Susan R Quinn,Luke A O&#x;Neill
Susan R Quinn
Toll-like receptors (TLRs) in the host recognize conserved microbial products and defend against pathogenic attack by initiating an immune response via signalling pathways that lead to an increase in immune and inflammatory gene expression....
HIV-1 Nef impairs multiple T-cell functions in antigen-specific immune response in mice [0.03%]
HIV-1Nef削弱小鼠抗原特异性免疫反应中的多种T细胞功能
Hideki Fujii,Manabu Ato,Yoshimasa Takahashi et al.
Hideki Fujii et al.
The viral protein Nef is a key element for the progression of HIV disease. Previous in vitro studies suggested that Nef expression in T-cell lines enhanced TCR signaling pathways upon stimulation with TCR cross-linking, leading to the propo...
An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation [0.03%]
关于转录因子GATA3介导的Th1和Th2细胞分化调节的最新研究观点
Ryoji Yagi,Jinfang Zhu,William E Paul
Ryoji Yagi
CD4 T(h) are critical for orchestrating adaptive immune responses. The expression of the transcription factor GATA3 (GATA-binding protein 3) is up-regulated or down-regulated during T(h)2 or T(h)1 cell differentiation, respectively. Further...
Specific expression of PAD4 and citrullinated proteins in lung cancer is not associated with anti-CCP antibody production [0.03%]
PAD4及瓜氨酸蛋白在肺癌中的特殊表达与抗环瓜氨酸肽抗体的产生无关
Zsuzsanna Baka,Péter Barta,György Losonczy et al.
Zsuzsanna Baka et al.
Anti-citrullinated protein antibodies (ACPAs), produced against citrullinated proteins, are diagnostic and prognostic markers of rheumatoid arthritis (RA). The underlying mechanism that explains the connection of smoking, citrullination [ca...
Recombination activation gene-2-deficient blastocyst complementation analysis reveals an essential role for nuclear factor I-A transcription factor in T-cell activation [0.03%]
重组激活基因-2缺陷型囊胚互补分析揭示核因子I-A转录因子在T细胞活化中的重要作用
Natarajan Muthusamy,Hui-Chen Chen,Girish Rajgolikar et al.
Natarajan Muthusamy et al.
Nuclear factor I (NFI)-A is a member of the NFI family of transcription factors implicated in regulation of granulocyte differentiation. However, its role in the lymphoid lineage is not known. NFI-A deficiency results in perinatal lethality...
Generation and characterization of peptide mimotopes specific for anti ErbB-2 monoclonal antibodies [0.03%]
抗ErbB-2单克隆抗体的多肽模拟表位的筛选及鉴定
Esther J Witsch,Georg Mahlknecht,Jean Wakim et al.
Esther J Witsch et al.
The erbb-2 gene receptor is often over-expressed in human cancer and its overexpression is accompanied by worse prognosis. Targeting erbb-2 gene with antibodies is an effective approach to curtail the progression of erbb-2 gene-expressing c...
The B lineage transcription factor E2A regulates apoptosis in chronic lymphocytic leukemia (CLL) cells [0.03%]
B淋巴系转录因子E2A调节慢性淋巴细胞白血病(CLL)细胞凋亡
Lela Kardava,Qi Yang,Anthony St Leger et al.
Lela Kardava et al.
Chronic lymphocytic leukemia (CLL) is a common malignancy characterized by the accumulation of B lymphocytes with an antigen-experienced activated CD19(+)CD5(+) clonal phenotype. Clinically, ∼50% of cases will behave more aggressively. Her...
Antigen-independent development of Foxp3+ regulatory T cells suppressing autoantibody production in experimental pemphigus vulgaris [0.03%]
在实验性寻常型天疱疮中FoxP3⁺自然调节性T细胞的抗原非依赖性发育及其对自身抗体产生的抑制作用
Tomoaki Yokoyama,Satoshi Matsuda,Yujiro Takae et al.
Tomoaki Yokoyama et al.
The CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) play suppressive roles in various types of autoimmunity. It has been reported that Tregs develop in the thymus after high-affinity interaction of their TCR with self-peptide/MHC ligands m...
Affinity maturation of B cells involves not only a few but a whole spectrum of relevant mutations [0.03%]
亲和力成熟的B细胞涉及的不是少数而是相关的整个突变谱系
Armin A Weiser,Nicole Wittenbrink,Lei Zhang et al.
Armin A Weiser et al.
Affinity maturation of B lymphocytes within germinal centers involves both diversification of their B-cell receptors (BCRs) by somatic hypermutation (SHM) and a crucial receptor-mediated selection step. However, in contrast to recent advanc...
Lack of B and T lymphocyte attenuator exacerbates autoimmune disorders and induces Fas-independent liver injury in MRL-lpr/lpr mice [0.03%]
B 和 T 淋巴细胞活化调节因子的缺乏加重自身免疫性疾病并诱导 MRL-lpr/lpr 小鼠发生 Fas 非依赖性肝损伤
Yoshihiro Oya,Norihiko Watanabe,Yoshihisa Kobayashi et al.
Yoshihiro Oya et al.
MRL/Mp-Fas (lpr) (MRL-lpr) mice develop a systemic autoimmune disease and are considered to be a good model for systemic lupus erythematosus in humans. We have recently shown that mice lacking B and T lymphocyte attenuator (BTLA), an inhibi...