Author Correction: Beyond quality control: biological roles of nonsense-mediated RNA decay [0.03%]
作者更正：超越质量控制：无意义介导的RNA衰减的生物学作用
Kun Tan,Miles F Wilkinson
Kun Tan
Published Erratum
The EMBO journal. 2026 Jun 2. DOI:10.1038/s44318-026-00822-z 2026
Tvp complexes support formation of the VgrG-PAAR spike during Type VI secretion system assembly [0.03%]
TVP复合物支持VI型分泌系统装配过程中VgrG-PAAR刺突的形成
Laura Monlezun,Christopher Earl,Sarah J Coulthurst
Laura Monlezun
Type VI secretion systems (T6SSs) are nanomachineries used by bacteria to inject toxic effectors into neighbouring cells during interbacterial competition or infection. Distinct paralogues of the structural proteins VgrG and PAAR and specif...
The C9orf72/SMCR8 complex maintains microglial homeostasis via RAB8A-ESCRT-mediated lysosomal repair [0.03%]
C9orf72/SMCR8复合物通过RAB8A-ESCRT介导的溶酶体修复维持小胶质细胞稳态
Shan Li,Shidong Xu,Feng Li et al.
Shan Li et al.
Microglia are critical regulators of neuroinflammation and neurodegeneration. Haploinsufficiency of C9orf72, the most frequently mutated gene in amyotrophic lateral sclerosis and frontotemporal dementia, has been linked to autophagy-lysosom...
Disruption of ER-mitochondria contact sites by coronavirus replication organelles sustains viral replication via NSP3 stabilization [0.03%]
冠状病毒复制小体通过稳定NSP3干扰内质网-线粒体接触点以维持病毒复制
Xinyue Zheng,Liqiao Hu,Xubing Long et al.
Xinyue Zheng et al.
Coronaviruses establish infection by reorganizing the host endoplasmic reticulum (ER) to form double-membrane vesicles (DMVs), which function as viral replication platforms. However, the role of other cellular organelles in this process rem...
Mitochondrial NADH-redox inflexibility constrains genomic and epigenetic stability in pluripotent stem cells [0.03%]
线粒体NADH氧化还原反应的不灵活性限制了多能干细胞中的基因组和表观遗传稳定性
Tanveer Ahmed,Hui Zhang,Ghulam M Mushraf et al.
Tanveer Ahmed et al.
The electron transport chain (ETC) is essential for NAD+ regeneration and proliferation. While many cell types tolerate ETC inhibition when pyruvate or aspartate is supplied, pluripotent stem cells (PSCs) enter a reversible paused state eve...
Phosphorylation tunes strain-specific protein condensation during rotavirus replication organelle assembly [0.03%]
磷酸化调节轮状病毒复制器官装配过程中应变特异性蛋白凝聚体的形成
Julia Acker,Xinyu Wang,Alonso J Pardal et al.
Julia Acker et al.
In many viruses, intrinsically disordered proteins (IDPs) drive the formation of replicative organelles via liquid-liquid phase separation (LLPS). In species A rotaviruses, the disordered protein NSP5 forms condensates with NSP2, but its hi...
FAM134B-mediated ER-phagy degrades APP and suppresses Alzheimer's disease pathology [0.03%]
FAM134B介导的内质网自噬降解APP并抑制阿尔茨海默病病理变化
Yuting Zhang,Jun Sun,Yang Cai et al.
Yuting Zhang et al.
Endoplasmic reticulum autophagy (ER-phagy) is a selective autophagy pathway in which receptor proteins target ER membranes and proteins for degradation, yet its role in Alzheimer's disease (AD) remains unclear. Here, we identify FAM134B/RET...
Structure and function of a fungal AB toxin-like chimerolectin involved in anti-nematode defense [0.03%]
一种参与抗线虫防御的类似真菌AB毒素的嵌合凝集素的结构和功能
Stefanie S Schmieder,Gabriele Cordara,Flore Kersten et al.
Stefanie S Schmieder et al.
Fungal defense against predators largely relies on protein toxins, many of which are lectins. We previously showed that the production of the nematotoxin CCTX2 is upregulated in the Agaricomycete Coprinopsis cinerea upon predation by nemato...
Mechanosensitive FHL2 tunes endothelial function via microtubule-actomyosin crosstalk [0.03%]
机械敏感性FHL2通过微管肌动蛋白交叉 talk 调节内皮功能
Shailaja Seetharaman,John Devany,Ha Ram Kim et al.
Shailaja Seetharaman et al.
Endothelial tissues are essential mechanosensors in the vasculature, and defects in their response to mechanical cues such as blood flow can lead to endothelial dysfunction and cardiovascular diseases like atherosclerosis. Here, we explore ...
RNA helicase DHX29 controls the translation of transcription factors involved in germinal center response and plasma cell differentiation in mice [0.03%]
RNA解旋酶DHX29通过控制参与生发中心反应和浆细胞分化转录因子的翻译在小鼠中发挥调控作用
Jiayi Zhao,Xiaoyu He,Peicheng Hong et al.
Jiayi Zhao et al.
The roles of translational control in the immune system are incompletely understood. Using a CRISPR/Cas9-mediated functional screen of RNA helicases in an in vitro system of plasma cell differentiation, we identify in this study DHX29 as a ...