Acute malaria suppresses the B lymphocytic niche in the bone marrow through the alteration of CXCL12-abundant reticular cells [0.03%]
急性疟疾通过改变富含CXCL12的网状细胞来抑制骨髓中的B淋巴细胞niche
Michelle Sue Jann Lee,Julia Matsuo-Dapaah,Camila Del Rosario Zorrilla et al.
Michelle Sue Jann Lee et al.
Bone marrow is a dynamic organ composed of stem cells that constantly receive signals from stromal cells and other hematopoietic cells in the niches of the bone marrow to maintain hematopoiesis and generate immune cells. Perturbation of the...
Prevention of experimental autoimmune encephalomyelitis by targeting 6-sulfo sialyl Lewis X glycans involved in lymphocyte homing [0.03%]
通过靶向参与淋巴细胞归巢的6-磺基唾液酸Lewis X糖链预防实验性自身免疫性脑脊髓炎
Qianqian Liu,Wei Xiong,Sachiyo Obara et al.
Qianqian Liu et al.
Lymphocyte homing to peripheral lymph nodes (PLN) is critical for immune surveillance. However, autoimmune diseases such as multiple sclerosis (MS) can occur due to excessive immune responses in the PLN. Here we show that 6-sulfo sialyl Lew...
Crystal structure of the complex of CLEC12A and an antibody that interferes with binding of diverse ligands [0.03%]
CLEC12A及其抗体的复合物晶体结构：该抗体干扰了多种配体的结合
Shotaro Mori,Masamichi Nagae,Sho Yamasaki
Shotaro Mori
C-type lectin receptors (CLRs) are a family of pattern recognition receptors, which detect a broad spectrum of ligands via small carbohydrate-recognition domains (CRDs). CLEC12A is an inhibitory CLR that recognizes crystalline structures su...
Meghan Kates,Samuel D Saibil
Meghan Kates
Adoptive cell therapy (ACT) is an immunotherapeutic approach that involves isolating T cells from a patient, culturing them ex vivo, then reinfusing the cells back into the patient. Although this strategy has shown remarkable efficacy in he...
Essential role of CD155 glycosylation in functional binding to DNAM-1 on natural killer cells [0.03%]
CD155糖基化在自然杀伤细胞上的DNAM-1功能结合中的重要作用
Saeko Tahara,Genki Okumura,Tomohei Matsuo et al.
Saeko Tahara et al.
The cluster of differentiation 155 (CD155) is highly expressed on tumor cells and augments or inhibits the cytotoxic activities of natural killer (NK) cells and T cells through its receptor ligands DNAX accessory molecule 1 (DNAM-1) and T-c...
A purified diet affects intestinal epithelial proliferation and barrier functions through gut microbial alterations [0.03%]
净化饮食通过改变肠道微生物影响肠上皮细胞增殖和屏障功能
Hiroaki Shiratori,Kisara M Hattori,Kazuaki Nakata et al.
Hiroaki Shiratori et al.
The gut microbiota plays a crucial role in maintaining epithelial barrier function. Although multiple studies have demonstrated the significance of dietary factors on the gut microbiota and mucosal barrier function, the impact of a purified...
Yagiz Pat,Duygu Yazici,Paolo D&#x;Avino et al.
Yagiz Pat et al.
The epithelial barrier theory links the recent rise in chronic non-communicable diseases, notably autoimmune and allergic disorders, to environmental agents disrupting the epithelial barrier. Global pollution and environmental toxic agent e...
Trends in cell medicine: from autologous cells to allogeneic universal-use cells for adoptive T-cell therapies [0.03%]
细胞医学的趋势：从自体细胞到同种异体通用供体细胞的适应性T细胞治疗
Hiroshi Kawamoto,Kyoko Masuda
Hiroshi Kawamoto
In currently ongoing adoptive T-cell therapies, T cells collected from patients are given back to them after ex vivo activation and expansion. In some cases, T cells are transduced with chimeric antigen receptor (CAR) or T-cell receptor (TC...
Hiroyasu Tsutsuki,Tianli Zhang,Takaaki Akaike et al.
Hiroyasu Tsutsuki et al.
Innate immunity plays an important role in host defense against microbial infections. It also participates in activation of acquired immunity through cytokine production and antigen presentation. Pattern recognition receptors such as Toll-l...
The role of IFN-γ-mediated host immune responses in monitoring and the elimination of Toxoplasma gondii infection [0.03%]
IFN-γ介导的宿主免疫反应在监控和清除弓形虫感染中的作用
Fumiaki Ihara,Masahiro Yamamoto
Fumiaki Ihara
Toxoplasma gondii is a pathogenic protozoan parasite of the Apicomplexa family that affects approximately 30% of the world's population. Symptoms are usually mild in immunocompetent hosts, but it can pose significant health risks to immunos...