Marilena V Iorio,Carlo M Croce
Marilena V Iorio
When, ∼20 years ago, investigators first determined that components of the genome considered nonfunctional had, in fact, gene regulatory capacity, they probably had no idea of their potential in controlling cell fate and were forced to rev...
Smoking, alcohol and colon cancer survival is modified by immune biomarkers: a population-representative study [0.03%]
吸烟、饮酒通过免疫生物标志物影响结直肠癌患者生存：基于人口的代表性研究
Yasemin Adali,Maurice B Loughrey,Stephanie Craig et al.
Yasemin Adali et al.
Lifestyle factors such as smoking and alcohol may influence colon cancer (CC) survival, but it is unclear whether their effects vary by tumour-infiltrating immune biomarkers. This study examined CC-specific survival by smoking and alcohol s...
MSH2 Prevents Liver Tumorigenesis by Regulating Cell Cycle Checkpoints under Chronic Inflammation [0.03%]
MSH2通过调节慢性炎症下的细胞周期检测点防止肝肿瘤发生
Shigeharu Nakano,Atsushi Takai,Eriko Iguchi et al.
Shigeharu Nakano et al.
The DNA mismatch repair (MMR) system plays a critical role in maintaining genomic integrity and preventing tumorigenesis. Although MutS homolog 2 (MSH2) is a key component of the MMR system and is dysregulated in human hepatocellular carcin...
Role of Colorectal Cancer-Derived Exosomes in Modulating Macrophage Phenotypes During Tumor Development [0.03%]
结直肠癌来源外泌体调节肿瘤发育过程中巨噬细胞表型的作用研究
Khandu Wadhonkar,Dhruv Das,Rajani Kant Chittela et al.
Khandu Wadhonkar et al.
Colorectal cancer (CRC) is one of the deadliest cancer types and is characterized by a complex tumor microenvironment (TME), which includes cancer and immune cells engaging in intricate signaling crosstalk. TME is dependent on the CRC stage...
Genomic and transcriptomic characterization of gamma ray- and heavy ion-induced precursor B-cell lymphomas in B6C3F1 mice: Radiation type-dependent interstitial chromosomal deletions at tumor-suppressor gene loci [0.03%]
γ射线和重离子诱导的B6C3F1小鼠前体B淋巴细胞瘤的基因组和转录组特征：放射类型依赖的肿瘤抑制基因位点染色体内缺失
Kenta Amano,Hirotaka Tachibana,Chizuru Tsuruoka et al.
Kenta Amano et al.
Epidemiological studies have revealed that ionizing radiation is a risk factor for acute lymphoblastic leukemia. Humans can be exposed to radiation via clinical radiotherapies or spaceflight, yet our knowledge of the potential carcinogenic ...
Plasma proteomic profiling identified prognostic indicators with therapeutic potential for colorectal cancer [0.03%]
血浆蛋白质组谱分析确定结直肠癌预后指标及治疗潜力
Xuan Xie,Jiahao Zhou,Qingbin Wu et al.
Xuan Xie et al.
Plasma proteins have been reported as predictors and potential targets for reducing colorectal cancer (CRC) risk. However, their potential roles in CRC prognosis remain unexplored. We measured plasma levels of 367 neuro-related proteins in ...
Anne M Bailey,Lorne J Hofseth
Anne M Bailey
Plastics have become integral to modern life, but their persistence has generated vast quantities of microplastics (MPs,
Zhimin Bai,Xiaoyu Huang,Hui Jia et al.
Zhimin Bai et al.
Chimeric antigen receptor (CAR-T) cell therapy has been widely used in haematological malignancies and has achieved remarkable results. However, two major toxicities of CAR-T-cell therapy, cytokine release syndrome (CRS) and immune effector...