Δ133p53 isoform enhances TLR4 function to promote tumour growth [0.03%]
Delta133p53异构体通过增强TLR4功能来促进肿瘤生长
Sasini Polwatta Lekamlage,Alexandra N Boix De Jesus,Adriana Machado Saraiva et al.
Sasini Polwatta Lekamlage et al.
Tumour protein 53 (TP53) acts as a tumour suppressor and is often mutated in cancer. Isoforms of TP53, such as the Δ133p53 family, can promote tumour growth and metastasis. Therefore, targeting Δ133p53 function may represent a new strateg...
A novel serum biomarker Enhancer RNA RASSF8-AS1 promotes the progression of gastric cancer [0.03%]
新型血清生物标志物Enhancer RNA RASSF8-AS1促进胃癌进展
Xun Li,Xiaojue Chen,Bairong Chen et al.
Xun Li et al.
Gastric cancer (GC) is globally recognized as one of the most widespread malignant tumors. As the symptoms of patients with early GC are ambiguous, the majority of patients are given a diagnosis of advanced GC. Therefore, this necessitates ...
Expression profile of claudin 3, 4, and 7 in breast tumours and its correlation with clinicopathological features [0.03%]
Claudin 3、4和7在乳腺肿瘤中的表达谱及其与临床病理特征的相关性
Reena Yadav,Sumit Goel,Laxmi Kumari et al.
Reena Yadav et al.
Claudins, integral components of tight junctions, play a pivotal role in maintaining cellular adhesion and polarity. Aberrant expression of claudins has been implicated in the progression of various malignancies, including breast cancer (BC...
HECTD3 E3 ligase mediates ubiquitination of AKT-phosphorylated CMTM3 in HER2-overexpressed breast cancer cells [0.03%]
乳腺癌细胞中HECTD3 E3泛素连接酶介导AKT磷酸化CMTM3的泛素化作用
Jun Wang,Delong Wang,Xinxing Zhang et al.
Jun Wang et al.
CMTM (CKLF-like MARVEL transmembrane domain-containing) proteins play pivotal roles in tumorigenesis and cancer progression across various malignancies. However, their expression profiles and regulatory mechanisms in distinct subtypes of br...
Core Transcriptional Regulatory Circuit-Regulated IGF2BP3 Stabilizes E2F2 mRNA via m6A Modification in Neuroblastoma [0.03%]
核心转录调控回路调控的IGF2BP3通过m6A修饰稳定神经母细胞瘤中的E2F2 mRNA
Pengcheng Yang,Jianwei Wang,Ziheng Wu et al.
Pengcheng Yang et al.
Neuroblastoma (NB) is a pediatric tumor with diverse outcomes and unknown underlying mechanisms. The core transcriptional regulatory circuit (CRC) and N6-methyladenosine (m6A) are key factors that control cell identity and fate. IGF2BP3 is ...
FZD6 promotes 5-fluorouracil resistance through inhibiting pyroptosis in colorectal cancer [0.03%]
FZD6通过抑制焦亡促进结直肠癌耐药性
Zilong He,Jing Yang,Yu Zhang et al.
Zilong He et al.
Resistance to 5-fluorouracil (5-FU) causes treatment failure in most colorectal cancer (CRC) cases. Pyroptosis is associated with chemotherapy resistance, although its role in 5-FU resistance in CRC is not well understood. To investigate th...
BRINP3 promotes lung adenocarcinoma by enhancing CLOCK-mediated transcriptional regulation of CRYZL1 and activating the AKT pathway [0.03%]
BRINP3通过增强CLOCK介导的CRYZL1转录调控并激活AKT通路来促进肺腺癌发展
Ye Zhang,Cheng Huang,Yeye Chen et al.
Ye Zhang et al.
Lung cancer, particularly lung adenocarcinoma (LUAD), is the leading cause of cancer-related death globally. This study investigated the role of BRINP3 in LUAD. Immunohistochemical analysis revealed significantly upregulated BRINP3 expressi...
Co-Targeting KRASG12D and the HER family is efficacious in colorectal cancer [0.03%]
KRASG12D与HER家族联合靶向治疗在结直肠癌中有效
Mary Kate Kilroy-Gehret,Cecilia Wischmeier,SoYoung Park et al.
Mary Kate Kilroy-Gehret et al.
Colorectal cancer (CRC) is the second leading cause of cancer deaths worldwide, with roughly 41% of CRC cases harboring a KRAS mutation. Acquired resistance to KRAS-targeted treatments has occurred with mechanisms including increased HER fa...
Constitutive Epidermal Expression of Osteopontin in Osteopontin-Null Mice Restores Ultraviolet B-Induced Cutaneous Squamous Cell Carcinomas to Wild-Type Levels [0.03%]
在骨涎蛋白基因敲除小鼠中构成型表皮表达骨涎蛋白可使其紫外线诱导的皮肤鳞状细胞癌发病率恢复至正常水平
Chu-Fang Chou,Yun Huang,Jeremy B Foote et al.
Chu-Fang Chou et al.
Studies of osteopontin (OPN)-null mice have supported the role of OPN as a critical factor in the promotion of skin tumorigenesis. OPN is a highly inducible integrin- and CD44-interacting acidic glycoprotein with pleiotropic functions. In v...
Genome-wide association study of early-stage non-small cell lung cancer prognosis: a pooled analysis in the International Lung Cancer Consortium [0.03%]
国际肺癌联盟中关于早期非小细胞肺癌预后的全基因组关联研究：合并分析
Mei Dong,Abhinav Thakral,Karl Smith- Byrne et al.
Mei Dong et al.
Lung cancer is the leading cause of cancer mortality. To investigate genetic determinants for prognosis among patients diagnosed with early-stage non-small cell lung cancer (NSCLC), we conducted the first large-scale genome-wide association...