Analysis of MRPL23 protein expression and its role in prostate cancer pathogenesis [0.03%]
MRPL23蛋白表达分析及其在前列腺癌发生发展中的作用研究
Edyta Podemska,Damian Łukasik,Jędrzej Borowczak et al.
Edyta Podemska et al.
Prostate cancer (PCa) is the fourth most commonly diagnosed malignancy worldwide and remains a major clinical challenge due to its heterogeneous course and lack of reliable prognostic biomarkers. Mitochondrial ribosomal protein L23 (MRPL23)...
LncRNA-encoded peptide LRRC75A-AS1-ORF3 suppresses anti-tumor immunity in colorectal cancer through mitophagy-mediated attenuation of cGAS-STING signaling [0.03%]
长链非编码RNA编码的肽LRRC75A-AS1-ORF3通过线粒体自噬介导的cGAS-STING信号抑制结直肠癌中的抗肿瘤免疫反应
Qi Wu,Zhun Li,Xinxin He et al.
Qi Wu et al.
Long non-coding RNAs (lncRNAs) serve as pivotal regulators of diverse physiological activities through their interactions with different biomolecules, and their aberrant expression frequently contributes to tumorigenesis and malignant progr...
Tumor-associated astrocytes inhibit tumor cell apoptosis through TNF-α-TNF receptor 2-NF-κB pathway in lung cancer brain metastasis [0.03%]
肿瘤相关星形胶质细胞通过TNF-α-TNF受体2-NF-κB途径抑制肺癌脑转移瘤细胞凋亡
Shuo Zhang,Jinjin Cai,Yingying Feng et al.
Shuo Zhang et al.
Lung cancer represents the leading cause of cancer-related mortality worldwide, with up to 50% of cases developing brain metastasis during disease progression. Current therapeutic options for brain metastasis remain limited, resulting in po...
Endoplasmic Reticulum Stress-Driven LncRNA Signature Predicts Cervical Cancer Prognosis and Guides Personalized Immunotherapy: A Multi-Omics and Functional Validation Study [0.03%]
基于内质网应激驱动的长链非编码RNA特征预测宫颈癌预后及指导个性化免疫治疗：多组学与功能验证研究
Jianchuan Hu,Zhongbing Qi,Shichuan Hu et al.
Jianchuan Hu et al.
Endoplasmic reticulum (ER) stress is a key driver of tumor progression and therapeutic resistance. However, the prognostic role of ER stress-related long non-coding RNAs (lncRNAs) in cervical cancer has not been systematically elucidated. I...
Non-Malignant Hematologic Conditions and Subsequent Cancer Risk: A Prospective Cohort Study and Mendelian Randomization Analysis [0.03%]
非恶性血液病与后续癌症风险的关系：一项前瞻性队列研究和孟德尔随机化分析
Weiwei Chen,Jiacong Li,Hengyu Cui et al.
Weiwei Chen et al.
No studies have examined the association between non-malignant hematologic diseases and the risk of various cancers. To examine the associations between non-malignant hematologic diseases and cancer risk, we performed a cohort study and men...
Utilizing the Life Span Study data in NASA astronaut cancer risk assessment [0.03%]
利用NASA航天员生命历程数据进行癌症风险评估
Luke Stegeman,Tony C Slaba,Janice L Huff et al.
Luke Stegeman et al.
During space missions, astronauts are continuously exposed to extraterrestrial radiation that differs in quality and dose rate compared with terrestrial radiation. As such, astronauts are considered special radiation workers and are subject...
Masahiro Nakashima,Hirokazu Kurohama,Yuko Akazawa
Masahiro Nakashima
Eighty years have passed since the atomic bombings (A-bombing) of Hiroshima and Nagasaki in August 1945. Survivors represent an unparalleled and irreplaceable human cohort for comprehensively studying the long-term carcinogenic effects of r...