor TLR7 has been shown as a driver of sialadenitis. Although TLR7 is activated by ssRNA degradation products suc...