Vanessa Nunes,Margarida Moura,Sara F Silva et al.
Vanessa Nunes et al.
Accurate transition into mitosis driven by cyclin B1-CDK1 activity is essential to avoid chromosome segregation errors and preserve genome integrity. How this activity is spatially controlled to trigger mitotic onset remains unclear. Here, ...
NDR kinase SAX-1 controls dendrite branch-specific elimination during neuronal remodeling in C. elegans [0.03%]
线虫中NDR激酶SAX-1控制神经元重塑过程中树突分支特异性的消除作用
Paola V Figueroa-Delgado,Shaul Yogev
Paola V Figueroa-Delgado
Neuronal remodeling is crucial for proper nervous system development and function. Despite significant advances, the underlying mechanisms that govern this process remain poorly understood. Here, we adapted C. elegans IL2 sensory neurons as...
Jiuya He,Joe Carroll,Shujing Ding et al.
Jiuya He et al.
Human ATP synthase is a molecular rotary machine bound in inner mitochondrial membranes, built from twenty-eight subunits of seventeen kinds, two encoded in mitochondrial DNA, the remainder in nuclear genes. The machine consists of a rotor ...
Substrate-induced assembly and functional mechanism of the membrane protein insertase SecYEG-YidC [0.03%]
底物诱导的SecYEG-YidC插入酶膜蛋白复合体组装及作用机制
Max Busch,Cristian Rosales-Hernandez,Michael Kamel et al.
Max Busch et al.
The Sec translocon and the YidC/Oxa1-type insertases universally mediate biogenesis of α-helical membrane proteins, but the molecular basis of their cooperation has remained disputed. Recent discovery of multi-subunit insertases assembled ...
Conformational changes of the baseplate regulating tail contraction of Staphylococcus phage 812 [0.03%]
葡萄球菌噬菌体812通过底板构象变化调节尾部收缩
Ján Bíňovský,Marta Šiborová,Maryna Zlatohurska et al.
Ján Bíňovský et al.
Phages with contractile tails employ elaborate mechanisms to penetrate bacterial cell walls and deliver their genomes into the host cytoplasm. Here, we used cryo-EM to show that the baseplate of phage 812, a member of the Kayvirus genus, wh...
Cellular assembly and functional resilience of the mammalian RNA exosome [0.03%]
哺乳动物RNA外切酶的细胞装配及其功能耐受性
Tsimafei Navalayeu,Nikolaus Beer,Monika Bebjaková et al.
Tsimafei Navalayeu et al.
Most eukaryotic proteins assemble into multisubunit complexes that coordinate essential cellular functions, yet the principles governing their assembly and proteostatic control remain largely undefined. Here, we systematically dissect the c...
OMA1 protects from liver injury and tumorigenesis during aging by controlling hepatic immunogenicity [0.03%]
OMA1通过控制肝免疫原性来保护肝脏免受衰老引起的损伤和肿瘤发生
Yolanda Martí-Mateos,María Del Mar Muñoz-Hernández,Manuel M Gómez de Las Heras et al.
Yolanda Martí-Mateos et al.
Hepatic inflammation and immunosurveillance play major roles in the progression of liver cancer. A common trigger for hepatic inflammation is oxidative stress, which stems from mitochondrial dysfunction. Here, we demonstrate that deletion o...
mRAVE governs lysosomal catabolism through basal and mTORC1-regulated V-ATPase assembly [0.03%]
mRAVE通过基础和mTORC1调节的V-ATP酶组装调控溶酶体降解作用
Nora S Siefert,Andrea Zanotti,Anastasija Paneva et al.
Nora S Siefert et al.
Acidification of lysosomes, endosomes and the Golgi underpins organelle-specific functions within the endomembrane system. This process is driven by vacuolar-type H + -ATPases (V-ATPases), proton pumps that reversibly assemble from peripher...
The identity crisis of cryptic lncRNAs: when non-coding RNAs translate into small peptides [0.03%]
神秘的长非编码RNA的身份危机：当非编码RNA翻译出小肽时
Leoš Shivaya Valášek,Filip Brázdovič,Filip Trčka et al.
Leoš Shivaya Valášek et al.
From a historical perspective, long non-coding RNAs (lncRNAs) represent a relatively short story. However, this story has many plot lines, thrills, twists, and turns that altogether form quite a long saga of its own. lncRNAs stay at the for...
The oocyte-enriched metabolite serotonin alleviates cellular senescence and aging phenotypes in the mouse [0.03%]
小鼠卵母细胞富集的代谢产物5-羟色胺可缓解体细胞衰老及相关衰老表型
Yuyan Xu,Ling Zhang,Xufeng Liao et al.
Yuyan Xu et al.
Whether metabolites enriched at early developmental stages affect cellular and organismal aging remains unclear. In this study, we comprehensively profiled the metabolic landscape of mouse oocytes in comparison to cleavage-stage embryos. Ou...