Disruption of ER-mitochondria contact sites by coronavirus replication organelles sustains viral replication via NSP3 stabilization [0.03%]
冠状病毒复制小体通过稳定NSP3干扰内质网-线粒体接触点以维持病毒复制
Xinyue Zheng,Liqiao Hu,Xubing Long et al.
Xinyue Zheng et al.
Coronaviruses establish infection by reorganizing the host endoplasmic reticulum (ER) to form double-membrane vesicles (DMVs), which function as viral replication platforms. However, the role of other cellular organelles in this process rem...
Mitochondrial NADH-redox inflexibility constrains genomic and epigenetic stability in pluripotent stem cells [0.03%]
线粒体NADH氧化还原反应的不灵活性限制了多能干细胞中的基因组和表观遗传稳定性
Tanveer Ahmed,Hui Zhang,Ghulam M Mushraf et al.
Tanveer Ahmed et al.
The electron transport chain (ETC) is essential for NAD+ regeneration and proliferation. While many cell types tolerate ETC inhibition when pyruvate or aspartate is supplied, pluripotent stem cells (PSCs) enter a reversible paused state eve...
Phosphorylation tunes strain-specific protein condensation during rotavirus replication organelle assembly [0.03%]
磷酸化调节轮状病毒复制器官装配过程中应变特异性蛋白凝聚体的形成
Julia Acker,Xinyu Wang,Alonso J Pardal et al.
Julia Acker et al.
In many viruses, intrinsically disordered proteins (IDPs) drive the formation of replicative organelles via liquid-liquid phase separation (LLPS). In species A rotaviruses, the disordered protein NSP5 forms condensates with NSP2, but its hi...
FAM134B-mediated ER-phagy degrades APP and suppresses Alzheimer's disease pathology [0.03%]
FAM134B介导的内质网自噬降解APP并抑制阿尔茨海默病病理变化
Yuting Zhang,Jun Sun,Yang Cai et al.
Yuting Zhang et al.
Endoplasmic reticulum autophagy (ER-phagy) is a selective autophagy pathway in which receptor proteins target ER membranes and proteins for degradation, yet its role in Alzheimer's disease (AD) remains unclear. Here, we identify FAM134B/RET...
Structure and function of a fungal AB toxin-like chimerolectin involved in anti-nematode defense [0.03%]
一种参与抗线虫防御的类似真菌AB毒素的嵌合凝集素的结构和功能
Stefanie S Schmieder,Gabriele Cordara,Flore Kersten et al.
Stefanie S Schmieder et al.
Fungal defense against predators largely relies on protein toxins, many of which are lectins. We previously showed that the production of the nematotoxin CCTX2 is upregulated in the Agaricomycete Coprinopsis cinerea upon predation by nemato...
Mechanosensitive FHL2 tunes endothelial function via microtubule-actomyosin crosstalk [0.03%]
机械敏感性FHL2通过微管肌动蛋白交叉 talk 调节内皮功能
Shailaja Seetharaman,John Devany,Ha Ram Kim et al.
Shailaja Seetharaman et al.
Endothelial tissues are essential mechanosensors in the vasculature, and defects in their response to mechanical cues such as blood flow can lead to endothelial dysfunction and cardiovascular diseases like atherosclerosis. Here, we explore ...
RNA helicase DHX29 controls the translation of transcription factors involved in germinal center response and plasma cell differentiation in mice [0.03%]
RNA解旋酶DHX29通过控制参与生发中心反应和浆细胞分化转录因子的翻译在小鼠中发挥调控作用
Jiayi Zhao,Xiaoyu He,Peicheng Hong et al.
Jiayi Zhao et al.
The roles of translational control in the immune system are incompletely understood. Using a CRISPR/Cas9-mediated functional screen of RNA helicases in an in vitro system of plasma cell differentiation, we identify in this study DHX29 as a ...
NGFR induces melanoma invasion and immunotherapy resistance through myosin light chain 2 modulation [0.03%]
神经生长因子受体通过肌球蛋白轻链2调节诱导黑素瘤侵袭和免疫疗法耐药性
Laura Nogués,Vanesa Santos,Juan García-Agullo et al.
Laura Nogués et al.
Immunotherapy has reshaped melanoma treatment, yet the majority of patients fail to respond or develop resistance. Nerve growth factor receptor (NGFR/p75NTR/CD271) has been linked to melanoma aggressiveness and therapeutic resistance, but t...
Transmembrane domain switching controls PINK1 import and fate in mitochondria [0.03%]
跨膜区转换控制Pink1的线粒体导入及其命运
James S Lorriman,Rhiannon J Hughes,Adam G Grieve et al.
James S Lorriman et al.
Mitochondrial targeting of the PINK1 kinase results, under normal conditions, in membrane-potential-driven inner membrane penetration and cleavage by the resident protease PARL before retro-translocation and proteasomal degradation. In comp...
Genetic ablation of neuronal mitochondrial calcium uptake impedes Alzheimer's disease progression [0.03%]
遗传性神经元线粒体钙摄取消融可延缓阿尔茨海默病进展
Pooja Jadiya,Elena Berezhnaya,Devin W Kolmetzky et al.
Pooja Jadiya et al.
Loss of mCa2+ efflux capacity contributes to the pathogenesis and progression of Alzheimer's disease (AD) by promoting mitochondrial Ca2+ (mCa2+) overload. Here, we utilized loss-of-function genetic mouse models to causally evaluate the rol...