Anchoring of perforin-2 via the transmembrane domain is required for antigen escape into the cytosol [0.03%]
穿膜区定位的穿孔素-2对于抗原逃逸到细胞质中是必需的
Marco Laub,Ritika Chatterjee,Patrycja Kozik
Marco Laub
Perforin-2 is a pore-forming protein localised to the endocytic compartments of dendritic cells and macrophages. It is reported to perform two distinct functions during immune responses: attacking intravacuolar pathogens, and forming pores ...
Disease-specific tau polymorphs are associated with unique protein networks across proteinopathies [0.03%]
特定疾病的tau蛋白多态与蛋白质病原体中的独特蛋白网络相关
Nicha Puangmalai,Nemil Bhatt,Nopparat Suthprasertporn et al.
Nicha Puangmalai et al.
Tau protein aggregates adopt distinct conformations across tauopathies, yet the protein interactions engaged by disease-specific polymorphs remain poorly characterized. Here, we demonstrate that conformationally distinct tau polymorphs asso...
Canonical and non-canonical miRNA degradation shapes state transitions and stemness in breast cancer [0.03%]
经典与非经典miRNA降解调控乳腺癌细胞状态转换和干细胞属性
Carmela Rubolino,Manfredi D&#x;Onghia,Chiara Tordonato et al.
Carmela Rubolino et al.
Target-directed microRNA degradation (TDMD) is an emerging post-transcriptional mechanism that controls miRNA turnover, yet its role in human cancers remains largely unexplored. Here, we combine CRISPRi-mediated ZSWIM8 depletion, miRNA-seq,...
Reconstitution of glycan-driven MHC-I recycling reveals calreticulin as mediator between TAPBPR and tapasin [0.03%]
关于糖链驱动的MHC-I再循环的重构揭示出了TAPBPR和tapasin之间的腔内钙连蛋白介导作用
Tim J Heinke,Amin Fahim,Niko Popovic et al.
Tim J Heinke et al.
Protein folding in the endoplasmic reticulum (ER) relies on N-linked glycosylation and glycan remodeling to guide quality control. Major histocompatibility complex class I (MHC-I) molecules, essential for adaptive immunity, undergo a specia...
Alexandra Drakaki,Josje M A Huisman,Marten A Hoeksema
Alexandra Drakaki
Macrophages can adopt diverse functional states in response to environmental cues, a process that is fundamentally controlled at the level of transcriptional regulation. In this review, we outline a hierarchical framework of transcription f...
Chromatin condensates tune nuclear mechanosensing and preserve nuclear integrity to prevent cGAS activation [0.03%]
染色质凝聚体调节核机械感受并维护核完整性以防止cGAS活化
Sarah D&#x;Annunzio,Martina Di Santo,Giulia Vitali et al.
Sarah D&#x;Annunzio et al.
Cells and tissue integrity are constantly challenged by the necessity to adapt and respond to mechanical loads. Among cellular components, the nucleus possesses mechano-sensing and mechanotransduction capabilities, yet the molecular mechani...
In-situ cryo-ET of mouse embryos reveals cytoplasmic lattices contain ubiquitin-charged E2-E3 ligase assemblies [0.03%]
对小鼠胚胎进行原位低温电子层析成像鉴定出细胞质晶格包含泛素化的E2-E3连接酶复合体
Kashish Singh,Katarina Harasimov,Kathy K Niakan et al.
Kashish Singh et al.
Cytoplasmic lattices (CPLs) are filamentous assemblies essential for mammalian embryonic development. They are known to regulate organelle organization, spindle assembly, and protein homeostasis, but their molecular functions remain unclear...
Allosteric switching of Ca2+ permeability in the lysosomal ion channel TPC2 underpins biased agonist activation [0.03%]
钙离子在溶酶体通道TPC2中的别构调控机制是偏置激动剂激活的基础
Qianru Mu,Ryo Saito,Franceska Ozola et al.
Qianru Mu et al.
Ion channels possess selectivity filters that are hardwired to ensure the selective passage of ions. Lysosomal two-pore channels are unusual as they are able to switch their cation selectivity in an agonist-specific manner, allowing differe...
Pho84/GLUT2 are cellular myo-inositol exporters regulated by inositol pyrophosphates [0.03%]
肌醇焦磷酸盐调节的细胞肌醇出口蛋白Pho84/GLUT2
Xue Bessie Su,Xinjie Zhang,Valeria Fedeli et al.
Xue Bessie Su et al.
Inositol is an essential nutrient for most living organisms, as combinatorial phosphorylation on this cyclic sugar generates key cellular messengers, such as lipid-bound phosphoinositides (PtdInsPs), water-soluble inositol phosphates (InsPs...
P-selectin delineates conserved functional heterogeneity in early hematopoietic stem cell aging in humans and mice [0.03%]
P-选择素揭示了人类和小鼠早期造血干细胞衰老中保守的功能异质性
Chong Yang,Tong Wang,Yue Chai et al.
Chong Yang et al.
Progressive aging of bone marrow hematopoietic stem cells (HSCs) underlies clonal hematopoiesis and age-associated hematologic disorders. Defining early molecular events driving HSC functional decline is essential for rejuvenation strategie...