Therapeutic drug monitoring and target attainment of unbound flucloxacillin in hospitalized patients with measured MICs (FLUTE) [0.03%]
测定MIC的住院患者的药物浓度监测和达到有效浓度的未结合夫西地酸的研究（FLUTE研究）
Pjotr P Temme,Elsbeth J Nagtegaal,Rocío M Ramos Díaz et al.
Pjotr P Temme et al.
Objectives: To determine the proportion of patients achieving target attainment of unbound flucloxacillin in blood plasma, evaluate the association between unbound flucloxacillin concentration and toxicity and identify pa...
One resistance gene, many transposons: repeated formation of compound and pseudo-compound transposons carrying the aphA1 kanamycin and neomycin resistance gene [0.03%]
一个抗性基因多个转座子：aphA1卡那霉素和新霉素抗性基因多次形成复合型和假复合型转座子
Christopher J Harmer,Ruth M Hall
Christopher J Harmer
Efflux-mediated multidrug resistance mechanism in Trichophyton indotineae and Trichophyton rubrum; role of ABC transporters and MFS gene [0.03%]
表皮癣菌和须癣菌的多药耐药外排机制；ABC转运蛋白和MFS基因的作用
Dipika Shaw,Sheetal Thakur,Anup Ghosh et al.
Dipika Shaw et al.
Background: An unprecedented surge in chronic, recalcitrant, and resistant dermatophytosis has been observed, predominantly caused by Trichophyton indotineae. While terbinafine resistance is usually linked to squalene epo...
In vitro exebacase (CF-301) activity against methicillin-susceptible or methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci strains isolated from patients with infective endocarditis [0.03%]
体外实验评价exebacase(CF-301)对感染性心内膜炎患者分离的金黄色葡萄球菌(苯唑西林敏感或耐药株)和凝固酶阴性葡萄球菌的活性
María-Alexandra Cañas,Guillermo Cuervo,Javier García-González et al.
María-Alexandra Cañas et al.
Background: Infective endocarditis (IE) is a severe infection mainly caused by Staphylococcus aureus, Enterococcus faecalis and viridans streptococci. Coagulase-negative staphylococci (CoNS), especially methicillin-resist...
Nanoparticle-based co-delivery of ciprofloxacin and meropenem enhances synergistic activity against multidrug-resistant hypervirulent Klebsiella pneumoniae clinical isolates [0.03%]
基于纳米颗粒的环丙沙星和美罗培南联合递送可增强对多重耐药高毒力肺炎克雷伯菌临床分离株的协同作用
Reham Mostafa,Shereen Mohammed,Ahmed S Ahmed et al.
Reham Mostafa et al.
Background: Despite the growing concern over MDR hypervirulent Klebsiella pneumoniae (MDR-hvKP), effective treatments remain limited. Aim: ...
Reducing aztreonam/avibactam waste: insights from Monte Carlo simulations [0.03%]
降低aztreonam/avibactam浪费：来自蒙特卡洛模拟的见解
Yeleen Fromage,Hamza Sayadi,Marc Labriffe et al.
Yeleen Fromage et al.
Background: The fixed-dose combination of aztreonam/avibactam is administered with a loading dose (LD), resulting in systematic drug wastage in patients with preserved renal function. Whether the LD can be reduced remains...
Sphingobacterium spp. as intrinsic producers of SPI Ambler class B metallo-β-lactamases [0.03%]
鞘杆菌属固有产生新型SPI Ambler类碳青霉烯酶
Delphine Girlich,Cécile Emeraud,Aymeric Jacquemin et al.
Delphine Girlich et al.
Objectives: To characterize the intrinsic carbapenemase of Sphingobacterium spp. Materials and methods: Sphingobacterium spp. clinical ...
Acquired antimicrobial resistance genes in Bordetella Species: a global genomic analysis [0.03%]
百日咳博德特氏菌属的获得性抗菌药物抗性基因：一项全球基因组分析
Biao Tang,Xiaohe Hu,Yu Song et al.
Biao Tang et al.
Background: The genus Bordetella comprises Gram-negative pathogens, notably B. pertussis, which causes whooping cough, underscoring the need to characterize antimicrobial resistance (AMR) within this group. However, repor...
Development of population pharmacokinetic models of total and free piperacillin in critically ill children and young adults for Monte Carlo simulations and model-informed precision dosing [0.03%]
用于蒙特卡洛模拟和基于模型的精确给药的重症儿童及青年人群中哌拉西林总浓度与游离浓度人群药代动力学模型的发展
Sonya Tang Girdwood,H Rhodes Hambrick,Ronaldo Morales Junior et al.
Sonya Tang Girdwood et al.
Objectives: We sought to develop population pharmacokinetic (PopPK) models of total and free piperacillin in critically ill children and young adults. We investigated the impact of kidney function and injury biomarkers an...
Epidemiology and treatment of endocarditis secondary to Enterobacterales other than Serratia spp [0.03%]
肠杆菌目（阴沟肠杆菌除外）感染性心内膜炎的流行病学和治疗
Clayton F Hausberger,Lingyi Peng,G K Balasubramani et al.
Clayton F Hausberger et al.
Objective: To investigate the epidemiology and outcomes of patients with non-Serratia Enterobacterales endocarditis. Methods: Adult pat...