NGFR induces melanoma invasion and immunotherapy resistance through myosin light chain 2 modulation [0.03%]
神经生长因子受体通过肌球蛋白轻链2调节诱导黑素瘤侵袭和免疫疗法耐药性
Laura Nogués,Vanesa Santos,Juan García-Agullo et al.
Laura Nogués et al.
Immunotherapy has reshaped melanoma treatment, yet the majority of patients fail to respond or develop resistance. Nerve growth factor receptor (NGFR/p75NTR/CD271) has been linked to melanoma aggressiveness and therapeutic resistance, but t...
Transmembrane domain switching controls PINK1 import and fate in mitochondria [0.03%]
跨膜区转换控制Pink1的线粒体导入及其命运
James S Lorriman,Rhiannon J Hughes,Adam G Grieve et al.
James S Lorriman et al.
Mitochondrial targeting of the PINK1 kinase results, under normal conditions, in membrane-potential-driven inner membrane penetration and cleavage by the resident protease PARL before retro-translocation and proteasomal degradation. In comp...
Genetic ablation of neuronal mitochondrial calcium uptake impedes Alzheimer's disease progression [0.03%]
遗传性神经元线粒体钙摄取消融可延缓阿尔茨海默病进展
Pooja Jadiya,Elena Berezhnaya,Devin W Kolmetzky et al.
Pooja Jadiya et al.
Loss of mCa2+ efflux capacity contributes to the pathogenesis and progression of Alzheimer's disease (AD) by promoting mitochondrial Ca2+ (mCa2+) overload. Here, we utilized loss-of-function genetic mouse models to causally evaluate the rol...
Interspecific diversity in the neuronal composition of the mammalian cortex arises from heterochrony in neurogenesis [0.03%]
哺乳动物皮层神经元组成的物种多样性由神经发生过程中的异时性造成
Yuki Y Yamauchi,Xuanhao D Sheu,Rafat Tarfder et al.
Yuki Y Yamauchi et al.
Mammals share a laminar cerebral cortex, with excitatory neuron subtypes organized in distinct layers. Although this framework is conserved, subtype balance varies markedly between species due to largely unknown mechanisms. Here, we show th...
20S proteasome-regulated proteostasis in ELVAs is critical for oocyte-to-embryo transition and female fertility [0.03%]
20S蛋白酶体调控的蛋白质稳态对卵母细胞到胚胎过渡及雌性生殖力至关重要
Yan Rong,Yingyan Chen,Huiwen Cao et al.
Yan Rong et al.
Programmed degradation of maternal proteins is essential for the oocyte-to-embryo transition (OET). While pharmacological inhibition studies have established the importance of proteasomes in ovarian reserve maintenance, oocyte maturation an...
Runhan Li,Jingyun Zhang,Kehang Mao et al.
Runhan Li et al.
Skin aging, the most visible and accessible manifestation of organismal aging, reflects systemic physiological decline, compromising barrier integrity, immune defense, and regenerative capacity-functions essential for overall tissue homeost...
Autoinhibitory feedback preserves intestinal stem cell maintenance and fate commitment [0.03%]
自抑制反馈保留肠道干细胞的维持和命运决定
Siamak Redhai,Nick Hirschmüller,Tianyu Wang et al.
Siamak Redhai et al.
Intestinal stem cells (ISCs) continuously renew the gut epithelium by producing specialised cell types, yet the mechanisms that couple ISC renewal with lineage commitment remain poorly characterised. Here, we identify a self-limiting transc...
Atg18 interaction positions Atg2 for efficient lipid transfer into phagophore elongation [0.03%]
Atg18与Atg2互作以高效促进脂质向吞噬体延伸部位转移
Sabrina Chumpen Ramirez,Dmitry Shvarev,Prado Vargas Duarte et al.
Sabrina Chumpen Ramirez et al.
During macroautophagy, the de novo formation of the autophagosome at a membrane contact site (MCS) with the endoplasmic reticulum requires directional lipid flux for the growth of the initial phagophore before its sealing into an autophagos...
A new plant SUMO ligase, MPEL1, synergizes with MAPK16 to regulate resistance against Fusarium pathogens [0.03%]
一种新的植物SUMO连接酶MPEL1通过与MAPK16协同作用调节对尖孢镰刀菌属病原体的抗性
Xuanjun Feng,Weixiao Zhang,Huarui Guan et al.
Xuanjun Feng et al.
SUMOylation is critical for plant growth and defense, and the specific substrate recognition mediated by SUMO ligases dictates the biological processes in which SUMOylation functions. However, only four SUMO ligases involved in SUMOylation ...
A Rab/Kinesin-12/kinase module couples vesicle delivery and phragmoplast dynamics during plant cell cytokinesis [0.03%]
Rab/动力蛋白-12/激酶模块在植物细胞胞质分裂过程中连接囊泡运输和细胞板动态变化
Liam Elliott,Moé Yamada,Monika Kalde et al.
Liam Elliott et al.
Cytokinesis is a key process in the development of multicellular organisms, through both formative and proliferative divisions. In land plants, successful cytokinesis requires precise targeting of Golgi-derived vesicles to the future cell d...