Molecular mechanisms for direct sensing of virus-like antigens by B cells [0.03%]
B细胞直接感应类似病毒的抗原的分子机制
Wei Cheng,Julie Zikherman
Wei Cheng
Particulate antigens (Ags) such as viruses can often induce strong B cell responses in vivo very effectively, but the molecular determinants of this complex process remain incompletely understood. In this review, we focus on recent mechanis...
The Role of IL-4+ Memory T Cells in SARS-CoV-2 Booster Vaccination [0.03%]
IL-4+记忆T细胞在新冠病毒疫苗加强针接种中的作用
Jumana Khalil,Kosuke Miyauchi,Yosie Suzuki et al.
Jumana Khalil et al.
Vaccines effectively stimulate protective immune responses in healthy individuals, but the precise roles of germinal center (GC) and follicular helper T (TFH) cells in SARS-CoV-2 vaccine responses are not fully understood. This study used a...
The thyroid hormone receptor beta (TR-β) signaling controls pathogenic Th17 cells in autoimmune disease [0.03%]
甲状腺激素受体β（TR-β）信号通路调控自身免疫性疾病中的致病性Th17细胞
Yoshimitsu Doi,Ben J E Raveney,Atsuko Kimura et al.
Yoshimitsu Doi et al.
The role of the thyroid hormone receptor beta (TR-β) in the immune system remains poorly understood; although its effect on TGF-βsignaling has been reported in non-immune systems. Here, we report that Thrb is highly expressed in pathogeni...
TCR representation learning with protein language models: a comprehensive review [0.03%]
基于蛋白质语言模型的 TCR 表征学习综述
Kyohei Kinoshita,Tetsuya J Kobayashi
Kyohei Kinoshita
The T cell receptor (TCR) repertoire is a valuable source of information that reflects an individual's immune status and infection history. However, due to the exceptional diversity and complexity of the TCR repertoire, predicting its funct...
Folic acid supplementation during pregnancy alleviates food allergy in offspring by inhibiting mast cell degranulation [0.03%]
叶酸补充通过抑制肥大细胞脱颗粒缓解子代食物过敏
Qianwei Wang,Yuchi Jiang,Sufang Duan et al.
Qianwei Wang et al.
Studies have been exploring the connection between vitamins intake and development of food allergy, with a particular focus on folic acid (FA). However, the impact of FA supplementation on food allergy remains a subject of debate. In the pr...
Interleukin-35 regulates the differentiation of regulatory T cells through the JAK-STAT pathway and influences glutamine metabolism in ARDS [0.03%]
白细胞介素35通过JAK-STAT信号通路调节ARDS中调节性T细胞的分化并影响其谷氨酰胺代谢
Qiao-Zhi Peng,Mu Zhang,Ai-Ping Zhang et al.
Qiao-Zhi Peng et al.
The aim of this study was to elucidate the effect of IL-35 on T cell differentiation and its mechanism. We evaluated the therapeutic effect of IL-35 on acute respiratory distress syndrome (ARDS) using clinical samples and mouse cecum ligati...
Epigenomic Control of Immunity: From Mechanisms to Therapeutic Targets in Inflammatory Bowel Diseases [0.03%]
表观基因组在免疫中的调控：从机制到治疗靶点(IBD为例)
Han-Yu Shih,Giuseppe Sciumè,Yohei Mikami
Han-Yu Shih
This review presents an overview of the emerging roles of epigenomic regulation in immune cell function, with a particular focus on its relevance in inflammatory bowel disease (IBD). Epigenetic mechanisms, including DNA methylation, histone...
Zehua Shang,Lei Wang,Wen Zhou
Zehua Shang
Three-prime repair exonuclease 1 (TREX1) is the major 3' to 5' DNA exonuclease in mammals and plays an essential role in preserving immune homeostasis by controlling cytosolic DNA sensing. By degrading excess self and foreign DNA, TREX1 lim...
Fecal Microbiota Transplantation for Immune Regulation: Improving Ulcerative Colitis and Enhancing Cancer Immunotherapy [0.03%]
粪便微生物群移植在免疫调节中的应用：改善溃疡性结肠炎和增强癌症免疫治疗
Xiaochen Zhang,Dai Ishikawa,Akihito Nagahara
Xiaochen Zhang
The gut microbiota plays an integral role in maintaining health and regulating various host functions, including immune responses. Fecal microbiota transplantation (FMT) has emerged as a promising therapeutic approach to restore gut microbi...