Tripartite ER-mitochondria-lipid droplets contact sites control adipocyte metabolic flexibility [0.03%]
三方内质网-线粒体-脂滴接触位点控制脂肪细胞代谢灵活性
Marie Palard,Gilliane Chadeuf,Maxime Carpentier et al.
Marie Palard et al.
Adipocyte dysfunction is a major driver of obesity-associated cardiometabolic disease, underscoring the need to understand how lipid storage and mobilization are regulated and disrupted. The ER-anchored protein Seipin governs lipid droplet ...
Proteolytic activation of executioner caspase-3 and -7 regulates different physiological processes in mice [0.03%]
在小鼠中蛋白酶激活执行者半胱氨酸凋亡酶-3和-7调控不同的生理过程
Noëlle Sieg,Johanna Stachelscheid,Besarta Thaqi et al.
Noëlle Sieg et al.
Caspase-3 (CASP3) and caspase-7 (CASP7) are the two major executioner caspases that are proteolytically activated by upstream initiator caspases. They possess almost indistinguishable activity, which has led to the overall view that these c...
Author Correction: Multifunctional roles of Brl1-Brr6 in nuclear envelope fusion during nuclear pore complex biogenesis [0.03%]
作者更正：芽殖酵母核孔复合体生物发生过程中核膜融合事件中Brl1-Brr6的多功能作用
Sayan Mondal,Annett Neuner,Azqa Ajmal Khan et al.
Sayan Mondal et al.
Published Erratum
The EMBO journal. 2026 Jul 20. DOI:10.1038/s44318-026-00865-2 2026
Atg23 prevents aberrant fusion of Atg9 vesicles during delivery to autophagosome formation sites [0.03%]
ATG23防止ATG9囊泡在向自噬体形成部位运输过程中异常融合
Takumi Kimura,Takayuki Shima,Tetsuya Kotani et al.
Takumi Kimura et al.
Autophagosome biogenesis depends on the accurate delivery of membrane lipids to the pre-autophagosomal structure. Golgi/endosome-derived Atg9 vesicles provide the membrane seed for this process, but how they are trafficked through the cytop...
Vps1 drives membrane constriction and fission necessary for endosomal protein sorting [0.03%]
Vps1驱动的膜收缩和分裂可促进内体蛋白分选
Shilpa Gopan,Uma Swaminathan,Gurmail Singh et al.
Shilpa Gopan et al.
The trafficking of cargo between endosomes and the Golgi apparatus uses both retromer-dependent and retromer-independent routes. Disruptions to these routes lead to the mis-sorting of lysosomal cargo, and associated metabolic and neurologic...
Reactive oxygen species stimulate Paneth cell plasticity and diminish antimicrobial function [0.03%]
活性氧促进潘氏细胞的重塑并降低其抗菌功能
Jiaxing Yang,Sheila Bandyopadhyay,Dahui Wang et al.
Jiaxing Yang et al.
The gut epithelium faces constant environmental oxidative stresses. How it responds to pathological reactive oxygen species (ROS) is not fully understood. Using Paneth cell (PC) lineage reporters and genetic tracing, we show that as PC prog...
Author Correction: Distinct heterochromatin-like domains promote transcriptional memory and silence parasitic genetic elements in bacteria [0.03%]
作者更正：不同的异染色质样域促进细菌的转录记忆并使寄生遗传元件失活
Haley Minami Amemiya,Thomas J Goss,Taylor M Nye et al.
Haley Minami Amemiya et al.
Published Erratum
The EMBO journal. 2026 Jul 17. DOI:10.1038/s44318-026-00860-7 2026
Author Correction: Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cells [0.03%]
作者更正：功能性筛选揭示miR-27a/24在胚胎干细胞分化中的重要作用
Yanni Ma,Nan Yao,Guang Liu et al.
Yanni Ma et al.
Published Erratum
The EMBO journal. 2026 Jul 17. DOI:10.1038/s44318-026-00863-4 2026
Author Correction: Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells [0.03%]
作者更正：癌症细胞中获得性的保守残基突变导致对CDK7抑制剂的耐药性
Chun-Fui Lai,Victoria I Cushing,Ellen Olden et al.
Chun-Fui Lai et al.
Published Erratum
The EMBO journal. 2026 Jul 17. DOI:10.1038/s44318-026-00862-5 2026
Author Correction: Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors [0.03%]
作者更正：NR3亚型谷氨酸受体识别配体的分子机制
Yongneng Yao,Chris B Harrison,Lydia Freddolino et al.
Yongneng Yao et al.
Published Erratum
The EMBO journal. 2026 Jul 16. DOI:10.1038/s44318-026-00861-6 2026