Selective decreases in regulatory B cell (Breg) subsets in active uveitis: IL-10+CD19+CD24hiCD38hiBreg in patients and B10 Breg in mice [0.03%]
活动性葡萄膜炎中调节性B细胞(Breg)亚群的减少：患者和小鼠中的IL-10+CD19+CD24hiCD38hiBreg和B10 Breg
Yi-Hsing Chen,Xiaozhe Zhang,Malihe Eskandarpour et al.
Yi-Hsing Chen et al.
Several regulatory B lymphocyte (Breg) subsets have been implicated in autoimmune diseases. We investigated Breg subsets in non-infectious uveitis (NIU) and in mouse models of experimental autoimmune uveitis (EAU). Bloods from NIU patients ...
Distinct fibrosis-associated macrophage subsets coordinate iron metabolism in pulmonary fibrosis [0.03%]
不同的纤维化相关巨噬细胞亚群在肺纤维化中铁代谢的协调作用
Hiroshi Nabeshima,Kiyoharu Fukushima,Yu-Chen Liu et al.
Hiroshi Nabeshima et al.
Pulmonary fibrosis has a poor prognosis due to challenges in early diagnosis and therapeutic intervention. Current treatments remain largely ineffective due to an incomplete understanding of the complex pathology, including the interactions...
PDLIM4 promotes dephosphorylation of STAT transcription factors by recruiting PTP-BL and inhibits Th1, Th2, and Th17 cell differentiation [0.03%]
PDLIM4通过募集PTP-BL促进STAT转录因子去磷酸化并抑制Th1，Th2和Th17细胞分化
Aya Jodo,Masakiyo Nakahira,Yuta Kochi et al.
Aya Jodo et al.
STAT transcription factors are activated by tyrosine phosphorylation after cytokine stimulation and are critical for the differentiation of T-helper (Th) cells into particular Th lineage subsets. How STAT-mediated Th cell differentiation is...
Hiroyuki Yagyu,Masahiro Kiuchi,Kiyoshi Hirahara
Hiroyuki Yagyu
Immune memory is central to host protection against pathogens and contributes to the pathogenesis of chronic inflammatory diseases. Beyond canonical cytokines and antigenic stimuli, metabolic signals have emerged as pivotal regulators of T-...
Mizuki Taguchi,Sébastien de La Forest Divonne,Ryo Morimoto
Mizuki Taguchi
Adaptive immunity is often viewed as a defining innovation of vertebrates, characterized by somatically diversified antigen-receptors and clonal lymphocyte lineages. Yet the evolutionary origins of such systems remain incompletely understoo...
RNF213-TRAF2 interaction enhances inflammatory responses via NF-κB activation in moyamoya disease [0.03%]
RNF213-TRAF2相互作用通过NF-κB激活增强 Moyamoya病的炎症反应
Mitsutaka Yasuda,Kaoru Murakami,Jing-Jing Jiang et al.
Mitsutaka Yasuda et al.
Moyamoya disease (MMD) is a cerebrovascular disorder that predominantly affects East Asian populations. It is characterized by progressive stenosis or occlusion of terminal internal carotid arteries. Although inflammatory and autoimmune res...
ELAVL1 modulates periodontal ligament fibroblast pyroptosis in periodontitis through the JAK2/STAT3/NLRP3 axis [0.03%]
ELAVL1通过JAK2/STAT3/NLRP3轴调节牙周病中的牙周韧带成纤维细胞焦亡
Huayong Zhan,Ge Shi,Qin Xie et al.
Huayong Zhan et al.
Periodontitis is an inflammatory disorder that leads to the destruction of periodontal tissues. Pyroptosis, related to the NLRP3 inflammasome, is implicated in the pathogenesis of periodontitis. ELAVL1, an m6A reader, is associated with inf...
Overexpression of the transcriptional corepressor Tle1 enhances effector proliferation of CD8+ T cells during acute and chronic viral infections [0.03%]
转录共抑制因子Tle1的过表达可增强CD8⁺T细胞在急性期和慢性期病毒感染过程中的效应增殖能力
Ryotaro Shiga,Sotaro Fujisawa,Yamato Tanabe et al.
Ryotaro Shiga et al.
The transcriptional corepressor Tle (transducin-like enhancer of split) proteins interact with transcription factors such as TCF-1 and Runx3 to regulate transcriptional programmes during cellular development and differentiation; however, th...
Yudai Hirano,Yoshihiko Tomofuji,Ryuya Edahiro et al.
Yudai Hirano et al.
The gut microbiome has emerged as an important environmental factor in the pathogenesis of autoimmune diseases. Advances in high-throughput sequencing technologies have enabled comprehensive characterization of the gut microbiome, providing...
Single-cell RNA-sequencing of myasthenia gravis reveals transcriptional heterogeneity and dysfunction of immune cell populations [0.03%]
单细胞RNA测序揭示重症肌无力中免疫细胞群的转录异质性和功能障碍
Qingjun Wu,Yingyu Guo,Liying Zhou et al.
Qingjun Wu et al.
The purpose of this study was to explore the composition and function of immune cell subsets at the single cell level in thymus and peripheral blood of patients with myasthenia gravis (MG). A total of 9701 and 23846 cells respectively origi...