SPACA9 and MNMIP1 bridge the seam of spermatid manchette microtubules [0.03%]
SPACA9和MNMIP1连接精子细胞小带微管的缝合线
Jo H Judernatz,Svetlana Doroshev,Robin A Hoogebeen et al.
Jo H Judernatz et al.
The manchette is a transient microtubule (MT)-based structure that is vital for the correct shaping of sperm during spermiogenesis. Throughout spermiogenesis, the manchette retains structural integrity for several days, raising the question...
GBP1 recruitment to actin-rich pedestals of extracellular Gram-negative bacteria promotes pyroptosis [0.03%]
GBP1募集到胞外革兰氏阴性细菌富肌动蛋白基底座上促进焦亡发生
Daniel J Bennison,Ishaan Chaudhary,Dharitri Chaudhuri et al.
Daniel J Bennison et al.
The IFNγ-induced GTPase guanylate-binding protein 1 (GBP1) binds to lipopolysaccharide (LPS) on cytosolic gram-negative bacteria and promotes pyroptosis via the recruitment and activation of caspase-4 on the bacterial outer membrane. Enter...
A DNA damage-activated kinase phosphorylates a transcriptional repressor to control bacterial immune pathway expression [0.03%]
一种DNA损伤活化的激酶通过磷酸化一个转录抑制因子来调控细菌免疫途径的表达
Lydia R Chambers,Phoolwanti Rani,Ryan K Min et al.
Lydia R Chambers et al.
Bacteria encode numerous stress-response pathways that protect their hosts against both internal and external threats. A key question is how these pathways are regulated, especially anti-phage immune pathways that mediate host-cell killing....
A coordinated transcriptional program controls de novo Golgi biogenesis [0.03%]
一个协调的转录程序控制从头高尔基体生物生成
Francesca Forno,Domenico Abete,Elena V Polishchuk et al.
Francesca Forno et al.
The Golgi apparatus expands during differentiation and increased secretory demand, yet the transcriptional mechanisms governing its biogenesis remain poorly defined. To investigate this process, we developed an enzymatic approach to ablate ...
Human immunosuppressive neutrophils: recent answers to old and new questions [0.03%]
人类免疫抑制性中性粒细胞：旧问题和新问题的最新答案
Patrizia Scapini,Chiara Lattanzi,Sven Brandau et al.
Patrizia Scapini et al.
Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) represent the most investigated type of "immunosuppressive" neutrophils in humans. However, a detailed understanding of human PMN-MDSCs has been hindered for years by limited kn...
MORC3 represses a tandem repeat enhancer to regulate interferon [0.03%]
MORC3通过抑制串联重复增强子来调节I型干扰素基因的表达
Luisa Krumwiede,David Hollaus,Erika Valeri et al.
Luisa Krumwiede et al.
The antiviral protein MORC3 is frequently inhibited by viruses. To counteract viral antagonism, MORC3 represses a noncanonical pathway of type-I-interferon (IFN) such that viral inhibition of MORC3 triggers ( > 10,000-fold) IFN induction. H...
Somatic cells compartmentalise their carbohydrate metabolism to sustain germ cell survival [0.03%]
体细胞通过隔室化碳水化合物代谢来维持生殖细胞的生存
Diego Sainz de la Maza,Holly Jefferson,Celine I Brucker et al.
Diego Sainz de la Maza et al.
To ensure success in reproduction, organisms dedicate substantial resources to supporting the germline. In testes, somatic gonadal cells form a barrier that isolates germ cells from circulating nutrients, raising the question of how germ ce...
Alternative splicing broadens antiviral diversity at the human OAS2 locus [0.03%]
人源OAS2基因座的可变剪切抗病毒多样性研究
Emma L Davies,Alegna Calderon Nuñez,Allison L Ward et al.
Emma L Davies et al.
Interferons (IFN) are cytokines that regulate the expression of hundreds of genes during viral infections to generate a broadly antiviral environment in the stimulated cell. Antiviral breadth is provided by the concurrent expression of many...
Apolipoprotein D neofunctionalization couples lipid allocation to wing evolution [0.03%]
载脂蛋白D的新功能化连接了脂质分配与翅膀的进化
Yuxin Huang,Yinghui Li,Shunze Jia et al.
Yuxin Huang et al.
The origin of insect wings marked a pivotal evolutionary innovation that enabled their extraordinary ecological success, yet the metabolic mechanisms sustaining this transition remain elusive. Here, we identify apolipoprotein D2 (ApoD2)-a n...
Molecular architecture of OXGR1 reveals an evolutionary conserved mechanisms for metabolite surveillance [0.03%]
OXGR1的分子结构揭示了代谢监测的进化保守机制
Xinyue Zhang,Yujie Lu,Xinheng He et al.
Xinyue Zhang et al.
The ability of cells to sense and respond to metabolic signals is fundamental to life, yet the molecular mechanisms underlying metabolite surveillance remain incompletely understood. Here, we elucidate the structural basis of metabolite rec...