Inhibition of lagging strand replication by G-rich telomeric DNA and the shelterin subunit POT1 [0.03%]
富含G的端粒DNA和 Shelterin亚基POT1对滞后链复制的抑制作用
Ciara Leonard-Booker,Giulia Mazzucco,Charlotte E L Fisher et al.
Ciara Leonard-Booker et al.
Telomeres preserve stable eukaryotic chromosomes by protecting the natural chromosome ends from DNA repair but pose a persistent challenge to the replication machinery and an endogenous source of replication stress. Different features have ...
Local autophagy impairment triggers brain-wide presynaptic remodeling and resilience [0.03%]
局部自噬损伤触发全脑突触前重塑和恢复力
David Toppe,Sheng Huang,Janine Lützkendorf et al.
David Toppe et al.
Neural circuits must remain functionally stable while adapting to changing demands and levels of stress. While this balance is thought to rely on plasticity programs integrating molecular and activity-dependent signals, mechanistic models o...
Structure and receptor recognition of type-II feline infectious peritonitis virus spike glycoprotein [0.03%]
II型猫传染性腹膜炎病毒刺突糖蛋白的结构与受体识别
Sheng Niu,Yuyang Tian,Linh Nguyen et al.
Sheng Niu et al.
Type-II feline infectious peritonitis virus (FIPV-II) is a lethal alphacoronavirus, whose high homology with the human coronavirus CCoV-HuPn-2018 carries the risk of potential zoonotic FIPV-II transmission to humans. FIPV-II infects felids ...
Aashika Sekar,Alberto Rizzo,Elodie Sins et al.
Aashika Sekar et al.
Hippo signalling is an evolutionarily conserved pathway that regulates tissue growth. The FERM domain protein Expanded (Ex) integrates polarity cues to activate the Hippo pathway. Previous work has shown that the apicobasal polarity protein...
The TPR2 corepressor forms condensates with repressors to fine-tune growth and development in rice [0.03%]
TPR2核心抑制物与抑制物凝聚调节水稻生长和发育精细调控机制
Yu Zhang,Bingchen Li,Yu Chen et al.
Yu Zhang et al.
Transcriptional repression is a central mechanism regulating plant growth and development, yet how plant-specific corepressors achieve robust gene silencing remains unclear. Here, we identify the rice corepressor TPR2 (TOPLESS-RELATED 2) as...
SenFlag gene signature identifies senescent cells in mouse and human tissues through a conserved core transcriptional program [0.03%]
SenFlag基因特征标志通过保守的核心转录程序识别小鼠和人类组织中的衰老细胞
Abdullah Altulea,Sebastian Mackedenski,Jamil Nehme et al.
Abdullah Altulea et al.
Identifying senescent cells via single-cell transcriptome profiling data remains challenging due to cellular heterogeneity and overlap with other cellular states. Here, we present SenFlag, a streamlined gene signature for enhanced identific...
Scalable phosphotyrosine enrichment with SH2 superbinder enables deep profiling of EGF responses [0.03%]
利用SH2超结合蛋白富集磷酸酪氨酸，实现EGF响应的深度谱型分析
Alexis T Chang,Ricard A Rodriguez-Mias,Matthew D Berg et al.
Alexis T Chang et al.
Phosphotyrosine signaling plays a critical role in many biological processes, from cell proliferation to immune response. Despite its importance, proteomic studies of tyrosine phosphorylation have been limited in scale and throughput due to...
Essential nucleus-apical pole linkage maintains division fidelity during Plasmodium progeny formation [0.03%]
维持裂殖体形成过程中子代生成准确性的核心核-顶点结合骨架元件
Buyuan He,Ilzat Ali,Lilian P Dorner et al.
Buyuan He et al.
Plasmodium parasites, the causative agents of malaria, undergo complex replication within vertebrate and insect hosts, presenting unique opportunities for therapeutic intervention. A key challenge during these replication events, i.e., schi...
Mitochondrial calcium regulates lipid metabolism by modulating tethering of mitochondria to lipid droplets [0.03%]
线粒体钙通过调节线粒体与脂滴的连接来调控脂质代谢
Rebeca Acin-Perez,Essam A Assali,Michaela Veliova et al.
Rebeca Acin-Perez et al.
Adrenergic stimulation of brown adipocytes induces a robust detachment of mitochondria from lipid droplets (LD), which is followed by lipolysis and lipid catabolism. However, the signals inducing mitochondria attachment or detachment, and t...