Author Correction: A chromatin-remodeling-independent role for ATRX in protecting centromeric cohesion [0.03%]
作者更正：ATRX的非染色质重塑独立作用于保护着丝粒凝聚
Lei Zhao,Xueying Yuan,Qinfu Chen et al.
Lei Zhao et al.
Published Erratum
The EMBO journal. 2026 Jul 16. DOI:10.1038/s44318-026-00866-1 2026
Author Correction: Asymmetric sheath coordination controls flagellar architecture and function in Leptospira spirochete [0.03%]
作者更正：不对称鞘配位控制螺旋体Spirochetes鞭毛结构和功能
Akihiro Kawamoto,Toshiki Kuribayashi,Masatomo Morita et al.
Akihiro Kawamoto et al.
Published Erratum
The EMBO journal. 2026 Jul 16. DOI:10.1038/s44318-026-00859-0 2026
Developmental priming of adult proteostasis and longevity by NuA4 complex activity in early life [0.03%]
生命早期NuA4复合体活性对成年蛋白稳态和寿命的发育启动作用
Yihan Wang,Xiong Xiong,Runshuai Zhang et al.
Yihan Wang et al.
Proteostasis collapse, a hallmark of aging and neurodegeneration like Alzheimer's disease (AD), causes irreversible damage in late life. Whether late-life proteostasis capacity is developmentally programmed remains unclear, as mechanistic s...
Ana Ramírez-Sánchez,Miguel Jociles-Ortega,José Manuel García-Martínez et al.
Ana Ramírez-Sánchez et al.
The impact of the metabolic microenvironment on epigenetically plastic cancer cells underpins phenotypic heterogeneity, a major cause of metastasis and therapy resistance. Nutrient limitation is a key microenvironmental stress, and can caus...
A conserved basic motif mediates membrane anchoring and TRAF2 recruitment across costimulatory TNFRs [0.03%]
保守的基本基序介导共刺激性TNFRs跨膜锚定和TRAF2招募
Jiali Zhu,Xi Xu,Pei Liu et al.
Jiali Zhu et al.
Costimulatory receptors of the TNFR superfamily are key components in synthetic immunoreceptors, yet how their intracellular domains coordinate membrane anchoring with adaptor recruitment remains unresolved. Here, using solution-state NMR a...
Spalt-related is an inhibitor of mTORC1-mediated growth activated by the integrated stress response [0.03%]
Spalt相关的是一种由整合应激反应激活的mTORC1介导的生长抑制剂
Onur Deniz,Ying Liu,Tuuli Kirkinen et al.
Onur Deniz et al.
Anabolic and catabolic processes are coordinated by a conserved regulatory network, which includes the nutrient-sensing protein kinase mTOR complex 1 (mTORC1) and the insulin- and stress-responsive transcription factor FoxO. In a physiologi...
CDK8 remodels the tumor microenvironment and promotes resistance to KRASG12D inhibitors and daraxonrasib in PDAC [0.03%]
CDK8重塑肿瘤微环境并促进PDAC中KRASG12D抑制剂和达拉索那替尼的耐药性
Kathleen M McAndrews,Krishnan K Mahadevan,Bingrui Li et al.
Kathleen M McAndrews et al.
Mutations in KRAS are a dominant driver of pancreatic ductal adenocarcinoma (PDAC), with about 50% of patients presenting with KRASG12D mutations. Small molecule inhibitors targeting KRASG12D suppress PDAC; however, the contribution of the ...
Oncogenic EGFR rewires STING-TBK1 signalosomes to license DNA damage tolerance in NSCLC [0.03%]
致癌表皮生长因子受体重新布线STING-TBK1信号复合物以在非小细胞肺癌中授权DNA损伤容许性
Qin Shen,Chen Mei,Yidan Chen et al.
Qin Shen et al.
EGFR hotspot mutations (mEGFR), including primary L858R, exon 19 deletion, and secondary T790M, are pivotal oncogenic drivers in human non-small cell lung cancer (NSCLC). At the same time, NSCLC resistance to third-generation tyrosine kinas...
Mechanical constraints regulate embryonic stem cell mitosis in the developing brain [0.03%]
机械限制调节发育中大脑的胚胎干细胞有丝分裂
Véronique Marthiens,Lin Jawish,Margaux Malosse et al.
Véronique Marthiens et al.
Research on mitosis has predominantly examined cell-autonomous mechanisms, yet its regulation and consequences within the broader physiological context remain largely unexplored. It remains, therefore, unknown whether and how spindle assemb...
Alterations in chromatin organization promote totipotent-like features in a DPPA2/DUX-dependent manner [0.03%]
染色质重塑以DPPA2/DUX依赖方式促进类全能干细胞特性产生
Grace I Carey,Maria Vega-Sendino,Desiree Tillo et al.
Grace I Carey et al.
2-cell like cells (2CLC) are a transiently cycling population of cells with totipotent-associated features. Although CTCF depletion induces 2CLC conversion in mouse ESC, whether this reprogramming is a consequence of disrupted higher-order ...