Modeling the extension of ovarian function after therapeutic targeting of the primordial follicle reserve [0.03%]
卵巢原始卵泡库经治疗靶向后的卵巢功能持续期的建模分析
Joshua Johnson,John W Emerson,Annika Smith et al.
Joshua Johnson et al.
Background: Women are increasingly choosing to delay childbirth, and those with low ovarian reserves indicative of primary ovarian insufficiency are at risk for sub- and infertility and also the early onset of menopause. ...
Moving toward totipotency: the molecular and cellular features of totipotent and naive pluripotent stem cells [0.03%]
走向全能性：全能干细胞和原始态多能干细胞的分子与细胞特性
Lingyue Hua,Yuyang Peng,Liying Yan et al.
Lingyue Hua et al.
Background: Dissecting the key molecular mechanism of embryonic development provides novel insights into embryogenesis and potential intervention strategies for clinical practices. However, the ability to study the molecu...
Human Reproduction Update Editorial Team
Human Reproduction Update Editorial Team
RNA modifications in female reproductive physiology and disease: emerging roles and clinical implications [0.03%]
女性生殖生理和疾病中的RNA修饰：新兴作用和临床意义
Yu Xiang,Hsun-Ming Chang,Peter C K Leung et al.
Yu Xiang et al.
Background: RNA modifications, collectively known as the epitranscriptome, represent the third layer of gene regulation, influencing gene expression at transcriptional, post-transcriptional, and translational levels. RNA-...
Ethical considerations for advancing research using organoid models derived from the placenta [0.03%]
利用胎盘衍生的类器官模型进行研究的伦理考量
Olivier J M Schäffers,Joost Gribnau,Bas B van Rijn et al.
Olivier J M Schäffers et al.
Background: The advent of organoid culture systems has revolutionized our ability to model and study complex tissues in vitro. The placenta is one of the last human organs to have a functional organoid model developed: tr...
Noemi Castelluccio,Katharina Spath,Danyang Li et al.
Noemi Castelluccio et al.
Mitochondrial DNA (mtDNA) diseases pose unique challenges for genetic counselling and require tailored approaches to address recurrence risks and reproductive options. The intricate dynamics of mtDNA segregation and heteroplasmy shift signi...
Molecular insights into sperm head shaping and its role in human male fertility [0.03%]
精子头部形态的人类雄性生育中的作用及分子机制解析
Jiaxin He,Xinle Lin,Chen Tan et al.
Jiaxin He et al.
Background: Sperm head shaping, controlled by the acrosome-acroplaxome-manchette complex, represents a significant morphological change during spermiogenesis and involves numerous proteins expressed in a spatially and tem...
Harnessing omics data for drug discovery and development in ovarian aging [0.03%]
利用组学数据进行卵巢衰老的药物发现与开发
Fengyu Zhang,Ming Zhu,Yi Chen et al.
Fengyu Zhang et al.
Background: Ovarian aging occurs earlier than the aging of many other organs and has a lasting impact on women's overall health and well-being. However, effective interventions to slow ovarian aging remain limited, primar...
Defects in mRNA splicing and implications for infertility: a comprehensive review and in silico analysis [0.03%]
mRNA剪接缺陷与不孕不育的关系：全面综述和计算机模拟分析
Kuokuo Li,Yuge Chen,Yuying Sheng et al.
Kuokuo Li et al.
Background: mRNA splicing is a fundamental process in the reproductive system, playing a pivotal role in reproductive development and endocrine function, and ensuring the proper execution of meiosis, mitosis, and gamete f...
Parental conditions, modifiable lifestyle factors, and first trimester growth and development: a systematic review [0.03%]
父母状况，可改变的生活方式因素与早期孕期发育：系统性回顾
Naomi Graafland,Melek Rousian,Merle L de Zwart et al.
Naomi Graafland et al.
Introduction: The embryonic period in human development is the foundation of lifelong and even transgenerational health. Although previously believed to be uniform, there is increasing evidence that embryonic growth is in...