Modulation of dietary methionine intake elicits potent, yet distinct, anticancer effects on primary versus metastatic tumors [0.03%]
饮食中的蛋氨酸摄入量的变化对原发和转移肿瘤产生不同却显著的抗癌效果
Isabelle R Miousse,Julia Tobacyk,Charles M Quick et al.
Isabelle R Miousse et al.
Methionine dependency describes the characteristic rapid in vitro death of most tumor cells in the absence of methionine. Combining chemotherapy with dietary methionine deprivation [methionine-deficient diet (MDD)] at tolerable levels has v...
A molecular mechanism of nickel (II): reduction of nucleotide excision repair activity by structural and functional disruption of p53 [0.03%]
镍(II)分子机制：通过结构和功能破坏p53减少核苷酸切除修复活性
Yeo Jin Kim,Young Ju Lee,Hyo Jeong Kim et al.
Yeo Jin Kim et al.
Nickel is a major carcinogen that is implicated in tumor development through occupational and environmental exposure. Although the exact molecular mechanisms of carcinogenesis by low-level nickel remain unclear, inhibition of DNA repair is ...
Jinyoung Byun,Ann G Schwartz,Christine Lusk et al.
Jinyoung Byun et al.
To identify genetic variation associated with lung cancer risk, we performed a genome-wide association analysis of 685 lung cancer cases that had a family history of two or more first or second degree relatives compared with 744 controls wi...
Oestrogen fuels the growth of endometrial hyperplastic lesions initiated by overactive Wnt/β-catenin signalling [0.03%]
雌激素促进过度活跃Wnt/β-catenin信号诱导的子宫内膜增生病灶生长
Jyoti Goad,Yi-An Ko,Manish Kumar et al.
Jyoti Goad et al.
Unopposed oestrogen is responsible for approximately 80% of all the endometrial cancers. The relationship between unopposed oestrogen and endometrial cancer was indicated by the increase in the number of endometrial cancer cases due to the ...
Dro1/Ccdc80 inactivation promotes AOM/DSS-induced colorectal carcinogenesis and aggravates colitis by DSS in mice [0.03%]
Dro1/Ccdc80缺失促进AOM/DSS诱导的小鼠结肠癌发生及DSS诱导的结肠炎恶化
Jessica I Grill,Jens Neumann,Andrea Ofner et al.
Jessica I Grill et al.
Colorectal carcinogenesis is a progressive multistep process involving the sequential accumulation of genetic alterations in tumor suppressor genes and oncogenes. Downregulated by oncogenes 1 (Dro1/Ccdc80) has been shown to be a potent tumo...
Alan Fu,Helena R Chang,Zuo-Feng Zhang
Alan Fu
Increasingly affordable high-throughput molecular profiling technologies have made feasible the measurement of omics-wide interindividual variations for the purposes of predicting cancer prognosis. While multiple types of genetic, epigeneti...
Deficiency of tumor suppressor Merlin facilitates metabolic adaptation by co-operative engagement of SMAD-Hippo signaling in breast cancer [0.03%]
肿瘤抑制因子Merlin缺乏通过SMAD-Hippo信号协同作用促进乳腺癌的代谢适应性
Mateus S V Mota,William P Jackson,Sarah K Bailey et al.
Mateus S V Mota et al.
The NF2 gene encodes the tumor and metastasis suppressor protein Merlin. Merlin exerts its tumor suppressive role by inhibiting proliferation and inducing contact-growth inhibition and apoptosis. In the current investigation, we determined ...
Common genetic variants associated with pancreatic adenocarcinoma may also modify risk of pancreatic neuroendocrine neoplasms [0.03%]
与胰腺导管腺癌相关的常见遗传变异可能也会影响胰腺神经内分泌肿瘤的风险
Ofure Obazee,Gabriele Capurso,Francesca Tavano et al.
Ofure Obazee et al.
Published Erratum
Carcinogenesis. 2018 Jul 3;39(7):969. DOI:10.1093/carcin/bgy067 2018
MicroRNA-31 reflects IL-6 expression in cancer tissue and is related with poor prognosis in bile duct cancer [0.03%]
微 RNA-31反映癌症组织中的IL-6表达并与胆道癌的预后不良有关
Keisuke Ishigami,Katsuhiko Nosho,Hideyuki Koide et al.
Keisuke Ishigami et al.
Bile duct cancer is a highly aggressive malignancy wherein early diagnosis is difficult and few treatment options are available. MicroRNA-31 (miR-31) is reported to be related with survival in patients with gastrointestinal cancers; however...
Curcumin induces a fatal energetic impairment in tumor cells in vitro and in vivo by inhibiting ATP-synthase activity [0.03%]
姜黄素通过抑制ATP合酶活性在体内和体外诱导肿瘤细胞致命的能量障碍
Giovanna Bianchi,Silvia Ravera,Chiara Traverso et al.
Giovanna Bianchi et al.
Curcumin has been reported to inhibit inflammation, tumor growth, angiogenesis and metastasis by decreasing cell growth and by inducing apoptosis mainly through the inhibition of nuclear factor kappa-B (NFκB), a master regulator of inflamm...