A2AR-phospho-STAT1 (Y701)-HLA-E axis as a potential immune modulatory pathway in radiotherapy-resistant triple negative breast cancer [0.03%]
放射抵抗性三阴乳腺癌中潜在的免疫调节通路A2AR-phospho-STAT1(Y701)-HLA-E轴的研究
Young Shin Ko,Hana Jin,So Eun Lee et al.
Young Shin Ko et al.
Triple-negative breast cancer (TNBC) patients have lower survival rates and higher recurrence risks than non-TNBC patients. Moreover, radiotherapy-resistant TNBC (RT-R-TNBC) exhibits enhanced chemotherapy resistance and invasiveness. Theref...
HS-10296 (Almonertinib) enhances radiosensitivity in EGFR-mutant NSCLC (including T790M) through inhibition of EGFR downstream signaling and DNA damage repair [0.03%]
HS-10296（阿尔莫苏替尼）通过抑制EGFR下游信号传导和DNA损伤修复增强对表皮生长因子受体突变型非小细胞肺癌的放射敏感性（包括T790M）
Weiqi Liu,Yulian Liu,Yun Xie et al.
Weiqi Liu et al.
Non-small cell lung cancer (NSCLC) harboring EGFR mutations, including the resistant T790M variant, continues to require improved therapeutic strategies despite the development of EGFR tyrosine kinase inhibitors (TKIs). This study evaluates...
Polo-like Kinase 4 (PLK4) as a Therapeutic Target in Breast Cancer [0.03%]
polo样激酶4(PLK4)作为乳腺癌治疗靶点的研究进展
Armen Parsyan,Harjot Athwal,Vasudeva Bhat et al.
Armen Parsyan et al.
Polo-like kinase 4 (PLK4) is a key kinase regulating centriole duplication, centrosome maturation, cytokinesis and other cellular processes. Growing evidence suggests a critical role of PLK4 in the development and progression of various can...
Thrombospondin-4 from Cancer-associated Fibroblasts Downregulates ERBB2 Expression in Gastric Cancer Cells [0.03%]
癌相关成纤维细胞来源的血小板源性生长因子通过下调胃癌细胞中ERBB2表达促进胃癌进展
Gen Tsujio,Masakazu Yashiro,Takashi Sakuma et al.
Gen Tsujio et al.
The intra-tumoral heterogeneity of HER2 expression is associated with resistance to anti-HER2 therapy in HER2-positive gastric cancers (GCs). We previously reported that thrombospondin-4 (THBS4) is overexpressed in cancer-associated fibrobl...
An update on the World Trade Center cancer tissue biobank: a scientific resource for molecular and mechanistic studies on WTC-related cancer [0.03%]
世界贸易中心癌症组织生物库的更新公告：一项关于9·11世界贸易中心事件相关癌症的分子和机制研究的科学资源
Wiley M Turner,Angelo Zegarelli,Tara Ivic-Pavlicic et al.
Wiley M Turner et al.
World Trade Center (WTC) responders were exposed to a complex mixture of toxins and carcinogens through dust, fumes, and smoke at ground zero. Since then, studies have indicated that WTC responders have elevated cancer rates compared to the...
The Oncogenic Role of AURKA in Gastric Cancer: Mechanisms, Pathways, and Clinical Relevance [0.03%]
AURKA在胃癌中的致癌作用：机制、途径及临床意义
Caixia Lv,Yan Liu,Huanhu Zhang
Caixia Lv
Aurora kinase A (AURKA) is a serine/threonine kinase that plays a critical role in cell cycle regulation, particularly during mitosis. Recent studies have identified AURKA as an oncogene overexpressed in various cancers, including gastric c...
Epithelial Ikkβ deletion modulates immune responses and the IFNγ/CXCL9 axis during early esophageal carcinogenesis [0.03%]
上皮Ikkβ缺失在早期食道癌变过程中调控免疫反应及IFNγ/CXCL9轴
Nathan Hodge,Marie-Pier Tétreault
Nathan Hodge
Esophageal cancer is a major cause of cancer-related death, often preceded with chronic inflammation and injuries. The NFκB/IKKβ pathway plays a central role in inflammation, yet its role in early esophageal carcinogenesis remains unclear...
Mammary Adipose Dysfunction in the Dual Epidemic of Obesity and Breast Cancer [0.03%]
肥胖和乳腺癌双重流行下的乳房脂肪组织功能异常
Elvina Jeyakumar,Sathyavathi Sundararaju,Stephanie Annett et al.
Elvina Jeyakumar et al.
Breast cancer is one of the leading causes of death among women, with obesity being a significant factor. Mammary adipose tissue (MAT) dysfunction in obesity creates a tumor-supportive environment, leading to increased risk. In obesity, MAT...
Associations of Pre-diagnostic Serum Liver Enzyme Levels with Lung Cancer Risk in Predominantly Low-income African and European Americans [0.03%]
低收入非洲人和欧洲人肺癌风险与血清肝酶水平之间的关系
Shuai Xu,Hui Cai,Jie Wu et al.
Shuai Xu et al.
Previous studies have linked liver diseases to lung cancer (LC) risk; however, few studies evaluated the associations of circulating liver enzyme levels with LC risk. We conducted a study of 353 incident LC cases and 646 matched controls wi...