Damage recognition by intestinal stem cells via Draper promotes adult Drosophila midgut regeneration [0.03%]
肠干细胞通过Draper识别损伤并促进成年果蝇中肠再生
Martina Legido,Marie Srotyr,Rebecca Wafer et al.
Martina Legido et al.
Tissue regeneration after injury is crucial for restoring epithelial structure and function. Upon damage, a regenerative microenvironment forms that provides signalling cues that stimulate stem cell proliferation to replace lost cells. Whil...
Author Correction: From cell atlases to mechanisms: bridging scRNA-seq discovery with in vivo genetics [0.03%]
作者更正：从细胞图谱到机制：桥联单细胞基因表达与体内遗传学
Bin Zhou
Bin Zhou
Published Erratum
The EMBO journal. 2026 Aug 4. DOI:10.1038/s44318-026-00872-3 2026
Membrane lipid composition and rapid endocytic retrieval modulate Wingless secretion [0.03%]
翼蛋白分泌受细胞膜脂质组成和快速内吞作用的调节
Ines Alvarez-Rodrigo,David Willnow,Cyrille Alexandre et al.
Ines Alvarez-Rodrigo et al.
The Wnt family ligands carry a lipid moiety that must be shielded from the aqueous environment. During secretion, this is achieved by the cargo receptor Wntless. The effect of acute endocytosis inhibition suggests that Wingless dissociates ...
Timescale mismatch: redefining ecological opportunity for evolution in the Anthropocene [0.03%]
时空不匹配：在人类世时期从新定义生态机会以应对进化问题
Christian R Voolstra,Ruben J Hermann,Herwig Stibor et al.
Christian R Voolstra et al.
NF-κB/RelA signaling required for CD40-induced humoral immunity depends on specific NEMO lysine residues in mice [0.03%]
小鼠CD40诱导的体液免疫依赖于特定的NEMO赖氨酸残基 NF-κB/RelA信号通路的作用
Donna Li,Shelly M Wuerzberger-Davis,Yuhong Chen et al.
Donna Li et al.
Oxidative stress and genotoxic damage activate NF-κB signaling through intracellular pathways distinct from those initiated by membrane receptors. DNA damage selectively induces post-translational modifications at lysine residues 277 and 3...
Polo/PLK1 phosphorylation relieves Centrosomin/Cnn autoinhibition to promote centrosome scaffold assembly [0.03%]
polo / plk1 磷酸化解除中心体蛋白Centrosomin的自抑制以促进中心体支架装配
Nada Mohamad,Siu-Shing Wong,Anupa Majumdar et al.
Nada Mohamad et al.
Mitotic centrosome maturation requires Polo/PLK1-dependent expansion of the pericentriolar material (PCM). In Drosophila, Centrosomin (Cnn) assembles a scaffold around mitotic centrioles through interactions between its PReM and CM2 domains...
The Arabidopsis SPFH protein HIR2 modulates receptor signaling and plasma membrane organization [0.03%]
SPFH蛋白HIR2通过调节受体信号转导和质膜组织来调控拟南芥生长素反应
Hannah Weber,Alexandra Ehinger,Dagmar Kolb et al.
Hannah Weber et al.
Plant plasma membrane proteins are organized into distinct domains; however, the principles that govern this spatial organization are not fully understood. HYPERSENSITIVE-INDUCED REACTION (HIR) proteins are plant-specific members of the sto...
Revisiting nerve nets: functional organization and evolutionary implications [0.03%]
再论神经网：功能组织和进化含义
Kei Jokura,Gáspár Jékely
Kei Jokura
Nerve nets-characterised by scattered neurons and mesh-like projections-represent a widespread organisation of nervous tissue. Nerve nets have uniquely diffuse conductivity and an apparent simplicity that features in many theories on the ev...
RAD54L coordinates the nucleolar DNA damage response to maintain rDNA stability [0.03%]
RAD54L通过协调核仁中的DNA损伤反应来维持rDNA稳定性
Ruofei Liu,Jiachen Xuan,Carmelo Cerra et al.
Ruofei Liu et al.
The nucleolus is organized around actively transcribed ribosomal RNA genes (rDNA), where high RNA polymerase I (Pol I) activity creates intrinsic susceptibility to replication stress and DNA damage. Here, we identify the DNA translocase RAD...
FUS controls muscle differentiation through phase separation-mediated recruitment of the transcription factors MEF2 and ETV5 [0.03%]
液-液相分离介导的转录因子MEF2和ETV5的招募调控FUS对肌细胞分化的功能
Gina Picchiarelli,Anne Wienand,Salim Megat et al.
Gina Picchiarelli et al.
FUS is an RNA-binding protein mutated in amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by progressive muscle weakness. We show in this work that a heterozygous knock-in mutation in the mouse Fus gene leads t...