Disruption of post-thymic tolerance in skin-reactive TCR transgenic mice through the interaction of lymphopenia and intestinal microbiota [0.03%]
淋巴细胞减少与肠道微生物群的相互作用通过皮肤反应性TCR转基因小鼠中后胸腺耐受中断干扰
Hodaka Hayabuchi,Yukiko Tokifuji,Hayato Takahashi et al.
Hodaka Hayabuchi et al.
Autoimmune diseases often arise from conditions where the immune system is compromised. While lymphopenia-induced proliferation (LIP) is crucial for immune system development and maturation, it is also caused by environmental insults, such ...
Taiichiro Shirai,Akiko Nakai,Kazuhiro Suzuki
Taiichiro Shirai
Efficient induction of humoral immune responses depends on orchestrated migration of B cells within lymphoid organs, which is governed by G protein-coupled receptors (GPCRs) responding to chemoattractants, represented by chemokines. After l...
TAK1-binding proteins (TAB)2 and TAB3 are redundantly required for TLR-induced cytokine production in macrophages [0.03%]
TAK1结合蛋白(TAB)2和TAB3是巨噬细胞中TLR诱导的细胞因子产生的冗余必需物
Tanveer Ali,Huong Minh Nguyen,Naeem Abbas et al.
Tanveer Ali et al.
Transforming growth factor-β-activated kinase 1 (TAK1) plays a pivotal role in innate and adaptive immunity. TAK1 is essential for the activation of mitogen-activated protein kinases (MAPKs) and nuclear factor (NF)-κB pathways downstream ...
Identification of potential C1-binding sites in the immunoglobulin CL domains [0.03%]
鉴定免疫球蛋白轻链恒定区中的潜在C1结合位点
Saeko Yanaka,Atsuji Kodama,Shigetaka Nishiguchi et al.
Saeko Yanaka et al.
Immunoglobulin G (IgG) molecules that bind antigens on the membrane of target cells spontaneously form hexameric rings, thus recruiting C1 to initiate the complement pathway. However, our previous report indicated that a mouse IgG mutant la...
Recent advances regarding the potential roles of invariant natural killer T cells in cardiovascular diseases with immunological and inflammatory backgrounds [0.03%]
近期关于不变自然杀伤T细胞在心血管疾病中潜在作用的进展（具有免疫和炎症背景）
Kazuya Iwabuchi,Masashi Satoh,Kazuhisa Yoshino et al.
Kazuya Iwabuchi et al.
Invariant natural killer T (iNKT) cells, which bear αβ-type T-cell antigen-receptors (TCRs), recognize glycolipid antigens in a cluster of differentiation 1d (CD1d)-restricted manner. Regarding these cells, the unique modes of thymic sele...
Immunogenicity and protective capacity of a CpG ODN adjuvanted alum adsorbed bivalent meningococcal outer membrane vesicle vaccine [0.03%]
新型脑膜炎双价组分疫苗的免疫原性和保护效果研究
Tugce Canavar Yildirim,Yasemin Ozsurekci,Muzaffer Yildirim et al.
Tugce Canavar Yildirim et al.
Invasive meningococcal disease (IMD) is caused by Neisseria meningitidis, with the main serogroups responsible for the disease being A, B, C, W, X, and Y. To date, several vaccines targeting N. meningitidis have been developed albeit with a...
High CD62L expression predicts the generation of chimeric antigen receptor T cells with potent effector functions [0.03%]
CD62L高表达预示着生成具有较强效应功能的CAR-T细胞
Hitomi Kasuya,Haosong Zhang,Yusuke Ito et al.
Hitomi Kasuya et al.
The efficient generation of chimeric antigen receptor (CAR) T cells is highly influenced by the quality of apheresed T cells. Healthy donor-derived T cells usually proliferate better than patients-derived T cells and are precious resources ...
Causal modulation of lipid metabolism may shape the inflammatory microenvironment and potentially augment immunotherapy: a comprehensive genetic landscape revealed by Mendelian randomization analysis [0.03%]
脂质代谢的因果调节可能塑造炎症微环境并潜在增强免疫治疗：孟德尔随机化分析揭示的全面遗传景观
Wenjie Li,Wei Wang
Wenjie Li
Previous observational and experimental studies have suggested a relationship between statin treatments and the augmentation of immunotherapy effects; however, the causal role of statin usage in promoting antitumor immunity remains largely ...
An inhibitory immunoreceptor Allergin-1 regulates the intestinal dysbiosis and barrier function in mice [0.03%]
抑制性免疫受体Allergin-1调节小鼠的肠道菌群失衡和屏障功能
Yu-Hsien Lin,Satoko Tahara-Hanaoka,Nozomu Obana et al.
Yu-Hsien Lin et al.
The intestinal barrier consists of mucosal, epithelial, and immunological barriers and serves as a dynamic interface between the host and its environment. Disruption of the intestinal barrier integrity is a leading cause of various gastroin...
Metabolic reprogramming and macrophage polarization in granuloma formation [0.03%]
肉芽肿形成中巨噬细胞极化和代谢重塑
Satoshi Nakamizo,Kenji Kabashima
Satoshi Nakamizo
This review article delves into the complexities of granuloma formation, focusing on the metabolic reprogramming within these immune structures, especially in tuberculosis and sarcoidosis. It underscores the role of the monocyte-macrophage ...