Role of group 2 innate lymphoid cells in intranasal sensitization-induced allergic rhinitis in mice [0.03%]
第2组固有淋巴样细胞在鼻黏膜变应原致敏小鼠过敏性鼻炎中的作用研究
Yukinori Kato,Tetsuji Takabayashi,Anna Shimizu et al.
Yukinori Kato et al.
Cells of the innate immune system, specifically group 2 innate lymphoid cells (ILC2s), play an important role in type 2 inflammation. However, their involvement in allergic rhinitis remains unclear. Thus, in this study, we aimed to clarify ...
Functional Diversity and Tissue-Specific Regulation of Group 2 Innate Lymphoid Cells in Barrier Immunity [0.03%]
屏障免疫中2型固有淋巴细胞的功能多样性及组织特异性调控
Mitsuki Ito,Yunzi Yan,Naoko Satoh-Takayama
Mitsuki Ito
Group 2 innate lymphoid cells (ILC2s) contribute to the maintenance of tissue homeostasis by promoting tissue repair and regulating immune responses. However, excessive or prolonged activation of ILC2s can induce chronic inflammation and ti...
Interaction between neurons and microglia in healthy and disease states [0.03%]
健康状态和疾病状态下神经元与小胶质细胞的相互作用
Ayaka Nakamura,Takashi Shichita
Ayaka Nakamura
Interactions between neurons and microglia are essential for various brain functions under both healthy and pathological states. Microglia have classical functions as immune cells, causing cerebral inflammation, whereas their reparative rol...
Neuroprotective crosstalk from vitamin B12 and sphingolipid signaling pathways in therapy for multiple sclerosis [0.03%]
维生素B12和鞘脂信号通路在治疗多发性硬化症中的神经保护作用
Yasuyuki Kihara,Jerold Chun
Yasuyuki Kihara
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS) characterized by neuroinflammation, demyelination, and neurodegeneration. Among disease-modifying therapies (DMTs), sphingosine 1-phosph...
Direct analysis of hepatic stellate cells with flow cytometry in specimens derived from the human liver [0.03%]
人肝组织标本的直接流式分析检测肝星状细胞
Toshiaki Bando,Hirotaka Sato,Shunsuke Uno et al.
Toshiaki Bando et al.
Background & aims: Hepatic stellate cells (HSCs) play a crucial role in liver fibrosis. However, the methodology to directly assess the biology of primary HSCs in human liver specimens is yet to be established. In this st...
The Chitosan Nanoparticle-based Adjuvant CH-100 Orchestrates Multifaceted Innate Immune Activation via STING-Dependent and -Independent Pathways [0.03%]
基于壳聚糖纳米颗粒的免疫佐剂CH-100通过STING依赖性和非依赖性途径协调多方面的先天免疫激活
Eri Nagai,Daisuke Ori,Norisuke Kano et al.
Eri Nagai et al.
Adjuvants enhance vaccine efficacy by activating innate immunity, yet the mechanisms of nanoparticle-based adjuvants remain incompletely defined. Here, we characterize CH-100, a chitosan nanoparticle adjuvant, and its capacity to coordinate...
Oligoclonal expansion of IgG+ B cells along with Tfh cell response is associated with a better outcome in endometrial cancer [0.03%]
IgG+B细胞寡克隆扩增与Tfh细胞反应相关并预示子宫内膜癌患者有更好的预后
Mayu Fujioka,Shusei Fujioka,Hiroyuki Yoshitomi et al.
Mayu Fujioka et al.
B cells play a critical role in tumor immunity, with their presence associated with improved prognosis in various cancers, including endometrial cancer (EC). However, the nature of the B cell response within the tumor microenvironment (TME)...
Anti-human TLR7 antibody for therapeutic intervention in systemic lupus erythematosus [0.03%]
抗人TLR7抗体在系统性红斑狼疮治疗干预中的应用研究
Ryutaro Fukui,Yusuke Murakami,Atsuo Kanno et al.
Ryutaro Fukui et al.
Toll-like receptor 7 (TLR7) is an endosomal sensor that responds to both pathogen-derived and self-derived single-stranded RNA (ssRNA). Responses of TLR7 to self-derived ssRNA have been implicated in the development of autoimmune diseases, ...
Role of Themis in peripheral CD8 T cells in hapten-induced allergic skin inflammation [0.03%]
Thymis在半抗原诱导的过敏性皮肤炎症中外周CD8 T细胞中的作用
Masayuki Kitajima,Toshiyuki Okada,Kenta Nakano et al.
Masayuki Kitajima et al.
Themis is a T-cell-specific protein that is critically required for positive selection in the thymus. However, its function in T-cell receptor (TCR) responses during allergic skin inflammation remains unclear. To investigate the function of...
Vaccine adjuvants as stand-alone immunoprophylaxis in strategies for 100-day rapid responses to future pandemics [0.03%]
疫苗佐剂作为独立免疫预防策略应对未来大流行病的百日快速反应方案
Niloufar Kavian,Kouji Kobiyama,Ken J Ishii et al.
Niloufar Kavian et al.
The COVID-19 pandemic accelerated vaccinology progress, driving rapid vaccine development for infectious and non-infectious diseases. However, challenges persist: malaria, HIV, and dengue lack fully effective vaccines, whereas influenza and...